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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry (Easton), 2000-08, Vol.39 (30), p.8698-8704

2000

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Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Current pharmaceutical design, 2005-01, Vol.11 (26), p.3363

2005

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Gamma-secretase inhibition

Biochemical Society transactions, 2002-08, Vol.30 (4), p.534

2002

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease

The Journal of biological chemistry, 2001-09, Vol.276 (36), p.33923-33929

2001

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

Expert opinion on investigational drugs, 2005-11, Vol.14 (11), p.1385-1409

2005

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γ-Secretase Complex Assembly within the Early Secretory Pathway

The Journal of biological chemistry, 2005-02, Vol.280 (8), p.6471-6478

2005

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4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.280-284

2006

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Cyclic sulfamide γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4212-4216

2005

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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2275-2278

2003

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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Biochemistry (Easton), 2003-07, Vol.42 (27), p.8133-8142

2003

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.45394-45402

2001

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The Intramembrane Cleavage Site of the Amyloid Precursor Protein Depends on the Length of Its Transmembrane Domain

Proceedings of the National Academy of Sciences - PNAS, 2002-02, Vol.99 (3), p.1365-1370

2002

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Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (∗)

The Journal of biological chemistry, 1996-01, Vol.271 (3), p.1613-1620

1996

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Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Journal of lipid research, 2004-12, Vol.45 (12), p.2368-2376

2004

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Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12523-12535

2005

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A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.373-378

2005

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gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13077-13085

2003

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Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

Neurobiology of aging, 2004-10, Vol.25 (9), p.1175-1185

2004

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425 Alternative splicing of exon 15 regulates APP conformation

Neurobiology of aging, 1996, Vol.17 (4), p.S106-S106

1996

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gamma-Secretase as a target for drug intervention in Alzheimer's disease

Current opinion in drug discovery & development, 2004-09, Vol.7 (5), p.709

2004

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426 APP shares glycan modifications characteristic of cell adhesion molecules

Neurobiology of aging, 1996, Vol.17 (4), p.S106-S106

1996

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619 Reduction of copper(II) to copper(I) by the Amyloid Precursor Protein (APP) of Alzheimer's disease

Neurobiology of aging, 1996, Vol.17 (4), p.S154-S154

1996

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Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model

Antimicrobial Agents and Chemotherapy, 1986-07, Vol.30 (1), p.105-109

1986

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Polarized Expression of G Protein-coupled Receptors and an All-or-None Discharge of Ca2+ Pools at Initiation Sites of [Ca2+]i Waves in Polarized Exocrine Cells

The Journal of biological chemistry, 2001-11, Vol.276 (47), p.44146-44156

2001

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Gamma-secretase inhibition

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

γ-Secretase Complex Assembly within the Early Secretory Pathway

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Cyclic sulfamide γ-secretase inhibitors

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Intramembrane Cleavage Site of the Amyloid Precursor Protein Depends on the Length of Its Transmembrane Domain

Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (∗)

Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

425 Alternative splicing of exon 15 regulates APP conformation

gamma-Secretase as a target for drug intervention in Alzheimer's disease

426 APP shares glycan modifications characteristic of cell adhesion molecules

619 Reduction of copper(II) to copper(I) by the Amyloid Precursor Protein (APP) of Alzheimer's disease

Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model

Polarized Expression of G Protein-coupled Receptors and an All-or-None Discharge of Ca2+ Pools at Initiation Sites of [Ca2+]i Waves in Polarized Exocrine Cells

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