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Opioid receptors: single molecule studies shed light on mechanisms of efficacy

Signal transduction and targeted therapy, 2024-08, Vol.9 (1), p.219-2, Article 219

2024

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Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction

Circulation research, 2024-05, Vol.134 (10), p.1259-1275

2024

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DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

Scientific reports, 2024-04, Vol.14 (1), p.8178-10, Article 8178

2024

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Differential interaction patterns of opioid analgesics with [micro] opioid receptors correlate with ligand-specific voltage sensitivity

eLife, 2023-11, Vol.12

2023

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Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

eLife, 2023-11, Vol.12

2023

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EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins

Molecular pharmacology, 2023-09, Vol.104 (3), p.80-91

2023

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Interaction kinetics between p115-RhoGEF and Gα 13 are determined by unique molecular interactions affecting agonist sensitivity

Communications biology, 2022-11, Vol.5 (1), p.1287

2022

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Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

Communications biology, 2022-11, Vol.5 (1), p.1287-1287, Article 1287

2022

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Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells

Pharmacology research & perspectives, 2022-10, Vol.10 (5), p.e01013-n/a

2022

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Residency time of agonists does not affect the stability of GPCR–arrestin complexes

British journal of pharmacology, 2022-08, Vol.179 (16), p.4107-4116

2022

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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

Nature communications, 2022-05, Vol.13 (1), p.2567-2567, Article 2567

2022

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Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021-12, Vol.10

2021

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Disentangling bias between G q , GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine receptor

eLife, 2021-12, Vol.10

2021

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Structures in G proteins important for subtype selective receptor binding and subsequent activation

Communications biology, 2021-05, Vol.4 (1), p.635-635, Article 635

2021

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Pharmacological Characterization of the Stick Insect Carausius morosus Allatostatin‑C Receptor with Its Endogenous Agonist

ACS omega, 2020-12, Vol.5 (50), p.32183-32194

2020

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The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Frontiers in pharmacology, 2020-08, Vol.11, p.1271-1271

2020

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Voltage modulates the effect of μ‐receptor activation in a ligand‐dependent manner

British journal of pharmacology, 2020-08, Vol.177 (15), p.3489-3504

2020

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Orphan G Protein–Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

Circulation (New York, N.Y.), 2020-04, Vol.141 (14), p.1168-1183

2020

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Voltage Dependence of Prostanoid Receptors

Molecular pharmacology, 2020-04, Vol.97 (4), p.267-277

2020

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The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors

Biochemical and biophysical research communications, 2019-12, Vol.520 (2), p.327-332

2019

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Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Molecular pharmacology, 2019-12, Vol.96 (6), p.851-861

2019

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Direct targeting of Gα q and Gα 11 oncoproteins in cancer cells

Science signaling, 2019-03, Vol.12 (573)

2019

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Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Science signaling, 2018-07, Vol.11 (539)

2018

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Lifetime of muscarinic receptor–G-protein complexes determines coupling efficiency and G-protein subtype selectivity

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (19), p.5016-5021

2018

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Related GPCRs couple differently to Gs: preassociation between G protein and 5‐HT7 serotonin receptor reveals movement of Gαs upon receptor activation

The FASEB journal, 2018-02, Vol.32 (2), p.1059-1069

2018

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Opioid receptors: single molecule studies shed light on mechanisms of efficacy

Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction

DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

Differential interaction patterns of opioid analgesics with [micro] opioid receptors correlate with ligand-specific voltage sensitivity

Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins

Interaction kinetics between p115-RhoGEF and Gα 13 are determined by unique molecular interactions affecting agonist sensitivity

Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells

Residency time of agonists does not affect the stability of GPCR–arrestin complexes

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

Disentangling bias between G q , GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine receptor

Structures in G proteins important for subtype selective receptor binding and subsequent activation

Pharmacological Characterization of the Stick Insect Carausius morosus Allatostatin‑C Receptor with Its Endogenous Agonist

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Voltage modulates the effect of μ‐receptor activation in a ligand‐dependent manner

Orphan G Protein–Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

Voltage Dependence of Prostanoid Receptors

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors

Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Direct targeting of Gα q and Gα 11 oncoproteins in cancer cells

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Lifetime of muscarinic receptor–G-protein complexes determines coupling efficiency and G-protein subtype selectivity

Related GPCRs couple differently to Gs: preassociation between G protein and 5‐HT7 serotonin receptor reveals movement of Gαs upon receptor activation

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