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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

Nature communications, 2022-05, Vol.13 (1), p.2567-2567, Article 2567

2022

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DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

Scientific reports, 2024-04, Vol.14 (1), p.8178-8178

2024

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Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021-12, Vol.10

2021

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The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Frontiers in pharmacology, 2020-08, Vol.11, p.1271-1271

2020

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Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Molecular pharmacology, 2019-12, Vol.96 (6), p.851-861

2019

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Structures in G proteins important for subtype selective receptor binding and subsequent activation

Communications biology, 2021-05, Vol.4 (1), p.635-635, Article 635

2021

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Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β1-Adrenergic but Locally Confined β2-Adrenergic Receptor–Mediated Signaling

Circulation research, 2006-11, Vol.99 (10), p.1084-1091

2006

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Gi Protein Activation in Intact Cells Involves Subunit Rearrangement Rather than Dissociation

Proceedings of the National Academy of Sciences - PNAS, 2003-12, Vol.100 (26), p.16077-16082

2003

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Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

Communications biology, 2022-11, Vol.5 (1), p.1287-1287, Article 1287

2022

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Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

eLife, 2023-11, Vol.12

2023

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Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

Molecular endocrinology (Baltimore, Md.), 2009-05, Vol.23 (5), p.590-599

2009

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A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells

Nature methods, 2005-03, Vol.2 (3), p.171-176

2005

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Dynamics of receptor/G protein coupling in living cells

The EMBO journal, 2005-12, Vol.24 (23), p.4106-4114

2005

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Real-time optical recording of β1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

The Journal of clinical investigation, 2007-01, Vol.117 (1), p.229-235

2007

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Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia‐associated RhoGEF

The FASEB journal, 2017-08, Vol.31 (8), p.3663-3676

2017

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Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein Heterotrimer

The Journal of biological chemistry, 2006-08, Vol.281 (34), p.24506-24511

2006

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Adenylyl cyclases 5 and 6 underlie PIP3‐dependent regulation

The FASEB journal, 2015-08, Vol.29 (8), p.3458-3471

2015

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Analysis of receptor oligomerization by FRAP microscopy

Nature methods, 2009-03, Vol.6 (3), p.225-230

2009

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Functional Regulation of L-type Calcium Channels via Protein Kinase A-mediated Phosphorylation of the β2 Subunit

The Journal of biological chemistry, , Vol.274 (48), p.33851-33854

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Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure

PloS one, 2007-03, Vol.2 (3), p.e292-e292

2007

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The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively

PloS one, 2014-09, Vol.9 (9), p.e106890

2014

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The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors

Biochemical and biophysical research communications, 2019-12, Vol.520 (2), p.327-332

2019

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Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

Biochemical journal, 2001-04, Vol.355 (Pt 1), p.189-197

2001

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Activation and Deactivation Kinetics of α2A- and α2C-Adrenergic Receptor-activated G Protein-activated Inwardly Rectifying K+ Channel Currents

The Journal of biological chemistry, 2001-12, Vol.276 (50), p.47512-47517

2001

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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Structures in G proteins important for subtype selective receptor binding and subsequent activation

Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β1-Adrenergic but Locally Confined β2-Adrenergic Receptor–Mediated Signaling

Gi Protein Activation in Intact Cells Involves Subunit Rearrangement Rather than Dissociation

Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells

Dynamics of receptor/G protein coupling in living cells

Real-time optical recording of β1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia‐associated RhoGEF

Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein Heterotrimer

Adenylyl cyclases 5 and 6 underlie PIP3‐dependent regulation

Analysis of receptor oligomerization by FRAP microscopy

Functional Regulation of L-type Calcium Channels via Protein Kinase A-mediated Phosphorylation of the β2 Subunit

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure

The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

Activation and Deactivation Kinetics of α2A- and α2C-Adrenergic Receptor-activated G Protein-activated Inwardly Rectifying K+ Channel Currents

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