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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

Nature communications, 2022-05, Vol.13 (1), p.2567-2567, Article 2567

2022

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DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

Scientific reports, 2024-04, Vol.14 (1), p.8178-8178

2024

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Voltage regulates adrenergic receptor function

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1536-1541

2013

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Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021-12, Vol.10

2021

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The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Frontiers in pharmacology, 2020-08, Vol.11, p.1271-1271

2020

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Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Molecular pharmacology, 2019-12, Vol.96 (6), p.851-861

2019

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Orphan G Protein–Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

Circulation (New York, N.Y.), 2020-04, Vol.141 (14), p.1168-1183

2020

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Structures in G proteins important for subtype selective receptor binding and subsequent activation

Communications biology, 2021-05, Vol.4 (1), p.635-635, Article 635

2021

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Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β1-Adrenergic but Locally Confined β2-Adrenergic Receptor–Mediated Signaling

Circulation research, 2006-11, Vol.99 (10), p.1084-1091

2006

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Gi Protein Activation in Intact Cells Involves Subunit Rearrangement Rather than Dissociation

Proceedings of the National Academy of Sciences - PNAS, 2003-12, Vol.100 (26), p.16077-16082

2003

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Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

Communications biology, 2022-11, Vol.5 (1), p.1287-1287, Article 1287

2022

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Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

eLife, 2023-11, Vol.12

2023

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Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

Molecular endocrinology (Baltimore, Md.), 2009-05, Vol.23 (5), p.590-599

2009

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Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors

Trends in pharmacological sciences (Regular ed.), 2008-03, Vol.29 (3), p.159-165

2008

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A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

The Journal of cell biology, 2017-01, Vol.216 (1), p.199-215

2017

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Real-time optical recording of β1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

The Journal of clinical investigation, 2007-01, Vol.117 (1), p.229-235

2007

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Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia‐associated RhoGEF

The FASEB journal, 2017-08, Vol.31 (8), p.3663-3676

2017

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GS Activation Is Time-limiting in Initiating Receptor-mediated Signaling

The Journal of biological chemistry, 2006-11, Vol.281 (44), p.33345-33351

2006

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Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells

Pharmacology research & perspectives, 2022-10, Vol.10 (5), p.e01013-n/a

2022

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Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein Heterotrimer

The Journal of biological chemistry, 2006-08, Vol.281 (34), p.24506-24511

2006

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Functional Regulation of L-type Calcium Channels via Protein Kinase A-mediated Phosphorylation of the β2 Subunit

The Journal of biological chemistry, , Vol.274 (48), p.33851-33854

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Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure

PloS one, 2007-03, Vol.2 (3), p.e292-e292

2007

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The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively

PloS one, 2014-09, Vol.9 (9), p.e106890

2014

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Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

Nature biotechnology, 2003-07, Vol.21 (7), p.807-812

2003

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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites

DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time

Voltage regulates adrenergic receptor function

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Orphan G Protein–Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

Structures in G proteins important for subtype selective receptor binding and subsequent activation

Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β1-Adrenergic but Locally Confined β2-Adrenergic Receptor–Mediated Signaling

Gi Protein Activation in Intact Cells Involves Subunit Rearrangement Rather than Dissociation

Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib

Real-time optical recording of β1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia‐associated RhoGEF

GS Activation Is Time-limiting in Initiating Receptor-mediated Signaling

Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells

Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein Heterotrimer

Functional Regulation of L-type Calcium Channels via Protein Kinase A-mediated Phosphorylation of the β2 Subunit

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure

The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

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