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MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic

Frontiers in immunology, 2017-12, Vol.8, p.1803-1803

2017

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Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

Nature communications, 2017-07, Vol.8 (1), p.16085-16085, Article 16085

2017

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New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

PLoS genetics, 2018-04, Vol.14 (4), p.e1007282-e1007282

2018

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MTBVAC from discovery to clinical trials in tuberculosis-endemic countries

Expert review of vaccines, 2017-06, Vol.16 (6), p.565-576

2017

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New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

PLoS pathogens, 2020-04, Vol.16 (4), p.e1008404-e1008404

2020

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Update on TB Vaccine Pipeline

Applied sciences, 2020-04, Vol.10 (7), p.2632

2020

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Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung

Nature communications, 2023-10, Vol.14 (1), p.6090-6090, Article 6090

2023

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Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial

The lancet respiratory medicine, 2015-12, Vol.3 (12), p.953-962

2015

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Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

Journal for immunotherapy of cancer, 2020-04, Vol.8 (1), p.e000528

2020

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Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis

Veterinary research (Paris), 2019-10, Vol.50 (1), p.82-82, Article 82

2019

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The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Molecular therapy. Nucleic acids, 2022-03, Vol.27, p.1235-1248

2022

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Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo

PloS one, 2016-04, Vol.11 (4), p.e0153028

2016

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Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

EBioMedicine, 2020-05, Vol.55, p.102761, Article 102761

2020

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Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference

PLoS pathogens, 2020-12, Vol.16 (12), p.e1009061-e1009061

2020

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Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

Cell reports (Cambridge), 2014-07, Vol.8 (2), p.420-429

2014

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Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally

iScience, 2024-02, Vol.27 (2), p.108869-108869, Article 108869

2024

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Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates

Frontiers in microbiology, 2020-06, Vol.11, p.1339-1339

2020

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MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG

Vaccine, 2021-12, Vol.39 (50), p.7277-7285

2021

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Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors

Journal for immunotherapy of cancer, 2022-07, Vol.10 (7), p.e004325

2022

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BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

EBioMedicine, 2021-03, Vol.65, p.103254-103254, Article 103254

2021

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MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.253-264

2019

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Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model

Allergy (Copenhagen), 2019-12, Vol.74 (12), p.2512-2514

2019

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A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component

Infection and immunity, 2014-08, Vol.82 (8), p.3446-3456

2014

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Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes

Cellular microbiology, 2015-11, Vol.17 (11), p.1537-1560

2015

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MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

MTBVAC from discovery to clinical trials in tuberculosis-endemic countries

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

Update on TB Vaccine Pipeline

Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung

Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial

Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference

Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally

Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates

MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG

Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors

BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

Determination of the Concentration of IgG against the Spike Receptor-Binding Domain That Predicts the Viral Neutralizing Activity of Convalescent Plasma and Serum against SARS-CoV-2

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model

A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component

Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes

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