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Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

Antimicrobial agents and chemotherapy, 2018-12, Vol.62 (12)

2018

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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Antimicrobial agents and chemotherapy, 2018-09, Vol.62 (9)

2018

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Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

Antimicrobial Agents and Chemotherapy, 2009-07, Vol.53 (7), p.2824-2833

2009

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A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6147-6153

2013

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Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1712-1719

2010

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Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.635-639

2014

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New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing

Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.996-1005

2013

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Silver Coordination Polymers for Prevention of Implant Infection: Thiol Interaction, Impact on Respiratory Chain Enzymes, and Hydroxyl Radical Induction

Antimicrobial Agents and Chemotherapy, 2010-10, Vol.54 (10), p.4208-4218

2010

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Depolarization, Bacterial Membrane Composition, and the Antimicrobial Action of Ceragenins

Antimicrobial Agents and Chemotherapy, 2010-09, Vol.54 (9), p.3708-3713

2010

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Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 2007-04, Vol.51 (4), p.1380-1385

2007

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Selective Advantage of Resistant Strains at Trace Levels of Antibiotics: a Simple and Ultrasensitive Color Test for Detection of Antibiotics and Genotoxic Agents

Antimicrobial Agents and Chemotherapy, 2011-03, Vol.55 (3), p.1204-1210

2011

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Systematic Review and Meta-Analysis of the Tolerability and Hepatotoxicity of Antifungals in Empirical and Definitive Therapy for Invasive Fungal Infection

Antimicrobial Agents and Chemotherapy, 2010-06, Vol.54 (6), p.2409-2419

2010

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Contribution of Oxidative Damage to Antimicrobial Lethality

Antimicrobial Agents and Chemotherapy, 2009-04, Vol.53 (4), p.1395-1402

2009

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Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.3720-3725

2009

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High Level of Cross-Resistance between Kanamycin, Amikacin, and Capreomycin among Mycobacterium tuberculosis Isolates from Georgia and a Close Relation with Mutations in the rrs Gene

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.5064-5068

2009

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Impact of Silver-Containing Wound Dressings on Bacterial Biofilm Viability and Susceptibility to Antibiotics during Prolonged Treatment

Antimicrobial Agents and Chemotherapy, 2010-12, Vol.54 (12), p.5120-5131

2010

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Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates

Antimicrobial Agents and Chemotherapy, 2005-08, Vol.49 (8), p.3264-3273

2005

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Effects of Tuberculosis, Race, and Human Gene SLCO1B1 Polymorphisms on Rifampin Concentrations

Antimicrobial Agents and Chemotherapy, 2010-10, Vol.54 (10), p.4192-4200

2010

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Therapeutic Efficacy of SQ641-NE against Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 2014-01, Vol.58 (1), p.587-589

2014

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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4432-4441

2008

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Copper and Quaternary Ammonium Cations Exert Synergistic Bactericidal and Antibiofilm Activity against Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2870-2881

2008

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Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics

Antimicrobial Agents and Chemotherapy, 2008-02, Vol.52 (2), p.427-434

2008

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RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.3952-3962

2009

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Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen

Antimicrobial Agents and Chemotherapy, 2006-11, Vol.50 (11), p.3674-3679

2006

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Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections

Antimicrobial Agents and Chemotherapy, 2011-02, Vol.55 (2), p.583-592

2011

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Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults

Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library

Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease

New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing

Silver Coordination Polymers for Prevention of Implant Infection: Thiol Interaction, Impact on Respiratory Chain Enzymes, and Hydroxyl Radical Induction

Depolarization, Bacterial Membrane Composition, and the Antimicrobial Action of Ceragenins

Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis

Selective Advantage of Resistant Strains at Trace Levels of Antibiotics: a Simple and Ultrasensitive Color Test for Detection of Antibiotics and Genotoxic Agents

Systematic Review and Meta-Analysis of the Tolerability and Hepatotoxicity of Antifungals in Empirical and Definitive Therapy for Invasive Fungal Infection

Contribution of Oxidative Damage to Antimicrobial Lethality

Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects

High Level of Cross-Resistance between Kanamycin, Amikacin, and Capreomycin among Mycobacterium tuberculosis Isolates from Georgia and a Close Relation with Mutations in the rrs Gene

Impact of Silver-Containing Wound Dressings on Bacterial Biofilm Viability and Susceptibility to Antibiotics during Prolonged Treatment

Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates

Effects of Tuberculosis, Race, and Human Gene SLCO1B1 Polymorphisms on Rifampin Concentrations

Therapeutic Efficacy of SQ641-NE against Mycobacterium tuberculosis

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Copper and Quaternary Ammonium Cations Exert Synergistic Bactericidal and Antibiofilm Activity against Pseudomonas aeruginosa

Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics

RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen

Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections

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