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Reversibility of a critical intraventricular conduction delay under flecainide and lacosamide by sodium bicarbonate

Innere Medizin (Heidelberg, Germany), 2024-08

2024

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Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity

British journal of pharmacology, 2024-07

2024

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Exploring the Interplay between Extracellular pH and Dronedarone's Pharmacological Effects on Cardiac Function

European journal of pharmacology, 2024-09, p.176980, Article 176980

2024

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Design of artificial biomimetic channels with Na+ permeation rate and selectivity potentially outperforming the natural sodium channel

Nano research, 2024-09, Vol.17 (9), p.8638-8646

2024

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Voltage-Gated K+ Channel Modulation by Marine Toxins: Pharmacological Innovations and Therapeutic Opportunities

Marine drugs, 2024-07, Vol.22 (8), p.350

2024

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Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Scientific reports, 2024-07, Vol.14 (1), p.15683-18, Article 15683

2024

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Development of new chiral 1,2,4-triazole-3-thiones and 1,3,4-thiadiazoles with promising in vivo anticonvulsant activity targeting GABAergic system and voltage-gated sodium channels (VGSCs)

Bioorganic chemistry, 2024-10, Vol.151, p.107662, Article 107662

2024

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Development and characterization of the mode-of-action of inhibitory and agonist peptides targeting the voltage-gated sodium channel SCN1B beta-subunit

Journal of molecular and cellular cardiology, 2024-09, Vol.194, p.32-45

2024

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Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

Structure (London), 2024-08

2024

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An artificial intelligence accelerated virtual screening platform for drug discovery

Nature communications, 2024-09, Vol.15 (1), p.7761-14, Article 7761

2024

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High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket

Nature communications, 2024-08, Vol.15 (1), p.6662-13, Article 6662

2024

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Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges

International journal of molecular sciences, 2024-06, Vol.25 (12), p.6467

2024

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Mapping structural distribution and gating-property impacts of disease-associated mutations in voltage-gated sodium channels

iScience, 2024-09, Vol.27 (9), p.110678, Article 110678

2024

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A Real-World Safety Profile in Neurological, Skin, and Sexual Disorders of Anti-Seizure Medications Using the Pharmacovigilance Database of the Korea Adverse Event Reporting System (KAERS)

Journal of clinical medicine, 2024-07, Vol.13 (13), p.3983

2024

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Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?

Drug delivery and translational research, 2024, Vol.14 (8), p.2112-2145

2024

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Conditional epithelial sodium channel (ENaC) over-expression in C57Bl6 mouse lung triggers innate immune responses via activation of high mobility group box 1 (HMGB1) signaling

Physiology (Bethesda, Md.), 2024-05, Vol.39 (S1)

2024

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The Role of Ion Channels and Intracellular Signaling Cascades in the Inhibitory Action of WIN 55,212-2 upon Hyperexcitation

Brain sciences, 2024-06, Vol.14 (7), p.668

2024

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Effect of Crude Extract from the Sea Anemone Bunodeopsis globulifera on Voltage-Gated Ion Channels from Central and Peripheral Murine Nervous Systems

Pharmaceuticals (Basel, Switzerland), 2024-07, Vol.17 (8), p.1006

2024

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The potential of marine natural products and their synthetic derivatives as drugs targeting ion channels

European journal of medicinal chemistry, 2024-10, Vol.276, p.116644, Article 116644

2024

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Peripherally targeted analgesia via AAV-mediated sensory neuron–specific inhibition of multiple pronociceptive sodium channels

The Journal of clinical investigation, 2024-07, Vol.134 (13), p.1-18

2024

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Voltage-gated sodium channels in cancers

Biomarker research, 2024-07, Vol.12 (1), p.1-24, Article 70

2024

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Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels

The Journal of clinical investigation, 2024-07, Vol.134 (13)

2024

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Scorpion Neurotoxin BeM9 Derivative Uncovers Unique Interaction Mode with Nav1.5 Sodium Channel Isoform

Russian journal of bioorganic chemistry, 2024-08, Vol.50 (4), p.1341-1350

2024

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Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7

International journal of biological macromolecules, 2024-10, Vol.278 (Pt 1), p.134219, Article 134219

2024

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A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

EFSA journal, 2024-08, Vol.22 (8), p.e8954-n/a

2024

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Reversibility of a critical intraventricular conduction delay under flecainide and lacosamide by sodium bicarbonate

Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity

Exploring the Interplay between Extracellular pH and Dronedarone's Pharmacological Effects on Cardiac Function

Design of artificial biomimetic channels with Na+ permeation rate and selectivity potentially outperforming the natural sodium channel

Voltage-Gated K+ Channel Modulation by Marine Toxins: Pharmacological Innovations and Therapeutic Opportunities

Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Development of new chiral 1,2,4-triazole-3-thiones and 1,3,4-thiadiazoles with promising in vivo anticonvulsant activity targeting GABAergic system and voltage-gated sodium channels (VGSCs)

Development and characterization of the mode-of-action of inhibitory and agonist peptides targeting the voltage-gated sodium channel SCN1B beta-subunit

Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

An artificial intelligence accelerated virtual screening platform for drug discovery

High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket

Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges

Mapping structural distribution and gating-property impacts of disease-associated mutations in voltage-gated sodium channels

A Real-World Safety Profile in Neurological, Skin, and Sexual Disorders of Anti-Seizure Medications Using the Pharmacovigilance Database of the Korea Adverse Event Reporting System (KAERS)

Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?

Conditional epithelial sodium channel (ENaC) over-expression in C57Bl6 mouse lung triggers innate immune responses via activation of high mobility group box 1 (HMGB1) signaling

The Role of Ion Channels and Intracellular Signaling Cascades in the Inhibitory Action of WIN 55,212-2 upon Hyperexcitation

Effect of Crude Extract from the Sea Anemone Bunodeopsis globulifera on Voltage-Gated Ion Channels from Central and Peripheral Murine Nervous Systems

The potential of marine natural products and their synthetic derivatives as drugs targeting ion channels

Peripherally targeted analgesia via AAV-mediated sensory neuron–specific inhibition of multiple pronociceptive sodium channels

Voltage-gated sodium channels in cancers

Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels

Scorpion Neurotoxin BeM9 Derivative Uncovers Unique Interaction Mode with Nav1.5 Sodium Channel Isoform

Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7

A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

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