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Neurosteroids Allopregnanolone Sulfate and Pregnanolone Sulfate Have Diverse Effect on the α Subunit of the Neuronal Voltage-gated Sodium Channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 Expressed in Xenopus Oocytes

Anesthesiology (Philadelphia), 2014-09, Vol.121 (3), p.620-631

2014

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Modulation of peripheral Na+ channels and neuronal firing by n-butyl-p-aminobenzoate

European journal of pharmacology, 2014-03, Vol.727, p.158-166

2014

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Antidepressants inhibit Na v 1.3, Na v 1.7, and Na v 1.8 neuronal voltage-gated sodium channels more potently than Na v 1.2 and Na v 1.6 channels expressed in Xenopus oocytes

Naunyn-Schmiedeberg's archives of pharmacology, 2017-12, Vol.390 (12), p.1255

2017

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High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na + channel complex

Scientific reports, 2019-11, Vol.9 (1), p.16890-15, Article 16890

2019

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa v 1.7

The Journal of biological chemistry, 2020-01, Vol.295 (5), p.1315-1327

2020

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Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na V 1.9, Na V 1.7 and Na V 1.1

Marine drugs, 2017-08, Vol.15 (9)

2017

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Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Marine drugs, 2016-02, Vol.14 (2), p.36

2016

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Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough

Lung, 2014-02, Vol.192 (1), p.15

2014

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Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5

Journal of biomolecular screening, 2016-06, Vol.21 (5), p.480-489

2016

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Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade

The Journal of general physiology, 2007-02, Vol.129 (2), p.161-173

2007

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Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

Expert opinion on therapeutic targets, 2016-08, Vol.20 (8), p.975-983

2016

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Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (17), p.6704

2012

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Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Brain (London, England : 1878), 2016-08, Vol.139 (Pt 8), p.2164-2181

2016

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Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.E1857-E1865

2017

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Contribution of tetrodotoxin-sensitive, voltage-gated sodium channels (Na V 1) to action potential discharge from mouse esophageal tension mechanoreceptors

American journal of physiology. Regulatory, integrative and comparative physiology, 2021-11, Vol.321 (5), p.R672-R686

2021

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ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

Molecular pharmacology, 2008-11, Vol.74 (5), p.1476

2008

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Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

PloS one, 2016-11, Vol.11 (11), p.e0166143

2016

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Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons

European journal of pharmacology, 2021-11, Vol.910, p.174449, Article 174449

2021

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Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure

American journal of physiology. Renal physiology, 2019-05, Vol.316 (5), p.F807-F813

2019

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Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles

Muscle & nerve, 2021-01, Vol.63 (1), p.141-150

2021

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Modulation of a voltage-gated Na+channel by sevoflurane involves multiple sites and distinct mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.6726-6731

2014

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Saxitoxin

Angewandte Chemie (International ed.), 2014-06, Vol.53 (23), p.5760-5784

International ed. in English, 2014

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A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Nature communications, 2014-07, Vol.5 (1), p.4350-4350, Article 4350

2014

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Insect sodium channels and insecticide resistance

Invertebrate neuroscience, 2007-03, Vol.7 (1), p.17-30

Dong, Ke

2007

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Neurosteroids Allopregnanolone Sulfate and Pregnanolone Sulfate Have Diverse Effect on the α Subunit of the Neuronal Voltage-gated Sodium Channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 Expressed in Xenopus Oocytes

Modulation of peripheral Na+ channels and neuronal firing by n-butyl-p-aminobenzoate

Antidepressants inhibit Na v 1.3, Na v 1.7, and Na v 1.8 neuronal voltage-gated sodium channels more potently than Na v 1.2 and Na v 1.6 channels expressed in Xenopus oocytes

High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na + channel complex

Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa v 1.7

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na V 1.9, Na V 1.7 and Na V 1.1

Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough

Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

Contribution of tetrodotoxin-sensitive, voltage-gated sodium channels (Na V 1) to action potential discharge from mouse esophageal tension mechanoreceptors

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons

Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure

Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles

Modulation of a voltage-gated Na+channel by sevoflurane involves multiple sites and distinct mechanisms

Saxitoxin

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Insect sodium channels and insecticide resistance

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

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