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Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6052-6063

2024

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Repeated sprint training in hypoxia induces specific skeletal muscle adaptations through S100A protein signaling

The FASEB journal, 2024-04, Vol.38 (8), p.e23615-n/a

2024

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Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway

Amino acids, 2024-12, Vol.56 (1), p.32

2024

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Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells

European journal of pharmacology, 2024-05, Vol.971, p.176552-176552, Article 176552

2024

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Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue

Bioorganic & medicinal chemistry letters, 2024-05, Vol.104, p.129728-129728, Article 129728

2024

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Network pharmacology-based investigation of the effects of Shenqi Fuzheng injection on glioma proliferation and migration via the SRC/PI3K/AKT signaling pathway

Journal of ethnopharmacology, 2024-06, Vol.328, p.118128-118128, Article 118128

2024

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RACGAP1 promotes lung cancer cell proliferation through the PI3K/AKT signaling pathway

Scientific reports, 2024-04, Vol.14 (1), p.8694-8694

2024

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Photobiomodulation therapy moderates cancer cachexia-associated muscle wasting through activating PI3K/AKT/FoxO3a pathway

Apoptosis (London), 2024-04, Vol.29 (5-6), p.663-680

2024

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Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway

Journal of hazardous materials, 2024-05, Vol.470, p.134129-134129, Article 134129

2024

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Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization

European journal of pharmacology, 2024-06, Vol.972, p.176560-176560, Article 176560

2024

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A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer

Experimental cell research, 2024-04, Vol.437 (2), p.114012-114012, Article 114012

2024

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Effect of miR-1297 on Kidney Injury in Rats with Diabetic Nephropathy through the PTEN/PI3K/AKT Pathway

Archivos españoles de urología, 2024-03, Vol.77 (2), p.183-192

2024

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MiRNA-21-5p induces chicken hepatic lipogenesis by targeting NFIB and KLF3 to suppress the PI3K/AKT signaling pathway

Journal of animal science, 2024-01, Vol.102

2024

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The cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts

Scientific reports, 2024-03, Vol.14 (1), p.7559-7559

2024

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OPN silencing reduces hypoxic pulmonary hypertension via PI3K-AKT-induced protective autophagy

Scientific reports, 2024-04, Vol.14 (1), p.8670-8670

2024

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Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation

Scientific reports, 2024-04, Vol.14 (1), p.9167

2024

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FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

Cell death & disease, 2024-04, Vol.15 (4), p.282-14

2024

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Identification of differentially expressed mRNA/lncRNA modules in acutely regorafenib-treated sorafenib-resistant Huh7 hepatocellular carcinoma cells

PloS one, 2024-04, Vol.19 (4), p.e0301663-e0301663

2024

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Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation

Cell death & disease, 2024-04, Vol.15 (4), p.252-252

2024

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Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes

Particle and fibre toxicology, 2024-04, Vol.21 (1), p.21

2024

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Transcranial direct current stimulation promotes angiogenesis and improves neurological function via the OXA-TF-AKT/ERK signaling pathway in traumatic brain injury

Aging (Albany, NY.), 2024-04, Vol.16 (7), p.6566-6587

2024

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The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances

Cell biochemistry and function, 2024-04, Vol.42 (3), p.e3998-n/a

2024

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Knockdown of NCAPD3 inhibits the tumorigenesis of non-small cell lung cancer by regulation of the PI3K/Akt pathway

BMC cancer, 2024-04, Vol.24 (1), p.408-408

2024

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TNF-α signals through ITK-Akt-mTOR to drive CD4 + T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis

Science signaling, 2024-04, Vol.17 (833), p.eadg5678

2024

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Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype

Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises

Repeated sprint training in hypoxia induces specific skeletal muscle adaptations through S100A protein signaling

Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway

Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells

Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue

Network pharmacology-based investigation of the effects of Shenqi Fuzheng injection on glioma proliferation and migration via the SRC/PI3K/AKT signaling pathway

RACGAP1 promotes lung cancer cell proliferation through the PI3K/AKT signaling pathway

Photobiomodulation therapy moderates cancer cachexia-associated muscle wasting through activating PI3K/AKT/FoxO3a pathway

Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway

Celastrol alleviates airway hyperresponsiveness and inflammation in obese asthma through mediation of alveolar macrophage polarization

A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer

Effect of miR-1297 on Kidney Injury in Rats with Diabetic Nephropathy through the PTEN/PI3K/AKT Pathway

MiRNA-21-5p induces chicken hepatic lipogenesis by targeting NFIB and KLF3 to suppress the PI3K/AKT signaling pathway

The cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts

OPN silencing reduces hypoxic pulmonary hypertension via PI3K-AKT-induced protective autophagy

Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation

FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

Identification of differentially expressed mRNA/lncRNA modules in acutely regorafenib-treated sorafenib-resistant Huh7 hepatocellular carcinoma cells

Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation

Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes

Transcranial direct current stimulation promotes angiogenesis and improves neurological function via the OXA-TF-AKT/ERK signaling pathway in traumatic brain injury

The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances

Knockdown of NCAPD3 inhibits the tumorigenesis of non-small cell lung cancer by regulation of the PI3K/Akt pathway

TNF-α signals through ITK-Akt-mTOR to drive CD4 + T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis

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