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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

The Journal of biological chemistry, 2018-05, Vol.293 (18), p.7040-7057

2018

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COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

The Journal of pharmacology and experimental therapeutics, 2021-05, Vol.377 (2), p.265

2021

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Phenytoin and phenobarbital inhibit human HERG potassium channels

Epilepsy research, 2003-06, Vol.55 (1), p.147-157

2003

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

Journal of ethnopharmacology, 2021-08, Vol.276, p.114168-114168, Article 114168

2021

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Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region

Biochemical and biophysical research communications, 2020-11, Vol.532 (2), p.265-270

2020

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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1283-1291

2019

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An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Bioorganic & medicinal chemistry letters, 2019-12, Vol.29 (23), p.126681, Article 126681

2019

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Regulation of ion channel localization and phosphorylation by neuronal activity

Nature neuroscience, 2004-07, Vol.7 (7), p.711-718

2004

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A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels

British journal of pharmacology, 2017-12, Vol.174 (23), p.4396-4408

2017

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A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Angewandte Chemie (International ed.), 2017-09, Vol.56 (38), p.11520-11524

International ed. in English, 2017

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Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

The Journal of pharmacology and experimental therapeutics, 2012-09, Vol.342 (3), p.642

2012

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Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

Organic letters, 2016-05, Vol.18 (9), p.2166-2169

2016

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A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

FEBS letters, 2012-11, Vol.586 (22), p.3996-4001

2012

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ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats

Experimental neurology, 2012-05, Vol.235 (1), p.282-296

2012

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A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs

The Journal of biological chemistry, 2021-01, Vol.296, p.100302-100302, Article 100302

2021

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Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

The Journal of neuroscience, 2009-06, Vol.29 (23), p.7474-7488

2009

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Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels

Circulation research, 2009-04, Vol.104 (8), p.987-994

2009

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Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

Journal of molecular and cellular cardiology, 2015-08, Vol.85, p.71-78

2015

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Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels

Circulation research, 2012-01, Vol.110 (2), p.285-294

2012

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Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

The Journal of neuroscience, 2015-09, Vol.35 (38), p.13206-13218

2015

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Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

The Journal of neuroscience, 2010-01, Vol.30 (2), p.491-504

2010

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Effects of a Highly Selective Acetylcholine-Activated K+ Channel Blocker on Experimental Atrial Fibrillation

Circulation. Arrhythmia and electrophysiology, 2011-02, Vol.4 (1), p.94-102

2011

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Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3968-3973

2014

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Thallium-sensitive fluorescent assay reveals loperamide as a new inhibitor of the potassium channel Kv10.1

Pharmacological reports, 2021-12, Vol.73 (6), p.1744-1753

2021

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

Phenytoin and phenobarbital inhibit human HERG potassium channels

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Regulation of ion channel localization and phosphorylation by neuronal activity

A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels

A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats

A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs

Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels

Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

Effects of a Highly Selective Acetylcholine-Activated K+ Channel Blocker on Experimental Atrial Fibrillation

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

Thallium-sensitive fluorescent assay reveals loperamide as a new inhibitor of the potassium channel Kv10.1

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