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1.03 - Major Drug Introductions

Comprehensive Medicinal Chemistry II, 2007, Vol.1, p.97-249

Kennewell, P.D.

Second Edition, 2007

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1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a potent and highly selective small molecule blocker of the large-conductance voltage-gated and calcium-dependent K+ channel

The Journal of pharmacology and experimental therapeutics, 2008-10, Vol.327 (1), p.168-177

2008

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1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex

Translational psychiatry, 2019-11, Vol.9 (1), p.281-10, Article 281

2019

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1.25 Postmarketing Surveillance

Comprehensive Medicinal Chemistry II, 2007, Vol.1, p.755-777

Li Wan Po, A

2007

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1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3247-3256

2013

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1,4-Benzothiazine ATP-Sensitive Potassium Channel Openers: Modifications at the C‑2 and C‑6 Positions

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4718-4728

2013

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1,4-Diazabicyclo[2.2.2]octane Derivatives: A Novel Class of Voltage-Gated Potassium Channel Blockers

Molecular pharmacology, 2006-03, Vol.69 (3), p.718-726

2006

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1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Oxidative medicine and cellular longevity, 2016-01, Vol.2016 (2016), p.1-35

2016

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The 1,4-dihydropyridine nucleus: a pharmacophoric template part 1. Actions at ion channels

Mini reviews in medicinal chemistry, 2003-05, Vol.3 (3), p.215-223

Triggle, David J

2003

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1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs

Current medicinal chemistry, 2011-11, Vol.18 (32), p.4901-4922

2011

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[1,5]-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1265

2020

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1-[6-[[(17Î²)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion

Molecular pharmacology, 2008-11, Vol.74 (5), p.1203-1214

2008

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1. An Investigation into the Effects of Novel DBM and PAM Effectors on Catecholamine Metabolism and Amidation in Adrenal Chromaffin Cell Culture. 2. Microbial Production of Poly-β-hydroxybutyric Acid from D-xylose and Lactose using Pseudomonas cepacia

Young, Frederick Kwai

1995

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1-Benzyl-1,2,3,4-Tetrahydro-β-Carboline as Channel Blocker of N-Methyl-d-Aspartate Receptors

Chemical biology & drug design, 2012-04, Vol.79 (4), p.594-599

2012

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1-Ethyl-2-benzimidazolinone (EBIO) suppresses epileptiform activity in in vitro hippocampus

Neuropharmacology, 2005-09, Vol.49 (3), p.376-388

2005

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1-Ethyl-2-benzimidazolinone stimulates endothelial K Ca channels and nitric oxide formation in rat mesenteric vessels

European journal of pharmacology, 1999-08, Vol.379 (2), p.151-159

Adeagbo, Ayotunde S.O

1999

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1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels

European journal of pharmacology, 1999-08, Vol.379 (2-3), p.151-159

Adeagbo, A S

1999

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ET-1 inhibits B-16 murine melanoma cell migration by decreasing K+ currents

Cell motility and the cytoskeleton, 2004-06, Vol.58 (2), p.127-136

2004

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1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Molecular brain, 2020-05, Vol.13 (1), p.73-73, Article 73

2020

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1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

Journal of neuroinflammation, 2016-08, Vol.13 (1), p.205-205, Article 205

2016

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A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms

Circulation research, 2001-03, Vol.88 (5), p.520-528

2001

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A 1 receptors mediate adenosine inhibitory effects in mouse ileum via activation of potassium channels

Life sciences (1973), 2009, Vol.84 (21), p.772-778

2009

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10 - Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons

Multiple Sclerosis As A Neuronal Disease, 2005, p.145-152

Bever, Christopher T.

2005

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10 Neurologic disorders

Monthly prescribing reference, 2016-06, Vol.32 (6), p.160

2016

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10 Neurologic disorders

Monthly prescribing reference, 2015-06, Vol.31 (6), p.184

2015

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1.03 - Major Drug Introductions

1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a potent and highly selective small molecule blocker of the large-conductance voltage-gated and calcium-dependent K+ channel

1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex

1.25 Postmarketing Surveillance

1,4,2-Benzo/pyridodithiazine 1,1-Dioxides Structurally Related to the ATP-Sensitive Potassium Channel Openers 1,2,4-Benzo/pyridothiadiazine 1,1-Dioxides Exert a Myorelaxant Activity Linked to a Distinct Mechanism of Action

1,4-Benzothiazine ATP-Sensitive Potassium Channel Openers: Modifications at the C‑2 and C‑6 Positions

1,4-Diazabicyclo[2.2.2]octane Derivatives: A Novel Class of Voltage-Gated Potassium Channel Blockers

1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

The 1,4-dihydropyridine nucleus: a pharmacophoric template part 1. Actions at ion channels

1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs

[1,5]-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

1-[6-[[(17Î²)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion

1. An Investigation into the Effects of Novel DBM and PAM Effectors on Catecholamine Metabolism and Amidation in Adrenal Chromaffin Cell Culture. 2. Microbial Production of Poly-β-hydroxybutyric Acid from D-xylose and Lactose using Pseudomonas cepacia

1-Benzyl-1,2,3,4-Tetrahydro-β-Carboline as Channel Blocker of N-Methyl-d-Aspartate Receptors

1-Ethyl-2-benzimidazolinone (EBIO) suppresses epileptiform activity in in vitro hippocampus

1-Ethyl-2-benzimidazolinone stimulates endothelial K Ca channels and nitric oxide formation in rat mesenteric vessels

1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels

ET-1 inhibits B-16 murine melanoma cell migration by decreasing K+ currents

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms

A 1 receptors mediate adenosine inhibitory effects in mouse ileum via activation of potassium channels

10 - Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons

10 Neurologic disorders

10 Neurologic disorders

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