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Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls

Journal of biomolecular screening, 2015-10, Vol.20 (9), p.1055-1073

2015

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KCNQ2/3/5 channels in dorsal root ganglion neurons can be therapeutic targets of neuropathic pain in diabetic rats

Molecular pain, 2018-01, Vol.14, p.1744806918793229

2018

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

International journal of toxicology, 2019-01, Vol.38 (1), p.23-32

2019

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Effects of the KIR7.1 Blocker VU590 on Spontaneous and Agonist-Induced Contractions of Human Pregnant Myometrium

Reproductive sciences (Thousand Oaks, Calif.), 2017-10, Vol.24 (10), p.1402-1409

2017

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Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)

Multiple sclerosis, 2020-04, Vol.26 (4), p.505-508

2020

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Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain

Molecular pain, 2014-02, Vol.10 (1), p.15-15

2014

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A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1

Journal of biomolecular screening, 2015-07, Vol.20 (6), p.739-747

2015

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Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels

Journal of biomolecular screening, 2011-01, Vol.16 (1), p.101-111

2011

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The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel

Molecular pain, 2016, Vol.12, p.174480691666394

2016

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Development of a Novel Cell-Based Assay System for High-Throughput Screening of Compounds Acting on Background Two-Pore Domain K+ Channels

SLAS discovery, 2019-07, Vol.24 (6), p.641-652

2019

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A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

Journal of biomolecular screening, 2004-12, Vol.9 (8), p.671-677

2004

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Effects of cooling temperatures and low pH on membrane properties and voltage-dependent currents of rat nociceptive-like trigeminal ganglion neurons

Molecular pain, 2018-01, Vol.14, p.1744806918814350-1744806918814350

2018

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Effects of Potassium Channel Blockers on Changes in Refractoriness of Atrial Cardiomyocytes Induced by Stretch

Experimental biology and medicine (Maywood, N.J.), 2009-07, Vol.234 (7), p.779-784

2009

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Adenosine A Receptor Antagonist and Mitochondrial ATP-Sensitive Potassium Channel Blocker Attenuate the Tolerance to Focal Cerebral Ischemia in Rats

Journal of cerebral blood flow and metabolism, 2004-07, Vol.24 (7), p.771-779

2004

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Large Conductance Calcium-Activated Potassium Channels (BKCa) Modulate Trigeminovascular Nociceptive Transmission

Cephalalgia, 2009-12, Vol.29 (12), p.1242-1258

2009

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Photoperiod Modulates Fast Delayed Rectifier Potassium Currents in the Mammalian Circadian Clock

ASN neuro, 2016-10, Vol.8 (5), p.175909141667077

2016

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Electrophysiological Characterization and Antiarrhythmic Efficacy of the Mixed Potassium Channel-Blocking Antiarrhythmic Agent AZ13395438 In Vitro and In Vivo

Journal of cardiovascular pharmacology and therapeutics, 2013-05, Vol.18 (3), p.290-300

2013

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Tizanidine (Zanaflex): A Muscle Relaxant That May Prolong the QT Interval by Blocking IKr

Journal of cardiovascular pharmacology and therapeutics, 2012-03, Vol.17 (1), p.102-109

2012

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Large Conductance Ca2+-Activated K+ Channels Modulate Uterine α1-Adrenergic Sensitivity in Ovine Pregnancy

Reproductive sciences (Thousand Oaks, Calif.), 2014-04, Vol.21 (4), p.456-464

2014

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High-Throughput Screening for Kv1.3 Channel Blockers Using an Improved FLIPR-Based Membrane-Potential Assay

Journal of biomolecular screening, 2010-02, Vol.15 (2), p.185-195

2010

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Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

Journal of biomolecular screening, 2004-10, Vol.9 (7), p.588-597

2004

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Inactivation Properties of Sodium Channel Nav1.8 Maintain Action Potential Amplitude in Small DRG Neurons in the Context of Depolarization

Molecular pain, 2007-05, Vol.3 (1), p.12-12

2007

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Both Mitochondrial KATP Channel Opening and Sarcolemmal KATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

Journal of cardiovascular pharmacology and therapeutics, 2010-12, Vol.15 (4), p.403-411

2010

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Validation of a Medium-Throughput Electrophysiological Assay for KCNQ2/3 Channel Enhancers Using IonWorks HT

Journal of biomolecular screening, 2007-12, Vol.12 (8), p.1059-1067

2007

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Myocardial Impairment in Chronic Hypoxia is Abolished by Short Aeration Episodes: Involvement of K+ATP Channels

Experimental biology and medicine (Maywood, N.J.), 2004-12, Vol.229 (11), p.1196-1205

2004

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Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls

KCNQ2/3/5 channels in dorsal root ganglion neurons can be therapeutic targets of neuropathic pain in diabetic rats

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

Effects of the KIR7.1 Blocker VU590 on Spontaneous and Agonist-Induced Contractions of Human Pregnant Myometrium

Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)

Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain

A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1

Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels

The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel

Development of a Novel Cell-Based Assay System for High-Throughput Screening of Compounds Acting on Background Two-Pore Domain K+ Channels

A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

Effects of cooling temperatures and low pH on membrane properties and voltage-dependent currents of rat nociceptive-like trigeminal ganglion neurons

Effects of Potassium Channel Blockers on Changes in Refractoriness of Atrial Cardiomyocytes Induced by Stretch

Adenosine A Receptor Antagonist and Mitochondrial ATP-Sensitive Potassium Channel Blocker Attenuate the Tolerance to Focal Cerebral Ischemia in Rats

Large Conductance Calcium-Activated Potassium Channels (BKCa) Modulate Trigeminovascular Nociceptive Transmission

Photoperiod Modulates Fast Delayed Rectifier Potassium Currents in the Mammalian Circadian Clock

Electrophysiological Characterization and Antiarrhythmic Efficacy of the Mixed Potassium Channel-Blocking Antiarrhythmic Agent AZ13395438 In Vitro and In Vivo

Tizanidine (Zanaflex): A Muscle Relaxant That May Prolong the QT Interval by Blocking IKr

Large Conductance Ca2+-Activated K+ Channels Modulate Uterine α1-Adrenergic Sensitivity in Ovine Pregnancy

High-Throughput Screening for Kv1.3 Channel Blockers Using an Improved FLIPR-Based Membrane-Potential Assay

Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

Inactivation Properties of Sodium Channel Nav1.8 Maintain Action Potential Amplitude in Small DRG Neurons in the Context of Depolarization

Both Mitochondrial KATP Channel Opening and Sarcolemmal KATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

Validation of a Medium-Throughput Electrophysiological Assay for KCNQ2/3 Channel Enhancers Using IonWorks HT

Myocardial Impairment in Chronic Hypoxia is Abolished by Short Aeration Episodes: Involvement of K+ATP Channels

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