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Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism

Science (American Association for the Advancement of Science), 2016-08, Vol.353 (6300), p.664-669

2016

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Ultrasound modulates ion channel currents

Scientific reports, 2016-04, Vol.6 (1), p.24170-24170, Article 24170

2016

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Potassium channel dysfunction in human neuronal models of Angelman syndrome

Science (American Association for the Advancement of Science), 2019-12, Vol.366 (6472), p.1486-1492

2019

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Photochromic Blockers of Voltage-Gated Potassium Channels

Angewandte Chemie (International ed.), 2009-01, Vol.48 (48), p.9097-9101

2009

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Structure-activity relationship studies of four novel 4-aminopyridine K + channel blockers

Scientific reports, 2020-01, Vol.10 (1), p.52-52, Article 52

2020

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Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

PloS one, 2017-07, Vol.12 (7), p.e0180762-e0180762

2017

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Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

British journal of pharmacology, 2021-07, Vol.178 (13), p.2617-2631

2021

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Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Canadian journal of physiology and pharmacology, 2023-01, Vol.101 (1), p.41

2023

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Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5963), p.348-351

2010

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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Proceedings of the National Academy of Sciences - PNAS, 2023-01, Vol.120 (2), p.e2211977120-e2211977120

2023

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K Ca channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Scientific reports, 2021-09, Vol.11 (1), p.18330

2021

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Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

The Journal of general physiology, 2019-02, Vol.151 (2), p.214-230

2019

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Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

Journal of chemical information and modeling, 2023-05, Vol.63 (10), p.3043-3053

2023

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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Crystal Structure of the Human K2P TRAAK, a Lipid-and Mechano-Sensitive K⁺ Ion Channel

Science (American Association for the Advancement of Science), 2012-01, Vol.335 (6067), p.436-441

2012

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Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca²⁺ events, and IKCₐ channels, reducing arteriolar tone

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.18174-18179

2012

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

PloS one, 2020-11, Vol.15 (11), p.e0234946

2020

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Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

Pharmacology & therapeutics (Oxford), 2006-07, Vol.111 (1), p.224-259

2006

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Novel cell-free high-throughput screening method for pharmacological tools targeting K⁺ channels

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (20), p.5748-5753

2016

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KATP Channels in the Cardiovascular System

Physiological reviews, 2016-01, Vol.96 (1), p.177-252

2016

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Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.5916

2015

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Discovery of K V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal research reviews, 2021-07, Vol.41 (4), p.2423-2473

2021

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Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

Science (American Association for the Advancement of Science), 2009-12, Vol.326 (5960), p.1668-1674

2009

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Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR

Nature, 2006-04, Vol.440 (7086), p.959-962

2006

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Purlisin, a toxin‐like defensin derived from clinical pathogenic fungus Purpureocillium lilacinum with both antimicrobial and potassium channel inhibitory activities

The FASEB journal, 2020-11, Vol.34 (11), p.15093-15107

2020

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Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism

Ultrasound modulates ion channel currents

Potassium channel dysfunction in human neuronal models of Angelman syndrome

Photochromic Blockers of Voltage-Gated Potassium Channels

Structure-activity relationship studies of four novel 4-aminopyridine K + channel blockers

Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

K Ca channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Crystal Structure of the Human K2P TRAAK, a Lipid-and Mechano-Sensitive K⁺ Ion Channel

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca²⁺ events, and IKCₐ channels, reducing arteriolar tone

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

Novel cell-free high-throughput screening method for pharmacological tools targeting K⁺ channels

KATP Channels in the Cardiovascular System

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

Discovery of K V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR

Purlisin, a toxin‐like defensin derived from clinical pathogenic fungus Purpureocillium lilacinum with both antimicrobial and potassium channel inhibitory activities

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