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Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons

Cell host & microbe, 2010-10, Vol.8 (4), p.320-330

2010

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G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

The Journal of biological chemistry, 2016-12, Vol.291 (53), p.27160-27169

2016

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Insulin Enhances Gene Expression of Midnolin , a Novel Genetic Risk Factor for Parkinson's Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells

The Journal of pharmacology and experimental therapeutics, 2022-05, Vol.381 (2), p.68

2022

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Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

Toxicology letters, 2015-09, Vol.237 (3), p.181-190

2015

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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.317-328

2012

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Siglec‐15 Regulates Osteoclast Differentiation by Modulating RANKL‐Induced Phosphatidylinositol 3‐Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

Journal of bone and mineral research, 2013-12, Vol.28 (12), p.2463-2475

2013

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Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Molecular and cellular endocrinology, 2017-09, Vol.452, p.44-56

2017

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Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Diabetes (New York, N.Y.), 2017-07, Vol.66 (7), p.1807-1818

2017

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Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Journal of cardiovascular pharmacology, 2022-09, Vol.80 (3), p.442

2022

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Effects of d‑Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats

Journal of agricultural and food chemistry, 2015-07, Vol.63 (26), p.6019-6026

2015

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MicroRNA-363-3p promotes apoptosis in response to cadmium-induced renal injury by down-regulating phosphoinositide 3-kinase expression

Toxicology letters, 2021-07, Vol.345, p.12-23

2021

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Discovery of a Phosphoinositide 3‑Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1555-1567

2017

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Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway

Life sciences (1973), 2020-02, Vol.242, p.117151, Article 117151

2020

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AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6026), p.247-251

2011

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The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension

American journal of physiology. Regulatory, integrative and comparative physiology, 2022-12, Vol.323 (6), p.R861-R874

2022

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The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

Molecular immunology, 2018-02, Vol.94, p.7-17

2018

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Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats

Toxicology and applied pharmacology, 2014-06, Vol.277 (2), p.155-163

2014

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Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Bioengineered, 2022-04, Vol.13 (4), p.11192-11201

2022

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Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Brain research, 2013-02, Vol.1494, p.1-8

2013

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DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway

American journal of physiology: endocrinology and metabolism, 2021-03, Vol.320 (3), p.E598-E608

2021

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Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Journal of ethnopharmacology, 2022-05, Vol.289, p.115021, Article 115021

2022

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Electroacupuncture Pretreatment at Neiguan (PC6) attenuates autophagy in rats with myocardial ischemia reperfusion through the phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin pathway

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2021-06, Vol.41 (3), p.455

2021

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Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Aging (Albany, NY.), 2020-04, Vol.12 (8), p.6852-6864

2020

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C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

Scientific reports, 2019-09, Vol.9 (1), p.12683-14, Article 12683

2019

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Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal Ischemia/Reperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

Oxidative medicine and cellular longevity, 2020, Vol.2020, p.6120194-14

2020

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Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons

G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

Insulin Enhances Gene Expression of Midnolin , a Novel Genetic Risk Factor for Parkinson's Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells

Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

Siglec‐15 Regulates Osteoclast Differentiation by Modulating RANKL‐Induced Phosphatidylinositol 3‐Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle

Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Effects of d‑Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats

MicroRNA-363-3p promotes apoptosis in response to cadmium-induced renal injury by down-regulating phosphoinositide 3-kinase expression

Discovery of a Phosphoinositide 3‑Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension

The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats

Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Electroacupuncture Pretreatment at Neiguan (PC6) attenuates autophagy in rats with myocardial ischemia reperfusion through the phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin pathway

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal Ischemia/Reperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

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