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Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer

Cancer letters, 2015-04, Vol.359 (1), p.47-56

2015

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Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Journal of clinical oncology, 2019-03, Vol.37 (9), p.741-750

2019

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Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Seminars in cancer biology, 2022-05, Vol.80, p.1-17

2022

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Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling

Clinical cancer research, 2012-08, Vol.18 (15), p.4104-4113

2012

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The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review)

International journal of oncology, 2015-08, Vol.47 (2), p.429-436

2015

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Management of adverse events associated with idelalisib treatment: expert panel opinion

Leukemia & lymphoma, 2015-10, Vol.56 (10), p.2779-2786

2015

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Targeting the Phosphatidylinositol 3‐Kinase Signaling Pathway in Breast Cancer

The oncologist (Dayton, Ohio), 2011-01, Vol.16 (4), p.404-414

2011

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Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

Cancer discovery, 2016-08, Vol.6 (8), p.870-885

2016

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The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients

Oncotarget, 2010-06, Vol.1 (2), p.89-103

2010

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Luminal B breast cancer: molecular characterization, clinical management, and future perspectives

Journal of clinical oncology, 2014-09, Vol.32 (25), p.2794-2803

2014

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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.317-328

2012

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

International journal of cancer, 2012-04, Vol.130 (7), p.1695-1705

2012

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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

Oncotarget, 2016-05, Vol.7 (22), p.33440-33450

2016

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circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Molecular cancer, 2020-05, Vol.19 (1), p.82-82, Article 82

2020

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Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

Breast cancer research and treatment, 2018-06, Vol.169 (3), p.397-406

2018

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Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-kinase (PI3K) Signaling Pathways in Medulloblastoma Cell Lines

Anticancer research, 2020-01, Vol.40 (1), p.53-66

2020

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Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

JNCI : Journal of the National Cancer Institute, 2017-01, Vol.109 (1), p.djw189

2017

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Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models

Clinical cancer research, 2010-07, Vol.16 (14), p.3670-3683

2010

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KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation

Journal of clinical oncology, 2015-08, Vol.33 (22), p.e93-e96

2015

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

Cancer discovery, 2011-07, Vol.1 (2), p.170-185

2011

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Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer

Cancer treatment reviews, 2014-08, Vol.40 (7), p.862-871

Ciruelos Gil, Eva Maria

2014

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Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

Cancer treatment reviews, 2013-12, Vol.39 (8), p.935-946

2013

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Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes

Breast cancer research : BCR, 2019-08, Vol.21 (1), p.90-90, Article 90

2019

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Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling

The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review)

Management of adverse events associated with idelalisib treatment: expert panel opinion

Targeting the Phosphatidylinositol 3‐Kinase Signaling Pathway in Breast Cancer

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial

The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients

Luminal B breast cancer: molecular characterization, clinical management, and future perspectives

Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-kinase (PI3K) Signaling Pathways in Medulloblastoma Cell Lines

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3' Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models

KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes

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