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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

Oncotarget, 2016-05, Vol.7 (22), p.33440-33450

2016

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PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion

Oncotarget, 2017-01, Vol.8 (5), p.8559-8573

2017

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EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy

Oncotarget, 2017-07, Vol.8 (30), p.48820-48831

2017

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EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect

Oncotarget, 2017-02, Vol.8 (6), p.9557-9571

2017

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Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells

Oncotarget, 2011-11, Vol.2 (11), p.833-849

2011

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The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

Oncotarget, 2015-09, Vol.6 (28), p.25520-25532

2015

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A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo

Oncotarget, 2014-06, Vol.5 (11), p.3836-3848

2014

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Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses

Oncotarget, 2017-04, Vol.8 (14), p.23551-23563

2017

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Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

Oncotarget, 2016-01, Vol.7 (2), p.1395-1407

2016

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Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion

Oncotarget, 2016-04, Vol.7 (14), p.17854-17869

2016

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The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells

Oncotarget, 2016-01, Vol.7 (2), p.1569-1583

2016

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Enolase-1 is a therapeutic target in endometrial carcinoma

Oncotarget, 2015-06, Vol.6 (17), p.15610-15627

2015

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Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling

Oncotarget, 2017-03, Vol.8 (10), p.17059-17069

2017

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p85α promotes nucleolin transcription and subsequently enhances EGFR mRNA stability and EGF-induced malignant cellular transformation

Oncotarget, 2016-03, Vol.7 (13), p.16636-16649

2016

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The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction

Oncotarget, 2016-01, Vol.7 (2), p.1516-1528

2016

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Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway

Oncotarget, 2015-10, Vol.6 (33), p.34859-34874

2015

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Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

Oncotarget, 2011-12, Vol.2 (12), p.1314-1321

2011

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Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

Oncotarget, 2016-06, Vol.7 (26), p.39784-39795

2016

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A beta version of life: p110β takes center stage

Oncotarget, 2010-12, Vol.1 (8), p.729-733

2010

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Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit

Oncotarget, 2016-07, Vol.7 (29), p.45414-45428

2016

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Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition

Oncotarget, 2016-12, Vol.7 (50), p.83684-83700

2016

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Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement

Oncotarget, 2016-12, Vol.7 (50), p.82851-82863

2016

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Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation

Oncotarget, 2016-04, Vol.7 (17), p.23096-23105

2016

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A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia

Oncotarget, 2012-12, Vol.3 (12), p.1615-1628

2012

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Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function

Oncotarget, 2017-01, Vol.8 (5), p.8604-8621

2017

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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion

EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy

EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo

Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion

The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells

Enolase-1 is a therapeutic target in endometrial carcinoma

Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling

p85α promotes nucleolin transcription and subsequently enhances EGFR mRNA stability and EGF-induced malignant cellular transformation

The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction

Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway

Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

A beta version of life: p110β takes center stage

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit

Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition

Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement

Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia

Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function

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