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Insulin‐like growth factor‐1‐dependent maintenance of neuronal metabolism through the phosphatidylinositol 3‐kinase–Akt pathway is inhibited by C 2 ‐ceramide in CAD cells

The European journal of neuroscience, 2007-05, Vol.25 (10), p.3030-3038

2007

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Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

Medicinal research reviews, 2021-05, Vol.41 (3), p.1599-1621

2021

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Inhibition of the PI3K/AKT Pathway Reduces Tumor Necrosis Factor-Alpha Production in the Cellular Response to Wear Particles In Vitro

Artificial organs, 2013-03, Vol.37 (3), p.298-307

2013

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Targeting the Phosphatidylinositol 3‐Kinase Signaling Pathway in Breast Cancer

The oncologist (Dayton, Ohio), 2011-01, Vol.16 (4), p.404-414

2011

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E3 ubiquitin ligase casitas B-lineage lymphoma-b modulates T-cell anergic resistance via phosphoinositide 3-kinase signaling in patients with immune thrombocytopenia

Journal of thrombosis and haemostasis, 2024-04, Vol.22 (4), p.1202-1214

2024

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The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway

Phytotherapy research, 2024-01, Vol.38 (1), p.349-367

2024

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Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway

Phytotherapy research, 2019-09, Vol.33 (9), p.2298-2309

2019

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Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

International journal of cancer, 2012-04, Vol.130 (7), p.1695-1705

2012

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Siglec‐15 Regulates Osteoclast Differentiation by Modulating RANKL‐Induced Phosphatidylinositol 3‐Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

Journal of bone and mineral research, 2013-12, Vol.28 (12), p.2463-2475

2013

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Phosphoinositide 3‐kinase δ is a regulatory T‐cell target in cancer immunotherapy

Immunology, 2019-07, Vol.157 (3), p.210-218

2019

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Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells

European journal of immunology, 2020-09, Vol.50 (9), p.1386-1399

2020

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The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy

Journal of cellular biochemistry, 2017-12, Vol.118 (12), p.4163-4169

2017

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Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

FEBS letters, 2012-06, Vol.586 (11), p.1584-1591

2012

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Leptin and Neutrophil‐Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3‐Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus

Arthritis & rheumatology (Hoboken, N.J.), 2015-09, Vol.67 (9), p.2383-2393

2015

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Class 3 phosphoinositide 3‐kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity

Acta Physiologica, 2022-05, Vol.235 (1), p.e13793-n/a

2022

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An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3‐kinase

Journal of cellular biochemistry, 2021-10, Vol.122 (10), p.1326-1336

2021

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Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

Journal of cellular physiology, 2018-06, Vol.233 (6), p.4634-4642

2018

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Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies

American journal of medical genetics. Part C, Seminars in medical genetics, 2016-12, Vol.172C (4), p.402-421

2016

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The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies

Oral diseases, 2015-10, Vol.21 (7), p.815-825

2015

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Kaempferol promotes primordial follicle activation through the phosphatidylinositol 3‐kinase/protein kinase B signaling pathway and reduces DNA fragmentation of sheep preantral follicles cultured in vitro

Molecular reproduction and development, 2019-03, Vol.86 (3), p.319-329

2019

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Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition

Journal of pharmacy and pharmacology, 2022-02, Vol.74 (2), p.208-215

2022

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Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3‐kinase–protein kinase B pathway in diabetic rats

Journal of diabetes investigation, 2020-03, Vol.11 (2), p.297-306

2020

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The PI3K/Akt/mTOR axis in colorectal cancer: Oncogenic alterations, non‐coding RNAs, therapeutic opportunities, and the emerging role of nanoparticles

Journal of cellular physiology, 2022-03, Vol.237 (3), p.1720-1752

2022

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IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways

Clinical endocrinology (Oxford), 2024-03, Vol.100 (3), p.284-293

2024

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Targeting phosphatidylinositol-3-kinase for inhibiting maxillary bone resorption

Journal of cellular physiology, 2023-11, Vol.238 (11), p.2651-2667

2023

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Science & Technology
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Life Sciences & Biomedicine
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Humans
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Animals
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Cell Biology
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Signal Transduction
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Biochemistry & Molecular Biology
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Phosphatidylinositol 3-Kinases - Metabolism
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Mice
(2.443)
Male
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Proto-Oncogene Proteins C-Akt - Metabolism
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Phosphorylation
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1-Phosphatidylinositol 3-Kinase
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Journal Of Cellular Physiology
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Journal Of Neurochemistry
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Journal Of Neuroscience Research
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Journal Of Cellular And Molecular Medicine
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Insulin‐like growth factor‐1‐dependent maintenance of neuronal metabolism through the phosphatidylinositol 3‐kinase–Akt pathway is inhibited by C 2 ‐ceramide in CAD cells

Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

Inhibition of the PI3K/AKT Pathway Reduces Tumor Necrosis Factor-Alpha Production in the Cellular Response to Wear Particles In Vitro

Targeting the Phosphatidylinositol 3‐Kinase Signaling Pathway in Breast Cancer

E3 ubiquitin ligase casitas B-lineage lymphoma-b modulates T-cell anergic resistance via phosphoinositide 3-kinase signaling in patients with immune thrombocytopenia

The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway

Tanshinone IIA combined with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the phosphatidylinositol 3‐kinase/Akt signalling pathway

Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

Siglec‐15 Regulates Osteoclast Differentiation by Modulating RANKL‐Induced Phosphatidylinositol 3‐Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

Phosphoinositide 3‐kinase δ is a regulatory T‐cell target in cancer immunotherapy

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells

The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy

Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

Leptin and Neutrophil‐Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3‐Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus

Class 3 phosphoinositide 3‐kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity

An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3‐kinase

Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies

The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies

Kaempferol promotes primordial follicle activation through the phosphatidylinositol 3‐kinase/protein kinase B signaling pathway and reduces DNA fragmentation of sheep preantral follicles cultured in vitro

Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition

Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3‐kinase–protein kinase B pathway in diabetic rats

The PI3K/Akt/mTOR axis in colorectal cancer: Oncogenic alterations, non‐coding RNAs, therapeutic opportunities, and the emerging role of nanoparticles

IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways

Targeting phosphatidylinositol-3-kinase for inhibiting maxillary bone resorption

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