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Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer

Cancer letters, 2015-04, Vol.359 (1), p.47-56

2015

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Mechanisms of Autophagy Initiation

Annual review of biochemistry, 2017-06, Vol.86, p.225

2017

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Immunity (Cambridge, Mass.), 2021-05, Vol.54 (5), p.976-987.e7

2021

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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4507

2020

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Insulin Enhances Gene Expression of Midnolin , a Novel Genetic Risk Factor for Parkinson's Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells

The Journal of pharmacology and experimental therapeutics, 2022-05, Vol.381 (2), p.68

2022

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Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

Cancer discovery, 2016-08, Vol.6 (8), p.870-885

2016

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Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency

Mucosal immunology, 2019-09, Vol.12 (5), p.1187-1200

2019

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Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer

International journal of molecular sciences, 2019-07, Vol.20 (14), p.3383

2019

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The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Scientific reports, 2019-08, Vol.9 (1), p.11317-12, Article 11317

2019

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Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Nature cell biology, 2018-03, Vol.20 (3), p.307

2018

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Molecular Characterization of a B Cell Adaptor for Phosphoinositide 3-Kinase Homolog in Lamprey ( Lampetra japonica ) and Its Function in the Immune Response

International journal of molecular sciences, 2022-11, Vol.23 (22), p.14449

2022

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Class 3 phosphoinositide 3‐kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity

Acta Physiologica, 2022-05, Vol.235 (1), p.e13793-n/a

2022

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The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension

American journal of physiology. Regulatory, integrative and comparative physiology, 2022-12, Vol.323 (6), p.R861-R874

2022

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Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Scientific reports, 2022-04, Vol.12 (1), p.5924-5924, Article 5924

2022

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Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Aging (Albany, NY.), 2020-04, Vol.12 (8), p.6852-6864

2020

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Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha

International journal of molecular sciences, 2020-05, Vol.21 (10), p.3636

2020

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Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Nature communications, 2018-07, Vol.9 (1), p.2639-13, Article 2639

2018

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PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α

Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (27), p.7095-7100

2017

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Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

Gut, 2017-06, Vol.66 (6), p.1123

2017

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Bioinformatics identification of miR‐514b‐5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine‐rich tetratricopeptide repeat‐containing protein beta

The FEBS journal, 2023-02, Vol.290 (4), p.1134-1150

2023

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microRNA‐186 inhibition of PI3K–AKT pathway via SPP1 inhibits chondrocyte apoptosis in mice with osteoarthritis

Journal of cellular physiology, 2019-05, Vol.234 (5), p.6042-6053

2019

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Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway

British journal of nutrition, 2022-11, Vol.128 (10), p.1875-1886

2022

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Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1

PloS one, 2014, Vol.9 (1), p.e84964-e84964

2014

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Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression

PloS one, 2011-05, Vol.6 (5), p.e20164

2011

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Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines

Scientific reports, 2018-01, Vol.8 (1), p.1652-12, Article 1652

2018

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Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer

Mechanisms of Autophagy Initiation

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Insulin Enhances Gene Expression of Midnolin , a Novel Genetic Risk Factor for Parkinson's Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency

Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer

The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Molecular Characterization of a B Cell Adaptor for Phosphoinositide 3-Kinase Homolog in Lamprey ( Lampetra japonica ) and Its Function in the Immune Response

Class 3 phosphoinositide 3‐kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity

The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

Bioinformatics identification of miR‐514b‐5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine‐rich tetratricopeptide repeat‐containing protein beta

microRNA‐186 inhibition of PI3K–AKT pathway via SPP1 inhibits chondrocyte apoptosis in mice with osteoarthritis

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1

Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression

Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines

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