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PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8559-8581

2012

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Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

The Journal of immunology (1950), 2018-10, Vol.201 (8), p.2215-2219

2018

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Duvelisib for the treatment of chronic lymphocytic leukemia

Expert opinion on pharmacotherapy, 2020-07, Vol.21 (11), p.1299-1309

2020

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Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Science (American Association for the Advancement of Science), 2021-01, Vol.371 (6527), p.405-410

2021

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Mechanisms of Autophagy Initiation

Annual review of biochemistry, 2017-06, Vol.86, p.225

2017

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Phosphatidylinositol 3‑Kinase (PI3K) and Phosphatidylinositol 3‑Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.41-71

2015

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Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

Medicinal research reviews, 2021-05, Vol.41 (3), p.1599-1621

2021

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Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome

Annals of the rheumatic diseases, 2019-02, Vol.78 (2), p.249

2019

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Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Journal of clinical oncology, 2019-03, Vol.37 (9), p.741-750

2019

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The PI3K AKT Pathway as a Target for Cancer Treatment

Annual review of medicine, 2016-01, Vol.67 (1), p.11-28

2016

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Inhibition of the PI3K/AKT Pathway Reduces Tumor Necrosis Factor-Alpha Production in the Cellular Response to Wear Particles In Vitro

Artificial organs, 2013-03, Vol.37 (3), p.298-307

2013

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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells

The Journal of pharmacology and experimental therapeutics, 2011-04, Vol.337 (1), p.155

2011

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Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

Journal of Virology, 2013-03, Vol.87 (5), p.2508-2517

2013

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Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

The Journal of biological chemistry, 2015-07, Vol.290 (28), p.17495-17504

2015

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Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

eLife, 2014-11, Vol.3, p.e04135-e04135

2014

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4 + T Cell Proliferation

American journal of respiratory cell and molecular biology, 2017-01, Vol.56 (1), p.74-82

2017

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Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling

Clinical cancer research, 2012-08, Vol.18 (15), p.4104-4113

2012

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Antigen receptor–mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth

Blood, 2006-06, Vol.107 (11), p.4458-4465

2006

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Daily exposure to Di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice

Biology of reproduction, 2014-06, Vol.90 (6), p.136

2014

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Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Nature communications, 2024-03, Vol.15 (1), p.2612-2612

2024

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Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Proceedings of the National Academy of Sciences - PNAS, 2016-07, Vol.113 (30), p.E4338-E4347

2016

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Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Journal of neuroinflammation, 2021-11, Vol.18 (1), p.276-276, Article 276

2021

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PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Duvelisib for the treatment of chronic lymphocytic leukemia

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Mechanisms of Autophagy Initiation

Phosphatidylinositol 3‑Kinase (PI3K) and Phosphatidylinositol 3‑Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

The PI3K AKT Pathway as a Target for Cancer Treatment

Inhibition of the PI3K/AKT Pathway Reduces Tumor Necrosis Factor-Alpha Production in the Cellular Response to Wear Particles In Vitro

PI3Kγ is a molecular switch that controls immune suppression

Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4 + T Cell Proliferation

Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling

Antigen receptor–mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth

Daily exposure to Di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

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