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Concurrent Optimizations of Efficacy and Blood–Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson’s Disease Therapeutics

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7647-7662

2024

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CDK9 inhibition activates innate immune response through viral mimicry

The FASEB journal, 2024-04, Vol.38 (8), p.e23628-n/a

2024

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Out-of-phase transcranial alternating current stimulation modulates the neurodynamics of inhibitory control

NeuroImage (Orlando, Fla.), 2024-04, Vol.292, p.120612-120612, Article 120612

2024

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Expression and Purification of Recombinant Bowman–Birk Trypsin Inhibitor from Foxtail Millet Bran and Its Anticolorectal Cancer Effect In Vitro and In Vivo

Journal of agricultural and food chemistry, 2024-05, Vol.72 (18), p.10439-10450

2024

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Increased number of excitatory synapsis and decreased number of inhibitory synapsis in the prefrontal cortex in autism

Cerebral cortex (New York, N.Y. 1991), 2024-05, Vol.34 (13), p.121-128

2024

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Wighteone, a prenylated flavonoid from licorice, inhibits growth of SW480 colorectal cancer cells by allosteric inhibition of Akt

Journal of ethnopharmacology, 2024-08, Vol.330, p.118195-118195, Article 118195

2024

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Control of neuronal excitation-inhibition balance by BMP-SMAD1 signalling

Nature (London), 2024-05, Vol.629 (8011), p.402-6

2024

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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Nature (London), 2024-05, Vol.629 (8011), p.435-5

2024

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Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study

BMJ (Online), 2024-04, Vol.385, p.e078242

2024

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Hedgehog pathway inhibitors for locally advanced and metastatic basal cell carcinoma: A real-world single-center retrospective review

PloS one, 2024-04, Vol.19 (4), p.e0297531-e0297531

2024

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Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7130-7145

2024

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First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study

PloS one, 2024, Vol.19 (5), p.e0297137-e0297137

2024

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LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis

Cellular and molecular life sciences : CMLS, 2024-05, Vol.81 (1), p.206-206

2024

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Acinar to β-like cell conversion through inhibition of focal adhesion kinase

Nature communications, 2024-05, Vol.15 (1), p.3740-3740

2024

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Individualized prevention of proton pump inhibitor related adverse events by risk stratification

Nature communications, 2024-04, Vol.15 (1), p.3591-3591

2024

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LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

Nature communications, 2024-04, Vol.15 (1), p.3563-3563

2024

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Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells

European journal of pharmacology, 2024-06, Vol.973, p.176610-176610, Article 176610

2024

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Angiotensin-converting enzyme inhibition prevents l-dopa-induced dyskinesia in a 6-ohda-induced mouse model of Parkinson's disease

European journal of pharmacology, 2024-06, Vol.973, p.176573-176573, Article 176573

2024

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Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma

Nature communications, 2024-04, Vol.15 (1), p.3664-3664

2024

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Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest

Life sciences (1973), 2024-06, Vol.347, p.122682-122682, Article 122682

2024

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1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors

Bioorganic & medicinal chemistry, 2024-05, Vol.105, p.117727-117727, Article 117727

2024

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Sex-specific disparities in disease activity scores among patients with axial spondyloarthritis and their implications for evaluating the response to tumor necrosis factor alpha inhibitor therapy

Arthritis research & therapy, 2024-04, Vol.26 (1), p.90-90

2024

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IDO-1 inhibition improves outcome after fluid percussion injury in adult male rats

Journal of neuroscience research, 2024-05, Vol.102 (5), p.e25338-e25338

2024

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Downregulation of RCN1 inhibits esophageal squamous cell carcinoma progression and M2 macrophage polarization

PloS one, 2024-05, Vol.19 (5), p.e0302780-e0302780

2024

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Evidence for response inhibition as a control process distinct from the common executive function: A two-study factor analysis

Journal of experimental psychology. Learning, memory, and cognition, 2024-05

2024

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1 – 25 von 3.514

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Concurrent Optimizations of Efficacy and Blood–Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson’s Disease Therapeutics

CDK9 inhibition activates innate immune response through viral mimicry

Out-of-phase transcranial alternating current stimulation modulates the neurodynamics of inhibitory control

Expression and Purification of Recombinant Bowman–Birk Trypsin Inhibitor from Foxtail Millet Bran and Its Anticolorectal Cancer Effect In Vitro and In Vivo

Increased number of excitatory synapsis and decreased number of inhibitory synapsis in the prefrontal cortex in autism

Wighteone, a prenylated flavonoid from licorice, inhibits growth of SW480 colorectal cancer cells by allosteric inhibition of Akt

Control of neuronal excitation-inhibition balance by BMP-SMAD1 signalling

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study

Hedgehog pathway inhibitors for locally advanced and metastatic basal cell carcinoma: A real-world single-center retrospective review

Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer

First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study

LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis

Acinar to β-like cell conversion through inhibition of focal adhesion kinase

Individualized prevention of proton pump inhibitor related adverse events by risk stratification

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells

Angiotensin-converting enzyme inhibition prevents l-dopa-induced dyskinesia in a 6-ohda-induced mouse model of Parkinson's disease

Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma

Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest

1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors

Sex-specific disparities in disease activity scores among patients with axial spondyloarthritis and their implications for evaluating the response to tumor necrosis factor alpha inhibitor therapy

IDO-1 inhibition improves outcome after fluid percussion injury in adult male rats

Downregulation of RCN1 inhibits esophageal squamous cell carcinoma progression and M2 macrophage polarization

Evidence for response inhibition as a control process distinct from the common executive function: A two-study factor analysis

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