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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Cell, 2021-01, Vol.184 (2), p.404-421.e16

2021

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Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Free radical biology & medicine, 2020-05, Vol.152, p.175-185

2020

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A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning

The Journal of biological chemistry, 2020-05, Vol.295 (19), p.6357-6371

2020

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The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020-02, Vol.1865 (2), p.158550-158550, Article 158550

2020

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Calcium dysregulation in Alzheimer's disease

Neurochemistry international, 2008-03, Vol.52 (4), p.621-633

2008

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Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

The EMBO journal, 2004-02, Vol.23 (3), p.483-488

Haass, Christian

2004

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OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

Cellular and molecular life sciences : CMLS, 2014-07, Vol.71 (13), p.2561-2576

2014

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Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin

The Journal of biological chemistry, 2003-09, Vol.278 (39), p.37213-37222

2003

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Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane

Biochemical and biophysical research communications, 2018-03, Vol.498 (2), p.334-341

2018

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Aph-1 Contributes to the Stabilization and Trafficking of the γ-Secretase Complex through Mechanisms Involving Intermolecular and Intramolecular Interactions

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.12967-12975

2005

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Novel genomic signals of recent selection in an Ethiopian population

European journal of human genetics : EJHG, 2015-08, Vol.23 (8), p.1085-1092

2015

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Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

The Journal of biological chemistry, 2010-08, Vol.285 (34), p.26174-26181

2010

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A Nine-transmembrane Domain Topology for Presenilin 1

The Journal of biological chemistry, 2005-10, Vol.280 (42), p.35352-35360

2005

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

The Journal of biological chemistry, 2003-07, Vol.278 (29), p.26687-26694

2003

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Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

International Journal of Biochemistry and Cell Biology, 2003-11, Vol.35 (11), p.1505-1535

2003

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Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

The Journal of biological chemistry, 2005-04, Vol.280 (17), p.17020-17026

2005

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Recombinant protein expression in Pichia pastoris

Molecular biotechnology, 2000-09, Vol.16 (1), p.23-52

2000

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Simulating the γ-secretase enzyme: Recent advances and future directions

Biochimie, 2018-04, Vol.147, p.130-135

2018

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Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging

The Journal of biological chemistry, 2006-02, Vol.281 (5), p.2405-2413

2006

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γ-Secretase Exists on the Plasma Membrane as an Intact Complex That Accepts Substrates and Effects Intramembrane Cleavage

The Journal of biological chemistry, 2005-02, Vol.280 (6), p.4383-4392

2005

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S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

The Journal of biological chemistry, 2009-01, Vol.284 (3), p.1373-1384

2009

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Pen-2 Is Sequestered in the Endoplasmic Reticulum and Subjected to Ubiquitylation and Proteasome-mediated Degradation in the Absence of Presenilin

The Journal of biological chemistry, 2004-04, Vol.279 (16), p.16744-16753

2004

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Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody

FEBS open bio, 2021-03, Vol.11 (3), p.813-825

2021

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The Transmembrane Domain Region of Nicastrin Mediates Direct Interactions with APH-1 and the γ-Secretase Complex

The Journal of biological chemistry, 2003-10, Vol.278 (44), p.43284-43291

2003

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Lack of p53 induction in fish cells by model chemotherapeutics

Oncogene, 2006-03, Vol.25 (14), p.2004-2010

2006

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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning

The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew

Calcium dysregulation in Alzheimer's disease

Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin

Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin

Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane

Aph-1 Contributes to the Stabilization and Trafficking of the γ-Secretase Complex through Mechanisms Involving Intermolecular and Intramolecular Interactions

Novel genomic signals of recent selection in an Ethiopian population

Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

A Nine-transmembrane Domain Topology for Presenilin 1

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

Recombinant protein expression in Pichia pastoris

Simulating the γ-secretase enzyme: Recent advances and future directions

Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging

γ-Secretase Exists on the Plasma Membrane as an Intact Complex That Accepts Substrates and Effects Intramembrane Cleavage

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

Pen-2 Is Sequestered in the Endoplasmic Reticulum and Subjected to Ubiquitylation and Proteasome-mediated Degradation in the Absence of Presenilin

Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody

The Transmembrane Domain Region of Nicastrin Mediates Direct Interactions with APH-1 and the γ-Secretase Complex

Lack of p53 induction in fish cells by model chemotherapeutics

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