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Activation of Viruses by Host Proteases

1st ed. 2018., 2018

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TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice

Journal of virology, 2014-05, Vol.88 (9), p.4744-4751

2014

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Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

Vaccine, 2012-12, Vol.30 (51), p.7374-7380

2012

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Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells

Antiviral research, 2015-08, Vol.120, p.89-100

2015

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The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation

Current opinion in virology, 2023-02, Vol.58, p.101303-101303, Article 101303

2023

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ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells

Journal of virology, 2024-03, Vol.98 (4), p.e0010224

2024

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Mechanisms of hemagglutinin targeted influenza virus neutralization

PloS one, 2013-12, Vol.8 (12), p.e80034-e80034

2013

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Receptor-binding properties of influenza viruses isolated from gulls

Virology (New York, N.Y.), 2018-09, Vol.522, p.37-45

2018

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Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinase

Virology (New York, N.Y.), 2015-08, Vol.482, p.1-8

2015

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Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion

Viruses, 2012-07, Vol.4 (7), p.1144-1168

2012

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Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses

Virology (New York, N.Y.), 2019-09, Vol.535, p.232-240

2019

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Adaptive amino acid substitutions enhance the virulence of a reassortant H7N1 avian influenza virus isolated from wild waterfowl in mice

Virology (New York, N.Y.), 2015-02, Vol.476, p.233-239

2015

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Unveiling the role of host kinases at different steps of influenza A virus life cycle

Journal of virology, 2024-01, Vol.98 (1), p.e0119223

2024

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Virus-Bacteria Interactions: An Emerging Topic in Human Infection

Viruses, 2017-03, Vol.9 (3), p.58

2017

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Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape

Virology (New York, N.Y.), 2018-01, Vol.513, p.29-42

2018

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Development of an in vitro model for animal species susceptibility to SARS-CoV-2 replication based on expression of ACE2 and TMPRSS2 in avian cells

Virology (New York, N.Y.), 2022-04, Vol.569, p.1-12

2022

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Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice

Virology journal, 2023-04, Vol.20 (1), p.78-78, Article 78

2023

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Proteolytic enzymes in embryonated chicken eggs sustain the replication of egg-grown low-pathogenicity avian influenza viruses in cells in the absence of exogenous proteases

Journal of virological methods, 2014-06, Vol.202, p.28-33

2014

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The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression

Journal of virology, 2021-05, Vol.95 (11)

2021

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Complex N -glycans are important for interspecies transmission of H7 influenza A viruses

Journal of virology, 2024-03, Vol.98 (4), p.e0194123

2024

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Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins

PloS one, 2019-04, Vol.14 (4), p.e0214968-e0214968

2019

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Current status on the development of pseudoviruses for enveloped viruses

Reviews in medical virology, 2018-01, Vol.28 (1), p.n/a

2018

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Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics

Virology journal, 2021-07, Vol.18 (1), p.154-154, Article 154

2021

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Recent Advances on Targeting Proteases for Antiviral Development

Viruses, 2024-02, Vol.16 (3), p.366

2024

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Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools

Virus research, 2011-09, Vol.160 (1-2), p.294-304

2011

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Activation of Viruses by Host Proteases

TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells

The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation

ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells

Mechanisms of hemagglutinin targeted influenza virus neutralization

Receptor-binding properties of influenza viruses isolated from gulls

Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinase

Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion

Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses

Adaptive amino acid substitutions enhance the virulence of a reassortant H7N1 avian influenza virus isolated from wild waterfowl in mice

Unveiling the role of host kinases at different steps of influenza A virus life cycle

Virus-Bacteria Interactions: An Emerging Topic in Human Infection

Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape

Development of an in vitro model for animal species susceptibility to SARS-CoV-2 replication based on expression of ACE2 and TMPRSS2 in avian cells

Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice

Proteolytic enzymes in embryonated chicken eggs sustain the replication of egg-grown low-pathogenicity avian influenza viruses in cells in the absence of exogenous proteases

The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression

Complex N -glycans are important for interspecies transmission of H7 influenza A viruses

Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins

Current status on the development of pseudoviruses for enveloped viruses

Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics

Recent Advances on Targeting Proteases for Antiviral Development

Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools

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