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Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium

Pathogens and disease, 2013-11, Vol.69 (2), p.87-100

2013

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Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

Journal of Virology, 2011-02, Vol.85 (4), p.1554-1562

2011

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Activation of Influenza A Viruses by Host Proteases from Swine Airway Epithelium

Journal of Virology, 2014-01, Vol.88 (1), p.282-291

2014

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Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

Journal of Virology, 2010-06, Vol.84 (11), p.5605-5614

2010

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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

Life science alliance, 2020-09, Vol.3 (9), p.e202000786

2020

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TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

Journal of virology, 2019-11, Vol.93 (21)

2019

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Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors

ChemMedChem, 2024-05, Vol.19 (9), p.e202400057-e202400057

2024

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Structural characterization and bioactivity profiling of the fungal peptaibiotic tolypin reveal protective effects against influenza viruses

Archiv der Pharmazie (Weinheim), 2024-07, p.e2400384

2024

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Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

Journal of Virology, 2013-02, Vol.87 (3), p.1811-1820

2013

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MSC Based Therapies-New Perspectives for the Injured Lung

Journal of clinical medicine, 2020-03, Vol.9 (3), p.682

2020

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TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice

Journal of virology, 2014-05, Vol.88 (9), p.4744-4751

2014

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The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

ACS medicinal chemistry letters, 2021-03, Vol.12 (3), p.426-432

2021

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Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

Vaccine, 2012-12, Vol.30 (51), p.7374-7380

2012

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The hemagglutinin: a determinant of pathogenicity

Current topics in microbiology and immunology, 2014, Vol.385, p.3

2014

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Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage

Virus research, 2024-09, Vol.347, p.199430, Article 199430

2024

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Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells

Antiviral research, 2015-08, Vol.120, p.89-100

2015

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Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

European journal of cell biology, 2015-07, Vol.94 (7-9), p.375-383

2015

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TRAIL protects the immature lung from hyperoxic injury

Cell death & disease, 2022-07, Vol.13 (7), p.614-10, Article 614

2022

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The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation

Current opinion in virology, 2023-02, Vol.58, p.101303-101303, Article 101303

2023

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Insertion of Basic Amino Acids in the Hemagglutinin Cleavage Site of H4N2 Avian Influenza Virus (AIV)-Reduced Virus Fitness in Chickens is Restored by Reassortment with Highly Pathogenic H5N1 AIV

International journal of molecular sciences, 2020-03, Vol.21 (7), p.2353

2020

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Optimization of Substrate‐Analogue Furin Inhibitors

ChemMedChem, 2017-12, Vol.12 (23), p.1953-1968

2017

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The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo

Virulence, 2021-12, Vol.12 (1), p.666-678

2021

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Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4860-4864

2011

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SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Cell, 2021-04, Vol.184 (9), p.2384-2393.e12

2021

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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Cell, 2020-05, Vol.181 (5), p.1016-1035.e19

2020

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Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium

Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

Activation of Influenza A Viruses by Host Proteases from Swine Airway Epithelium

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors

Structural characterization and bioactivity profiling of the fungal peptaibiotic tolypin reveal protective effects against influenza viruses

Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

MSC Based Therapies-New Perspectives for the Injured Lung

TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

The hemagglutinin: a determinant of pathogenicity

Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage

Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

TRAIL protects the immature lung from hyperoxic injury

The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation

Insertion of Basic Amino Acids in the Hemagglutinin Cleavage Site of H4N2 Avian Influenza Virus (AIV)-Reduced Virus Fitness in Chickens is Restored by Reassortment with Highly Pathogenic H5N1 AIV

Optimization of Substrate‐Analogue Furin Inhibitors

The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

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