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Disposition and metabolism of [14C]lemborexant, a novel dual orexin receptor antagonist, in rats and monkeys

Xenobiotica, 2019-06, Vol.49 (6), p.688-697

2019

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Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects

Xenobiotica, 2022-08, Vol.52 (8), p.878-889

2022

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Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

Xenobiotica, 2016-11, Vol.46 (11), p.986-1000

2016

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Disposition of [14C]LY2606368 following intravenous administration in patients with advanced and/or metastatic solid tumours

Xenobiotica, 2020-07, Vol.50 (7), p.793-804

2020

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Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats

Xenobiotica, 2019-04, Vol.49 (4), p.463-473

2019

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Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection

Xenobiotica, 2022-11, Vol.52 (9-11), p.973-985

2022

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Disposition, metabolism and mass balance of [14C]apremilast following oral administration

Xenobiotica, 2011-12, Vol.41 (12), p.1063-1075

2011

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Disposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison

Xenobiotica, 2018-11, Vol.48 (11), p.1128-1141

2018

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Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats

Xenobiotica, 2014-11, Vol.44 (11), p.996-1008

2014

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Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats

Xenobiotica, 2015-08, Vol.45 (8), p.711-721

2015

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Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition

Xenobiotica, 2018-05, Vol.48 (5), p.442-451

2018

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Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline

Xenobiotica, 2017-08, Vol.47 (8), p.682-696

2017

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Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

mAbs, 2015-09, Vol.7 (5), p.881-890

2015

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Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

Xenobiotica, 2008-08, Vol.38 (7-8), p.802-832

Zhou, S.-F.

2008

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In vitro assessment of the roles of drug transporters in the disposition and drug-drug interaction potential of olaparib

Xenobiotica, 2017-10, Vol.47 (10), p.903-915

2017

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Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration

Xenobiotica, 2020-10, Vol.50 (10), p.1236-1241

2020

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Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition

Xenobiotica, 2020-03, Vol.50 (3), p.245-251

2020

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Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

mAbs, 2021-01, Vol.13 (1), p.1993769-1993769

2021

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Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics

Xenobiotica, 2018-04, Vol.48 (4), p.382-399

2018

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The metabolism and disposition of GSK2140944 in healthy human subjects

Xenobiotica, 2016-08, Vol.46 (8), p.683-702

2016

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Disposition and metabolism of [14C]PTZ601 in healthy volunteers

Xenobiotica, 2013-03, Vol.43 (3), p.283-292

2013

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Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans

Xenobiotica, 2019-07, Vol.49 (7), p.811-822

2019

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Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells

Xenobiotica, 2020-08, Vol.50 (8), p.997-1008

2020

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Metabolism and disposition of a potent and selective JNK inhibitor [14C]tanzisertib following oral administration to rats, dogs and humans

Xenobiotica, 2015-05, Vol.45 (5), p.428-441

2015

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Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans

Xenobiotica, 2020-05, Vol.50 (5), p.559-569

2020

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Disposition and metabolism of [14C]lemborexant, a novel dual orexin receptor antagonist, in rats and monkeys

Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects

Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

Disposition of [14C]LY2606368 following intravenous administration in patients with advanced and/or metastatic solid tumours

Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats

Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection

Disposition, metabolism and mass balance of [14C]apremilast following oral administration

Disposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison

Metabolism and disposition of [14C]tivantinib after oral administration to humans, dogs and rats

Metabolic disposition of the anti-cancer agent [14C]laromustine in male rats

Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

In vitro assessment of the roles of drug transporters in the disposition and drug-drug interaction potential of olaparib

Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration

Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition

Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics

The metabolism and disposition of GSK2140944 in healthy human subjects

Disposition and metabolism of [14C]PTZ601 in healthy volunteers

Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans

Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells

Metabolism and disposition of a potent and selective JNK inhibitor [14C]tanzisertib following oral administration to rats, dogs and humans

Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans

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