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Review and Current Perspectives on DNA Topoisomerase I and II Enzymes of Fungi as Study Models for the Development of New Antifungal Drugs

Journal of fungi (Basel), 2024-09, Vol.10 (9), p.629

2024

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Design, synthesis and in vitro cytotoxic evaluation of β-carboline tethered quinoline-4-carboxamide conjugates as DNA-interactive Topo II inhibitors

Journal of molecular structure, 2023-11, Vol.1291, p.136001, Article 136001

2023

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Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity

European journal of medicinal chemistry, 2017-06, Vol.133, p.69-84

2017

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Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide

Biochimica et biophysica acta. Gene regulatory mechanisms, 2017-05, Vol.1860 (5), p.617-629

2017

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Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIα expression in oral carcinoma

Head & neck, 2007-11, Vol.29 (11), p.1002-1009

2007

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Design, synthesis, cytotoxicity evaluation and molecular docking studies of 1,4-naphthoquinone derivatives

Journal of molecular structure, 2022-09, Vol.1263, p.133067, Article 133067

2022

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A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition

Journal of biomolecular structure & dynamics, 2024-03, p.1-19

2024

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Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.299-314

2022

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Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae

Genetics (Austin), 2020-05, Vol.215 (1), p.59-73

2020

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Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction

Bioorganic chemistry, 2024-04, Vol.145, p.107223-107223, Article 107223

2024

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A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone

Current medicinal chemistry, 2016-02, Vol.23 (6), p.520-577

2016

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Synthesis, anticancer evaluation, and molecular docking study of novel 4‐hydroxybenzo[h][1,6]naphthyridine‐2,5‐dione derivatives

Journal of physical organic chemistry, 2023-02, Vol.36 (2), p.n/a

Mostafa, Mai A.

2023

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Development of β-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIα inhibition and apoptosis induction

Bioorganic chemistry, 2021-01, Vol.106, p.104481-104481, Article 104481

2021

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Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2166037-2166037

2023

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Carbazole derivatives containing chalcone analogues targeting topoisomerase II inhibition: First principles characterization and QSAR modelling

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2020-12, Vol.242, p.118724, Article 118724

2020

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Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison

European journal of medicinal chemistry, 2021-12, Vol.226, p.113860, Article 113860

2021

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Pharmacophore‐based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators

Archiv der Pharmazie (Weinheim), 2024-09, Vol.357 (9), p.e2400217-n/a

2024

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Expression and functional analysis of various structural domains of tobacco topoisomerase II: To understand the mechanistic insights of plant type II topoisomerases

Plant physiology and biochemistry, 2023-01, Vol.194, p.302-314

2023

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Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.1556-1567

2022

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Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity

Bioorganic chemistry, 2020-12, Vol.105, p.104357-104357, Article 104357

2020

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Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies

Bioorganic chemistry, 2023-02, Vol.131, p.106313, Article 106313

2023

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Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy

Molecules (Basel, Switzerland), 2022-08, Vol.27 (17), p.5561

2022

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Human topoisomerase IIα nuclear export is mediated by two CRM-1-dependent nuclear export signals

Journal of cell science, 2004-06, Vol.117 (14), p.3061-3071

2004

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Mechanisms regulating resistance to inhibitors of topoisomerase II

Frontiers in pharmacology, 2013-01, Vol.4, p.89

2013

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Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4′-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors

Bioorganic & medicinal chemistry letters, 2018-01, Vol.28 (2), p.71-76

2018

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Review and Current Perspectives on DNA Topoisomerase I and II Enzymes of Fungi as Study Models for the Development of New Antifungal Drugs

Design, synthesis and in vitro cytotoxic evaluation of β-carboline tethered quinoline-4-carboxamide conjugates as DNA-interactive Topo II inhibitors

Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity

Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide

Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIα expression in oral carcinoma

Design, synthesis, cytotoxicity evaluation and molecular docking studies of 1,4-naphthoquinone derivatives

A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition

Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies

Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae

Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction

A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone

Synthesis, anticancer evaluation, and molecular docking study of novel 4‐hydroxybenzo[h][1,6]naphthyridine‐2,5‐dione derivatives

Development of β-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIα inhibition and apoptosis induction

Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies

Carbazole derivatives containing chalcone analogues targeting topoisomerase II inhibition: First principles characterization and QSAR modelling

Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison

Pharmacophore‐based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators

Expression and functional analysis of various structural domains of tobacco topoisomerase II: To understand the mechanistic insights of plant type II topoisomerases

Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity

Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies

Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy

Human topoisomerase IIα nuclear export is mediated by two CRM-1-dependent nuclear export signals

Mechanisms regulating resistance to inhibitors of topoisomerase II

Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4′-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors

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