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Targeting PI3K/Akt/mTOR Signaling in Cancer

Frontiers in oncology, 2014-01, Vol.4, p.64-64

2014

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Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly Polymeric Micelles

International journal of nanomedicine, 2021-07, Vol.16, p.4873

2021

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PECAM-1 mediates temsirolimus-induced increase in neutrophil transendothelial migration that leads to lung injury

Biochemical and biophysical research communications, 2023-11, Vol.682, p.180-186

2023

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Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-18

2018

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Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Nature medicine, 2019-04, Vol.25 (4), p.620-627

2019

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Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

Gene, 2015-12, Vol.574 (2), p.193-203

2015

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Transcriptomic Analysis of the Effect of Torin-2 on the Central Nervous System of IDrosophila melanogaster/I

International journal of molecular sciences, 2023-05, Vol.24 (10)

2023

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A phase II study of frontline paclitaxel/carboplatin/bevacizumab, paclitaxel/carboplatin/temsirolimus, or ixabepilone/carboplatin/bevacizumab in advanced/recurrent endometrial cancer

Gynecologic oncology, 2018-08, Vol.150 (2), p.274-281

2018

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Safety and efficacy of temsirolimus in combination with three different immuno-chemotherapy regimens in relapse and refractory mantle cell lymphoma, final results of the T phase IB trial of the LYSA

Annals of hematology, 2020-08, Vol.99 (8), p.1771-1778

2020

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Rendezvous with PI(3,5)P2 — A rapalog gets caught opening TRPML1

Cell calcium (Edinburgh), 2022-07, Vol.105, p.102597-102597, Article 102597

2022

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Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

International journal of nanomedicine, 2019-09, Vol.14, p.7643-7663

2019

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Autophagy as a molecular target for cancer treatment

European journal of pharmaceutical sciences, 2019-06, Vol.134, p.116-137

2019

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Phase I Study of Docetaxel and Temsirolimus in Refractory Solid Tumors

American journal of clinical oncology, 2021-09, Vol.44 (9), p.443-448

2021

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Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance

The oncologist (Dayton, Ohio), 2021-04, Vol.26 (4), p.e608-e621

2021

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Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)

Gynecologic oncology, 2013-08, Vol.130 (2), p.269-274

2013

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Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer

Pharmacological research, 2019-11, Vol.149, p.104352-104352, Article 104352

2019

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Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL)

Leukemia, 2019-04, Vol.33 (4), p.844-862

2019

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A phase II study of bevacizumab and temsirolimus in advanced extra-pancreatic neuroendocrine tumors

Endocrine-related cancer, 2023-11, Vol.30 (11), p.1

2023

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Temsirolimus as a dual inhibitor of retinoblastoma and angiogenesis via targeting mTOR signalling

Biochemical and biophysical research communications, 2019-08, Vol.516 (3), p.726-732

2019

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Effects of Target of Rapamycin and Phosphatidylinositol 3-Kinase Inhibitors and Other Autophagy-Related Supplements on Life Span in y w Male Drosophila melanogaster

International journal of molecular sciences, 2024-11, Vol.25 (21), p.11504

2024

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PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?

Geburtshilfe und Frauenheilkunde, 2017-10, Vol.77 (10), p.1095-1103

2017

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Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer

Pharmacological research, 2019-09, Vol.147, p.104396-104396, Article 104396

2019

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A phase II evaluation of temsirolimus with carboplatin and paclitaxel followed by temsirolimus consolidation in clear cell ovarian cancer: An NRG oncology trial

Gynecologic oncology, 2022-12, Vol.167 (3), p.423-428

2022

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Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Aging cell, 2016-02, Vol.15 (1), p.28-38

2016

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Dual suppression of follicle activation pathways completely prevents the cyclophosphamide-induced loss of ovarian reserve

Human reproduction (Oxford), 2023-06, Vol.38 (6), p.1086-1098

2023

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Targeting PI3K/Akt/mTOR Signaling in Cancer

Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly Polymeric Micelles

PECAM-1 mediates temsirolimus-induced increase in neutrophil transendothelial migration that leads to lung injury

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

Transcriptomic Analysis of the Effect of Torin-2 on the Central Nervous System of IDrosophila melanogaster/I

A phase II study of frontline paclitaxel/carboplatin/bevacizumab, paclitaxel/carboplatin/temsirolimus, or ixabepilone/carboplatin/bevacizumab in advanced/recurrent endometrial cancer

Safety and efficacy of temsirolimus in combination with three different immuno-chemotherapy regimens in relapse and refractory mantle cell lymphoma, final results of the T phase IB trial of the LYSA

Rendezvous with PI(3,5)P2 — A rapalog gets caught opening TRPML1

Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

Autophagy as a molecular target for cancer treatment

Phase I Study of Docetaxel and Temsirolimus in Refractory Solid Tumors

Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance

Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)

Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer

Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL)

A phase II study of bevacizumab and temsirolimus in advanced extra-pancreatic neuroendocrine tumors

Temsirolimus as a dual inhibitor of retinoblastoma and angiogenesis via targeting mTOR signalling

Effects of Target of Rapamycin and Phosphatidylinositol 3-Kinase Inhibitors and Other Autophagy-Related Supplements on Life Span in y w Male Drosophila melanogaster

PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?

Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer

A phase II evaluation of temsirolimus with carboplatin and paclitaxel followed by temsirolimus consolidation in clear cell ovarian cancer: An NRG oncology trial

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Dual suppression of follicle activation pathways completely prevents the cyclophosphamide-induced loss of ovarian reserve

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