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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Cell reports (Cambridge), 2024-05, Vol.43 (5), p.114134-114134, Article 114134

2024

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Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Cell chemical biology, 2019-11, Vol.26 (11), p.1586-1593.e3

2019

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Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A

Cell chemical biology, 2021-04, Vol.28 (4), p.475-486.e8

2021

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Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition

Chemistry : a European journal, 2016-08, Vol.22 (34), p.12006-12010

2016

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The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo

Antiviral research, 2021-02, Vol.186, p.105012-105012, Article 105012

2021

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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

Cell reports (Cambridge), 2021-10, Vol.37 (2), p.109806-109806, Article 109806

2021

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Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris

mBio, 2020-03, Vol.11 (2)

2020

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A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues

Bioorganic & medicinal chemistry, 2017-12, Vol.25 (23), p.6197-6202

2017

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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Cell reports (Cambridge), 2020-02, Vol.30 (8), p.2481-2488.e5

2020

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Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol

Antiviral research, 2020-03, Vol.175, p.104706-104706, Article 104706

2020

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CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

Cell reports (Cambridge), 2016-06, Vol.15 (11), p.2340-2347

2016

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Exploring the targeting spectrum of rocaglates among eIF4A homologs

RNA (Cambridge), 2023-06, Vol.29 (6), p.826-835

2023

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Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

Planta medica, 2021-10, Vol.87 (12/13), p.937-948

2021

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Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells

Journal of cellular and molecular medicine, 2020-06, Vol.24 (12), p.6988-6999

2020

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Potent anti-coronaviral activity of pateamines and new insights into their mode of action

Heliyon, 2024-07, Vol.10 (13), p.e33409, Article e33409

2024

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Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication

Antiviral research, 2022-08, Vol.204, p.105359-105359, Article 105359

2022

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Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from Aglaia species (Meliaceae)

Phytochemistry reviews, 2022-06, Vol.21 (3), p.725-764

Greger, Harald

2022

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Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System

International journal of molecular sciences, 2023-03, Vol.24 (6), p.5872

2023

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Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates-A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics

Microorganisms (Basel), 2021-03, Vol.9 (3), p.540

2021

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Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.262-264

2016

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In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol

Pharmaceuticals (Basel, Switzerland), 2022-08, Vol.15 (9), p.1086

2022

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A Cytotoxic Rocaglate Compound from The Stembark of Aglaia argentea (Meliaceae)

Molekul (Purwokerto), 2017-11, Vol.12 (2), p.146-152

2017

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Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Viruses, 2022-03, Vol.14 (3), p.519

2022

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Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

Cells (Basel, Switzerland), 2021-02, Vol.10 (2), p.301

2021

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A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

EBioMedicine, 2015-11, Vol.2 (11), p.1600-1606

2015

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition

The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris

A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

Exploring the targeting spectrum of rocaglates among eIF4A homologs

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells

Potent anti-coronaviral activity of pateamines and new insights into their mode of action

Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication

Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from Aglaia species (Meliaceae)

Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System

Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates-A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics

Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II

In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol

A Cytotoxic Rocaglate Compound from The Stembark of Aglaia argentea (Meliaceae)

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

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