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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4908-4927

2015

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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature communications, 2021-02, Vol.12 (1), p.1176-1176, Article 1176

2021

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Nature (London), 2013-04, Vol.496 (7443), p.101-105

2013

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KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Cancer cell, 2012-01, Vol.21 (1), p.105-120

2012

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KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

Cell, 2014-07, Vol.158 (1), p.171-184

2014

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Ras protein abundance correlates with Ras isoform mutation patterns in cancer

Oncogene, 2023-04, Vol.42 (15), p.1224-1232

2023

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Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Nature communications, 2020-11, Vol.11 (1), p.6049-14, Article 6049

2020

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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

Nature communications, 2017-05, Vol.8 (1), p.15090-15090, Article 15090

2017

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention

Cancer discovery, 2022-04, Vol.12 (4), p.913-923

2022

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mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

Oncogene, 2015-11, Vol.34 (45), p.5607-5616

2015

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Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response

Cancer cell, 2014-02, Vol.25 (2), p.243-256

2014

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Combinatorial strategies to target RAS-driven cancers

Nature reviews. Cancer, 2024-05, Vol.24 (5), p.316-337

2024

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Capturing RAS oligomerization on a membrane

Proceedings of the National Academy of Sciences - PNAS, 2024-08, Vol.121 (34), p.e2405986121

2024

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The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

Cell, 2012-04, Vol.149 (3), p.642-655

2012

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Ras and exosome signaling

Seminars in cancer biology, 2019-02, Vol.54, p.131-137

2019

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Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma

Cancer cell, 2013-11, Vol.24 (5), p.603-616

2013

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Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Cancer research (Chicago, Ill.), 2023-10, Vol.83 (19), p.3176-3183

2023

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Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

Nature structural & molecular biology, 2022-10, Vol.29 (10), p.966-977

2022

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Crystallographic Studies of KRAS in Complex with Small Molecules and RAS-Binding Proteins

Methods in molecular biology (Clifton, N.J.), 2024, Vol.2797, p.47

2024

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RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Biochemical journal, 2020-08, Vol.477 (15), p.2893-2919

2020

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Mechanisms of isoform-specific residue influence on GTP-bound HRas, KRas, and NRas

Biophysical journal, 2022-10, Vol.121 (19), p.3616-3629

2022

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Finding the sweet spot: Targeting RAS in tumors while sparing normal tissue

Cancer cell, 2024-06, Vol.42 (6), p.943-945

2024

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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

Ras protein abundance correlates with Ras isoform mutation patterns in cancer

Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention

mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response

Combinatorial strategies to target RAS-driven cancers

Capturing RAS oligomerization on a membrane

The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

Ras and exosome signaling

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

Crystallographic Studies of KRAS in Complex with Small Molecules and RAS-Binding Proteins

RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Mechanisms of isoform-specific residue influence on GTP-bound HRas, KRas, and NRas

Finding the sweet spot: Targeting RAS in tumors while sparing normal tissue

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