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Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency

Frontiers in immunology, 2021-09, Vol.12, p.724991-724991

2021

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Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila

The Journal of experimental medicine, 2010-08, Vol.207 (8), p.1713-1726

2010

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Regulatory properties of statins and rho gtpases prenylation inhibitiors to stimulate melanoma immunogenicity and promote anti‐melanoma immune response

International journal of cancer, 2017-02, Vol.140 (4), p.747-755

2017

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Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis

The Journal of biological chemistry, 2012-01, Vol.287 (5), p.3301-3312

2012

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Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease

Molecular neurobiology, 2014-08, Vol.50 (1), p.177-185

2014

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The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure

The Journal of pathology, 2015-04, Vol.235 (5), p.672-685

2015

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In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway

Pharmacological research, 2021-05, Vol.167, p.105528-105528, Article 105528

2021

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Lovastatin Enhances Clearance of Apoptotic Cells (Efferocytosis) with Implications for Chronic Obstructive Pulmonary Disease

Journal of Immunology, 2006-06, Vol.176 (12), p.7657-7665

2006

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Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo

Journal of genetics and genomics, 2021-04, Vol.48 (4), p.300-311

2021

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Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

Proceedings of the National Academy of Sciences - PNAS, 2005-10, Vol.102 (40), p.14416-14421

2005

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Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice

Acta neuropathologica communications, 2021-07, Vol.9 (1), p.129-129, Article 129

2021

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Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells

Haematologica (Roma), 2013-01, Vol.98 (1), p.31-40

2013

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Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (12), p.4997-5002

2011

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Towards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiae

PloS one, 2015-03, Vol.10 (3), p.e0120716-e0120716

2015

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Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies

Reproductive toxicology (Elmsford, N.Y.), 2014-07, Vol.46, p.115-120

2014

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Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy

Cancer cell, 2005-04, Vol.7 (4), p.297-300

Sebti, Saïd M.

2005

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β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage

The Journal of neuroscience, 2012-05, Vol.32 (19), p.6490-6500

2012

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Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

Cell metabolism, 2020-12, Vol.32 (6), p.996-1011.e7

2020

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RhoGDI facilitates geranylgeranyltransferase-I-mediated RhoA prenylation

Biochemical and biophysical research communications, 2014-10, Vol.452 (4), p.967-973

2014

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Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease

Biomedicine & pharmacotherapy, 2017-12, Vol.96, p.489-496

2017

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Soluble Guanylate Cyclases Act in Neurons Exposed to the Body Fluid to Promote C. elegans Aggregation Behavior

Current biology, 2004-06, Vol.14 (12), p.1105-1111

2004

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RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (21), p.8862-8866

2011

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Efficient Use of Exogenous Isoprenols for Protein Isoprenylation by MDA-MB-231 Cells Is Regulated Independently of the Mevalonate Pathway

The Journal of biological chemistry, 2013-09, Vol.288 (38), p.27444-27455

2013

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The Farnesyl-diphosphate/Geranylgeranyl-diphosphate Synthase of Toxoplasma gondii Is a Bifunctional Enzyme and a Molecular Target of Bisphosphonates

The Journal of biological chemistry, 2007-10, Vol.282 (42), p.30804-30816

2007

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Role of protein farnesylation events in the ABA-mediated regulation of the Pinoresinol–Lariciresinol Reductase 1 (LuPLR1) gene expression and lignan biosynthesis in flax (Linum usitatissimum L.)

Plant physiology and biochemistry, 2013-11, Vol.72, p.96-111

2013

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Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila

Regulatory properties of statins and rho gtpases prenylation inhibitiors to stimulate melanoma immunogenicity and promote anti‐melanoma immune response

Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis

Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease

The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure

In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway

Lovastatin Enhances Clearance of Apoptotic Cells (Efferocytosis) with Implications for Chronic Obstructive Pulmonary Disease

Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice

Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

Towards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiae

Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies

Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy

β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

RhoGDI facilitates geranylgeranyltransferase-I-mediated RhoA prenylation

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease

Soluble Guanylate Cyclases Act in Neurons Exposed to the Body Fluid to Promote C. elegans Aggregation Behavior

RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments

Efficient Use of Exogenous Isoprenols for Protein Isoprenylation by MDA-MB-231 Cells Is Regulated Independently of the Mevalonate Pathway

The Farnesyl-diphosphate/Geranylgeranyl-diphosphate Synthase of Toxoplasma gondii Is a Bifunctional Enzyme and a Molecular Target of Bisphosphonates

Role of protein farnesylation events in the ABA-mediated regulation of the Pinoresinol–Lariciresinol Reductase 1 (LuPLR1) gene expression and lignan biosynthesis in flax (Linum usitatissimum L.)

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