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R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe-3-Hydroxypipecolic Acid

Molecules (Basel, Switzerland), 2023-02, Vol.28 (4)

2023

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Screening a knowledge‐based library of low molecular weight compounds against the proline biosynthetic enzyme 1‐pyrroline‐5‐carboxylate 1 (PYCR1)

Protein science, 2024-07, Vol.33 (7), p.e5072-n/a

2024

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Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Nature communications, 2017-07, Vol.8 (1), p.16031-16031, Article 16031

2017

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Structures of l‐proline trans‐hydroxylase reveal the catalytic specificity and provide deeper insight into AKG‐dependent hydroxylation

Acta crystallographica. Section D, Biological crystallography., 2023-04, Vol.79 (4), p.318-325

2023

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Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy

Amino acids, 2021-12, Vol.53 (12), p.1917-1925

2021

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Structure, function, and mechanism of proline utilization A (PutA)

Archives of biochemistry and biophysics, 2017-10, Vol.632, p.142-157

2017

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Structural Biology of Proline Catabolic Enzymes

Antioxidants & redox signaling, 2019-02, Vol.30 (4), p.650-673

Tanner, John J

2019

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Discovery and quantification of bioactive peptides in fermented cucumber by direct analysis IR-MALDESI mass spectrometry and LC-QQQ-MS

Food chemistry, 2019-01, Vol.271, p.715-723

2019

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Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Nature communications, 2018-10, Vol.9 (1), p.4456-16, Article 4456

2018

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Proline metabolism in cancer

Amino acids, 2021-12, Vol.53 (12), p.1769-1777

2021

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Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target

Amino acids, 2021-12, Vol.53 (12), p.1817-1834

2021

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N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties

Amino acids, 2021-12, Vol.53 (12), p.1927-1939

2021

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Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

Antioxidants & redox signaling, 2019-02, Vol.30 (4), p.635-649

Phang, James M

2019

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Pyrroline‐5‐carboxylate dehydrogenase is an essential enzyme for proline dehydrogenase function during dark‐induced senescence in Arabidopsis thaliana

Plant, cell and environment, 2023-03, Vol.46 (3), p.901-917

2023

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Milk and milk‐derived peptides combat against hypertension and vascular dysfunction: a review

International journal of food science & technology, 2019-06, Vol.54 (6), p.1920-1929

2019

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Is proline accumulation per se correlated with stress tolerance or is proline homeostasis a more critical issue?

Plant, cell and environment, 2014-02, Vol.37 (2), p.300-311

2014

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Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress

Free radical biology & medicine, 2008-02, Vol.44 (4), p.671-681

2008

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Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase

British journal of haematology, 2023-05, Vol.201 (4), p.704-717

2023

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Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line

PloS one, 2018-04, Vol.13 (4), p.e0196283

2018

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Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2848-2865

2022

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Properties, metabolisms, and applications of l-proline analogues

Applied microbiology and biotechnology, 2013-08, Vol.97 (15), p.6623-6634

2013

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Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase

Organic & biomolecular chemistry, 2022-01, Vol.2 (4), p.895-95

2022

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Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104)

The Journal of biological chemistry, 2022-03, Vol.298 (3), p.101708-101708, Article 101708

2022

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Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

Amino acids, 2021-12, Vol.53 (12), p.1891-1902

2021

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MMP generated matrikines

Matrix biology, 2015-05, Vol.44-46, p.122-129

2015

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R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe-3-Hydroxypipecolic Acid

Screening a knowledge‐based library of low molecular weight compounds against the proline biosynthetic enzyme 1‐pyrroline‐5‐carboxylate 1 (PYCR1)

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Structures of l‐proline trans‐hydroxylase reveal the catalytic specificity and provide deeper insight into AKG‐dependent hydroxylation

Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy

Structure, function, and mechanism of proline utilization A (PutA)

Structural Biology of Proline Catabolic Enzymes

Discovery and quantification of bioactive peptides in fermented cucumber by direct analysis IR-MALDESI mass spectrometry and LC-QQQ-MS

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Proline metabolism in cancer

Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties

Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

Pyrroline‐5‐carboxylate dehydrogenase is an essential enzyme for proline dehydrogenase function during dark‐induced senescence in Arabidopsis thaliana

Milk and milk‐derived peptides combat against hypertension and vascular dysfunction: a review

Is proline accumulation per se correlated with stress tolerance or is proline homeostasis a more critical issue?

Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress

Proline promotes proliferation and drug resistance of multiple myeloma by downregulation of proline dehydrogenase

Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV‑2 Main Protease Inhibitors

Properties, metabolisms, and applications of l-proline analogues

Structure-affinity relationships of reversible proline analog inhibitors targeting proline dehydrogenase

Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104)

Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy

MMP generated matrikines

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