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"To serve and protect": enzyme inhibitors as radiopeptide escorts promote tumor targeting

Journal of Nuclear Medicine, 2014-01, Vol.55 (1), p.121-127

2014

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Metabolically Stabilized (68)Ga-NOTA-Bombesin for PET Imaging of Prostate Cancer and Influence of Protease Inhibitor Phosphoramidon

Molecular pharmaceutics, 2016-04, Vol.13 (4), p.1347-1357

2016

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In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies

Theranostics, 2016, Vol.6 (1), p.104-117

2016

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Comparing Gly11/dAla11-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the 111In-SB3/111In-SB4 Radiotracer Pair

Molecules (Basel, Switzerland), 2019-03, Vol.24 (6), p.1015

2019

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Matrix metalloproteinase-dependent regulation of extracellular matrix shapes the structure of sexually differentiating mouse gonads

Differentiation (London), 2019-03, Vol.106, p.23-34

2019

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[ 99m Tc]Tc-DB1 Mimics with Different-Length PEG Spacers: Preclinical Comparison in GRPR-Positive Models

Molecules (Basel, Switzerland), 2020-07, Vol.25 (15), p.3418

2020

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In vivo inhibition of neutral endopeptidase enhances the diagnostic potential of truncated gastrin 111In-radioligands

Nuclear medicine and biology, 2015-11, Vol.42 (11), p.824-832

2015

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Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24

Acta crystallographica. Section D, Biological crystallography., 2018-08, Vol.74 (8), p.739-747

2018

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Localization of 99mTc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

Pharmaceuticals (Basel, Switzerland), 2019-03, Vol.12 (1), p.42

2019

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Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

Brain research, 2013-07, Vol.1520, p.145-156

2013

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Comparative evaluation of the new GRPR‐antagonist 111In‐SB9 and 111In‐AMBA in prostate cancer models: Implications of in vivo stability

Journal of labelled compounds & radiopharmaceuticals, 2019-08, Vol.62 (10), p.646-655

2019

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.24540-24548

2001

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Radiolabeled gastrin/CCK analogs in tumor diagnosis: towards higher stability and improved tumor targeting

The quarterly journal of nuclear medicine and molecular imaging, 2015-09, Vol.59 (3), p.287

2015

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Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease

Journal of Alzheimer's disease, 2013-01, Vol.33 Suppl 1 (s1), p.S101-S110

2013

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Improving the In Vivo Profile of Minigastrin Radiotracers: A Comparative Study Involving the Neutral Endopeptidase Inhibitor Phosphoramidon

Cancer biotherapy & radiopharmaceuticals, 2016-02, Vol.31 (1), p.20-28

2016

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Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine

Reischl, Gerald

2019

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In vivo inhibition of neutral endopeptidase enhances the diagnostic potential of truncated gastrin (111)In-radioligands

Nuclear medicine and biology, 2015-11, Vol.42 (11), p.824-832

2015

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Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan

Acta crystallographica. Section F, Structural biology communications, 2019-06, Vol.75 (6), p.405-411

2019

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Arrhythmogenic Action of Endothelin-11–31 Through Conversion to Endothelin-11–21

Experimental biology and medicine (Maywood, N.J.), 2006-06, Vol.231 (6), p.937-941

2006

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Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-l-rhamnose triacetate upon phosphitylation

Bioorganic & medicinal chemistry, 2013-11, Vol.21 (21), p.6778-6787

2013

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Inhibition of neuropeptide degradation suppresses sweating but increases the area of the axon reflex flare

Experimental dermatology, 2013-04, Vol.22 (4), p.299-301

2013

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Structure of human Endothelin-converting Enzyme I Complexed with Phosphoramidon

Journal of molecular biology, 2009-01, Vol.385 (1), p.178-187

2009

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Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

Journal of molecular biology, 2000-02, Vol.296 (2), p.341-349

2000

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An Improved H-Phosphonate Approach for Practical Synthesis of Phosphoramidon

Phosphorus, sulfur, and silicon and the related elements, 2014-12, Vol.189 (12), p.1887-1894

2014

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Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

FEBS letters, 2008-07, Vol.582 (16), p.2382-2386

2008

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"To serve and protect": enzyme inhibitors as radiopeptide escorts promote tumor targeting

Metabolically Stabilized (68)Ga-NOTA-Bombesin for PET Imaging of Prostate Cancer and Influence of Protease Inhibitor Phosphoramidon

In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies

Comparing Gly11/dAla11-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the 111In-SB3/111In-SB4 Radiotracer Pair

Matrix metalloproteinase-dependent regulation of extracellular matrix shapes the structure of sexually differentiating mouse gonads

[ 99m Tc]Tc-DB1 Mimics with Different-Length PEG Spacers: Preclinical Comparison in GRPR-Positive Models

In vivo inhibition of neutral endopeptidase enhances the diagnostic potential of truncated gastrin 111In-radioligands

Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24

Localization of 99mTc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

Comparative evaluation of the new GRPR‐antagonist 111In‐SB9 and 111In‐AMBA in prostate cancer models: Implications of in vivo stability

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

Radiolabeled gastrin/CCK analogs in tumor diagnosis: towards higher stability and improved tumor targeting

Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease

Improving the In Vivo Profile of Minigastrin Radiotracers: A Comparative Study Involving the Neutral Endopeptidase Inhibitor Phosphoramidon

Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine

In vivo inhibition of neutral endopeptidase enhances the diagnostic potential of truncated gastrin (111)In-radioligands

Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan

Arrhythmogenic Action of Endothelin-11–31 Through Conversion to Endothelin-11–21

Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-l-rhamnose triacetate upon phosphitylation

Inhibition of neuropeptide degradation suppresses sweating but increases the area of the axon reflex flare

Structure of human Endothelin-converting Enzyme I Complexed with Phosphoramidon

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

An Improved H-Phosphonate Approach for Practical Synthesis of Phosphoramidon

Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

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