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Nineteen-step total synthesis of (+)-phorbol

Nature (London), 2016-04, Vol.532 (7597), p.90-93

2016

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Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.11698-11703

2013

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Molecular dynamics simulation studies on binding of activator and inhibitor to Munc13-1 C1 in the presence of membrane

Journal of biomolecular structure & dynamics, 2022-01, Vol.40 (24), p.14160-14175

2022

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Protein kinase C pharmacology: refining the toolbox

Biochemical journal, 2013-06, Vol.452 (2), p.195-209

2013

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Untargeted Metabolomic Analysis of Leaves and Roots of Jatropha curcas Genotypes with Contrasting Levels of Phorbol Esters

Physiologia plantarum, 2024-03, Vol.176 (2), p.e14274-n/a

2024

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Phorbol Esters: Structure, Biological Activity, and Toxicity in Animals

International journal of toxicology, 2007-07, Vol.26 (4), p.279-288

2007

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Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae

Molecules (Basel, Switzerland), 2017-09, Vol.22 (9), p.1498

2017

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Comparison of the ligand binding site of C1 domains: a molecular dynamics simulation study of the C1 domain-phorbol 13-acetate-membrane system

Journal of biomolecular structure & dynamics, 2023, Vol.ahead-of-print (ahead-of-print), p.1-14

2023

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Biphasic alcoholysis coupled with high‐speed countercurrent chromatography for high performance on separating phorbol from Croton tiglium Linn extracts

Journal of separation science, 2023-04, Vol.46 (8), p.e2200984-n/a

2023

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Genome sequence of Jatropha curcas L., a non‐edible biodiesel plant, provides a resource to improve seed‐related traits

Plant biotechnology journal, 2019-02, Vol.17 (2), p.517-530

2019

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New phorbol ester derivatives as potent anti-HIV agents

Bioorganic & medicinal chemistry letters, 2021-10, Vol.50, p.128319-128319, Article 128319

2021

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Tigliane-Type Diterpene Esters from the Fruits of Shirakiopsis indica and Their Anti-HIV Activity

Journal of natural products (Washington, D.C.), 2022-11, Vol.85 (11), p.2687-2693

2022

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Traditional detoxification of Jatropha curcas L. seeds

Journal of ethnopharmacology, 2019-09, Vol.241, p.111970, Article 111970

2019

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Protein kinase C as a tumor suppressor

Seminars in cancer biology, 2018-02, Vol.48, p.18-26

Newton, Alexandra C

2018

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Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Nature communications, 2017-02, Vol.8 (1), p.6-6, Article 6

2017

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Number of Hydroxyl Groups on the B‑Ring of Flavonoids Affects Their Antioxidant Activity and Interaction with Phorbol Ester Binding Site of PKCδ C1B Domain: In Vitro and in Silico Studies

Journal of agricultural and food chemistry, 2015-05, Vol.63 (18), p.4580-4586

2015

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Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells

Biochemical and biophysical research communications, 2018-01, Vol.496 (1), p.225-230

2018

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12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7579

2020

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Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis

International journal of molecular sciences, 2016-03, Vol.17 (3), p.398-398

2016

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Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium

Planta medica, 2017-11, Vol.83 (17), p.1361-1367

2017

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Activation of medullary dorsal horn γ isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia

The European journal of neuroscience, 2016-03, Vol.43 (6), p.802-810

2016

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Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines

Biochemical and biophysical research communications, 2018-01, Vol.495 (1), p.438-445

2018

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Roles of the α[sub.1B]-Adrenergic Receptor Phosphorylation Domains in Signaling and Internalization

International journal of molecular sciences, 2023-11, Vol.24 (23)

2023

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The story of PKC: A discovery marked by unexpected twists and turns

IUBMB life, 2019-06, Vol.71 (6), p.697-705

Kikkawa, Ushio

2019

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Nineteen-step total synthesis of (+)-phorbol

Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

Molecular dynamics simulation studies on binding of activator and inhibitor to Munc13-1 C1 in the presence of membrane

Protein kinase C pharmacology: refining the toolbox

Untargeted Metabolomic Analysis of Leaves and Roots of Jatropha curcas Genotypes with Contrasting Levels of Phorbol Esters

Phorbol Esters: Structure, Biological Activity, and Toxicity in Animals

Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae

Comparison of the ligand binding site of C1 domains: a molecular dynamics simulation study of the C1 domain-phorbol 13-acetate-membrane system

Biphasic alcoholysis coupled with high‐speed countercurrent chromatography for high performance on separating phorbol from Croton tiglium Linn extracts

Genome sequence of Jatropha curcas L., a non‐edible biodiesel plant, provides a resource to improve seed‐related traits

New phorbol ester derivatives as potent anti-HIV agents

Tigliane-Type Diterpene Esters from the Fruits of Shirakiopsis indica and Their Anti-HIV Activity

Traditional detoxification of Jatropha curcas L. seeds

Protein kinase C as a tumor suppressor

Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Number of Hydroxyl Groups on the B‑Ring of Flavonoids Affects Their Antioxidant Activity and Interaction with Phorbol Ester Binding Site of PKCδ C1B Domain: In Vitro and in Silico Studies

Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells

12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway

Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis

Isolation and Structure Characterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium

Activation of medullary dorsal horn γ isoform of protein kinase C interneurons is essential to the development of both static and dynamic facial mechanical allodynia

Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines

Roles of the α[sub.1B]-Adrenergic Receptor Phosphorylation Domains in Signaling and Internalization

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection

The story of PKC: A discovery marked by unexpected twists and turns

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