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Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update

Medicinal research reviews, 2019-09, Vol.39 (5), p.1603-1706

2019

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Design, synthesis and biological evaluation of 4′-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease

Bioorganic & medicinal chemistry, 2017-02, Vol.25 (3), p.1030-1041

2017

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Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease

Bioorganic & medicinal chemistry, 2022-03, Vol.58, p.116660-116660, Article 116660

2022

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Multitarget drug design strategy against Alzheimer’s disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.714-726

2017

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Design, synthesis and evaluation of novel monoamine oxidase B (MAO-B) inhibitors with improved pharmacokinetic properties for Parkinson's disease

European journal of medicinal chemistry, 2023-04, Vol.252, p.115308-115308, Article 115308

2023

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Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans -6-Styrylcoumarin

Molecules (Basel, Switzerland), 2022-01, Vol.27 (3), p.928

2022

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Correlation intensity index-index of ideality of correlation: A hyphenated target function for furtherance of MAO-B inhibitory activity assessment

Computational biology and chemistry, 2024-02, Vol.108, p.107975-107975, Article 107975

2024

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Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?

Expert opinion on drug discovery, 2019-10, Vol.14 (10), p.995-1035

2019

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Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1195-1210

2019

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Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study

European journal of medicinal chemistry, 2022-01, Vol.228, p.114025-114025, Article 114025

2022

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Calycosin and 8-O-methylretusin isolated from Maackia amurensis as potent and selective reversible inhibitors of human monoamine oxidase-B

International journal of biological macromolecules, 2020-05, Vol.151, p.441-448

2020

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3-Arylcoumarins as highly potent and selective monoamine oxidase B inhibitors: Which chemical features matter?

Bioorganic chemistry, 2020-08, Vol.101, p.103964, Article 103964

2020

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Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B

Molecules (Basel, Switzerland), 2022-12, Vol.28 (1), p.258

2022

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Indoles and 1-(3-(benzyloxy)benzyl)piperazines: Reversible and selective monoamine oxidase B inhibitors identified by screening an in-house compound library

Bioorganic chemistry, 2022-02, Vol.119, p.105581-105581, Article 105581

2022

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Efficacy of selegiline add on therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled study

Human psychopharmacology, 2008-03, Vol.23 (2), p.79-86

2008

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Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease

European journal of medicinal chemistry, 2019-10, Vol.180, p.238-252

2019

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Polyphenolic Glycosides from the Fruits Extract of Lycium ruthenicum Murr and Their Monoamine Oxidase B Inhibitory and Neuroprotective Activities

Journal of agricultural and food chemistry, 2022-07, Vol.70 (26), p.7968-7980

2022

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Aldoxime- and hydroxy-functionalized chalcones as highly potent and selective monoamine oxidase-B inhibitors

Journal of molecular structure, 2022-02, Vol.1250, p.131817, Article 131817

2022

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Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease

European journal of medicinal chemistry, 2019-09, Vol.178, p.726-739

2019

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Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease: A Review of Symptomatic and Potential Disease-Modifying Effects

CNS drugs, 2011-12, Vol.25 (12), p.1061-1071

Schapira, Anthony H. V.

2011

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Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine

European journal of pharmacology, 2010-07, Vol.637 (1), p.77-82

2010

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Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines

Journal of molecular structure, 2022-04, Vol.1254, p.132280, Article 132280

2022

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Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer's Disease: AChE, MAO-B, and COX-2 as Molecular Targets

Molecules (Basel, Switzerland), 2024-01, Vol.29 (2), p.490

2024

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Safinamide for the treatment of Parkinson's disease

Expert opinion on investigational drugs, 2014-05, Vol.23 (5), p.729-742

2014

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Discovery and optimization of 3-thiophenylcoumarins as novel agents against Parkinson’s disease: Synthesis, in vitro and in vivo studies

Bioorganic chemistry, 2020-08, Vol.101, p.103986, Article 103986

2020

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Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update

Design, synthesis and biological evaluation of 4′-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease

Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease

Multitarget drug design strategy against Alzheimer’s disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties

Design, synthesis and evaluation of novel monoamine oxidase B (MAO-B) inhibitors with improved pharmacokinetic properties for Parkinson's disease

Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans -6-Styrylcoumarin

Correlation intensity index-index of ideality of correlation: A hyphenated target function for furtherance of MAO-B inhibitory activity assessment

Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study

Calycosin and 8-O-methylretusin isolated from Maackia amurensis as potent and selective reversible inhibitors of human monoamine oxidase-B

3-Arylcoumarins as highly potent and selective monoamine oxidase B inhibitors: Which chemical features matter?

Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B

Indoles and 1-(3-(benzyloxy)benzyl)piperazines: Reversible and selective monoamine oxidase B inhibitors identified by screening an in-house compound library

Efficacy of selegiline add on therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled study

Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease

Polyphenolic Glycosides from the Fruits Extract of Lycium ruthenicum Murr and Their Monoamine Oxidase B Inhibitory and Neuroprotective Activities

Aldoxime- and hydroxy-functionalized chalcones as highly potent and selective monoamine oxidase-B inhibitors

Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease

Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease: A Review of Symptomatic and Potential Disease-Modifying Effects

Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine

Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines

Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer's Disease: AChE, MAO-B, and COX-2 as Molecular Targets

Safinamide for the treatment of Parkinson's disease

Discovery and optimization of 3-thiophenylcoumarins as novel agents against Parkinson’s disease: Synthesis, in vitro and in vivo studies

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