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Rational design, synthesis, and biophysical characterization of a peptidic MDM2-MDM4 interaction inhibitor

Bioorganic & medicinal chemistry, 2024-11, Vol.113, p.117937, Article 117937

2024

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miR-34a-5p enhances the sensitivity of cervical cancer cells to oxaliplatin chemotherapy via targeting MDM4

Clinical and experimental obstetrics & gynecology, 2022-02, Vol.49 (2), p.54

2022

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MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4

Oncotarget, 2017-05, Vol.8 (18), p.29914-29924

2017

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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

Cell reports (Cambridge), 2024-08, Vol.43 (8), p.114622, Article 114622

2024

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Targeting p53 for the treatment of cancer

Seminars in cancer biology, 2022-02, Vol.79, p.58-67

2022

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Lack of Associations of the MDM4 rs4245739 Polymorphism with Risk of Thyroid Cancer among Iranian-Azeri Patients: a Case-Control Study

Asian Pacific journal of cancer prevention : APJCP, 2017-04, Vol.18 (4), p.1133-1138

2017

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Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis

Oncotarget, 2019-08, Vol.10 (49), p.5007-5010

2019

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Comparative Clinicopathologic and Genomic Analysis of Hepatocellular Neoplasm, Not Otherwise Specified, and Hepatoblastoma

Modern pathology, 2024-02, Vol.37 (2), p.100385-100385, Article 100385

2024

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MDM2, MDM4 and EGFR Amplifications and Hyperprogression in Metastatic Acral and Mucosal Melanoma

Cancers, 2020-02, Vol.12 (3), p.540

2020

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Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway

Genes & cancer, 2010-04, Vol.1 (4), p.360-368

2010

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Astaxanthin protects against pirarubicin-induced H9c2 cardiomyocytes by adjusting microRNA-494-3p-mediated MDM4/p53 signalling pathway

Journal of pharmacy and pharmacology, 2023-12, Vol.75 (12), p.1521-1529

2023

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Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects

Oncotarget, 2018-01, Vol.9 (7), p.7282-7297

2018

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Mdm2 and MdmX as Regulators of Gene Expression

Genes & cancer, 2012-03, Vol.3 (3-4), p.264-273

2012

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Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis

Gene, 2021-08, Vol.793, p.145747-145747, Article 145747

2021

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Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Cell stem cell, 2023-02, Vol.30 (2), p.153-170.e9

2023

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A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

Genes & development, 2014-03, Vol.28 (5), p.438-450

2014

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MiR-483-3p inhibition ameliorates myocardial ischemia/reperfusion injury by targeting the MDM4/p53 pathway

Molecular immunology, 2020-09, Vol.125, p.9-14

2020

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Brentuximab vedotin as a bridge to combination chemotherapy in gray zone lymphoma with severe liver impairment: a case report

Frontiers in oncology, 2024-01, Vol.13, p.1254256

2024

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A feed-forward loop between LncRNA- KCNQ1OT1 and MDM4 promotes metastasis of colorectal cancer

Asian journal of surgery, 2024-09, Vol.47 (9), p.3995-3997

2024

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Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program

Molecular cell, 2020-11, Vol.80 (3), p.452-469.e9

2020

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LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis

Cellular and Molecular Biology, 2023-06, Vol.69 (6), p.181-185

2023

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MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4

Vascular, 2023-06, Vol.31 (3), p.608-618

2023

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Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

Journal of experimental & clinical cancer research, 2021-08, Vol.40 (1), p.254-254, Article 254

2021

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Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma

Frontiers in oncology, 2019-11, Vol.9, p.1260-1260

2019

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Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

Genes & development, 2013-09, Vol.27 (17), p.1903-1916

2013

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Rational design, synthesis, and biophysical characterization of a peptidic MDM2-MDM4 interaction inhibitor

miR-34a-5p enhances the sensitivity of cervical cancer cells to oxaliplatin chemotherapy via targeting MDM4

MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4

RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

Targeting p53 for the treatment of cancer

Lack of Associations of the MDM4 rs4245739 Polymorphism with Risk of Thyroid Cancer among Iranian-Azeri Patients: a Case-Control Study

Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis

Comparative Clinicopathologic and Genomic Analysis of Hepatocellular Neoplasm, Not Otherwise Specified, and Hepatoblastoma

MDM2, MDM4 and EGFR Amplifications and Hyperprogression in Metastatic Acral and Mucosal Melanoma

Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway

Astaxanthin protects against pirarubicin-induced H9c2 cardiomyocytes by adjusting microRNA-494-3p-mediated MDM4/p53 signalling pathway

Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects

Mdm2 and MdmX as Regulators of Gene Expression

Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis

Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

MiR-483-3p inhibition ameliorates myocardial ischemia/reperfusion injury by targeting the MDM4/p53 pathway

Brentuximab vedotin as a bridge to combination chemotherapy in gray zone lymphoma with severe liver impairment: a case report

A feed-forward loop between LncRNA- KCNQ1OT1 and MDM4 promotes metastasis of colorectal cancer

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program

LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis

MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

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