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I08 Passive immunization, with the anti-huntingtin aggregate antibody EM48, is beneficial in R6/2 mouse model

Journal of neurology, neurosurgery and psychiatry, 2022-09, Vol.93 (Suppl 1), p.A87-A87

2022

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I04 Aav5-mihtt gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington disease minipigs up to 4 years

Journal of neurology, neurosurgery and psychiatry, 2022-09, Vol.93 (Suppl 1), p.A86-A86

2022

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Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates

Biochemical and biophysical research communications, 2020-01, Vol.522 (1), p.133-137

2020

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A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

Autophagy, 2023-02, Vol.19 (2), p.544-550

2023

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A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington's disease

Journal of neuroinflammation, 2022-02, Vol.19 (1), p.56-56, Article 56

2022

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Visualization of Mutant Aggregates from Clock Neurons by Agarose Gel Electrophoresis (AGERA) in Drosophila melanogaster

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2482, p.373

2022

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Passive immunization against phosphorylated tau improves features of Huntington's disease pathology

Molecular therapy, 2022-04, Vol.30 (4), p.1500-1522

2022

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Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis

Proceedings of the National Academy of Sciences - PNAS, 2024-03, Vol.121 (13), p.e2313652121

2024

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Dysregulation of long non‐coding RNAs and their mechanisms in Huntington's disease

Journal of neuroscience research, 2021-09, Vol.99 (9), p.2074-2090

2021

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Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

Frontiers in pharmacology, 2020-02, Vol.11, p.116-116

2020

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Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model

Frontiers in aging neuroscience, 2023-08, Vol.15, p.1237018-1237018

2023

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Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

Autophagy, 2015-04, Vol.11 (4), p.685-700

2015

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Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?

BioEssays, 2020-06, Vol.42 (6), p.e1900231-n/a

Subramaniam, Srinivasa

2020

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Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

European journal of nuclear medicine and molecular imaging, 2022-03, Vol.49 (4), p.1166-1175

2022

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Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective

Frontiers in aging neuroscience, 2023-05, Vol.15, p.1175598-1175598

2023

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Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice

Molecular brain, 2019-04, Vol.12 (1), p.35-35, Article 35

2019

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Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes

CNS & neurological disorders drug targets, 2023-01, Vol.22 (3), p.404-416

2023

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Therapeutic Advances for Huntington's Disease

Brain sciences, 2020-01, Vol.10 (1), p.43

2020

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Peripheral Biomarkers in Manifest and Premanifest Huntington's Disease

International journal of molecular sciences, 2023-03, Vol.24 (7), p.6051

2023

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Selective Neuronal Death in Neurodegenerative Diseases: The Ongoing Mystery

The Yale journal of biology & medicine, 2019-12, Vol.92 (4), p.695-705

Subramaniam, Srinivasa

2019

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Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice

Frontiers in neuroscience, 2021-06, Vol.15, p.682172-682172

2021

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Design, Synthesis, and Structure-Activity Relationship Study of Potent MAPK11 Inhibitors

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.203

2021

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Altered reactivity of central amygdala to GABAAR antagonist in the BACHD rat model of Huntington disease

Neuropharmacology, 2017-09, Vol.123 (3), p.136-147

2017

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Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Cell & bioscience, 2022-10, Vol.12 (1), p.1-167, Article 167

2022

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I08 Passive immunization, with the anti-huntingtin aggregate antibody EM48, is beneficial in R6/2 mouse model

I04 Aav5-mihtt gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington disease minipigs up to 4 years

An exploration of the genetics of the mutant Huntingtin (mHtt) gene in a cohort of patients with chorea from different ethnic groups in sub-Saharan Africa

Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates

A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington's disease

Visualization of Mutant Aggregates from Clock Neurons by Agarose Gel Electrophoresis (AGERA) in Drosophila melanogaster

Passive immunization against phosphorylated tau improves features of Huntington's disease pathology

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis

Dysregulation of long non‐coding RNAs and their mechanisms in Huntington's disease

Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model

Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice

Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes

Therapeutic Advances for Huntington's Disease

Peripheral Biomarkers in Manifest and Premanifest Huntington's Disease

Selective Neuronal Death in Neurodegenerative Diseases: The Ongoing Mystery

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice

Design, Synthesis, and Structure-Activity Relationship Study of Potent MAPK11 Inhibitors

Altered reactivity of central amygdala to GABAAR antagonist in the BACHD rat model of Huntington disease

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

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