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The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

Molecules (Basel, Switzerland), 2022-01, Vol.27 (1), p.273

2022

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L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences

Neuropharmacology, 2017-01, Vol.112 (Pt B), p.264-274

2017

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The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

Current biology, 2011-06, Vol.21 (11), p.961-966

2011

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Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases

Cellular and molecular life sciences : CMLS, 2017-08, Vol.74 (16), p.2899-2916

2017

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Major Developments in the Design of Inhibitors along the Kynurenine Pathway

Current medicinal chemistry, 2017-01, Vol.24 (23), p.2471

2017

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Kynurenine emerges from the shadows – Current knowledge on its fate and function

Pharmacology & therapeutics (Oxford), 2021-09, Vol.225, p.107845, Article 107845

2021

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The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

The Journal of pharmacology and experimental therapeutics, 2015-10, Vol.355 (1), p.76

2015

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Kynurenine‐3‐monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression

Journal of cellular physiology, 2022-12, Vol.237 (12), p.4339-4355

2022

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Nature (London), 2011-10, Vol.478 (7368), p.197-203

2011

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A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation

Biochimica et biophysica acta. Molecular basis of disease, 2024-02, Vol.1870 (2), p.166929-166929, Article 166929

2024

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Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain

The Journal of biological chemistry, 2013-12, Vol.288 (51), p.36554-36566

2013

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Kynurenine 3-monooxygenase limits de novo NAD + synthesis through dietary tryptophan in renal proximal tubule epithelial cell models

American Journal of Physiology: Cell Physiology, 2024-05, Vol.326 (5), p.C1423-C1436

2024

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The Kynurenine Pathway-New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies

International journal of molecular sciences, 2021-09, Vol.22 (18), p.9879

2021

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Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics

Analytical chemistry (Washington), 2020-07, Vol.92 (13), p.8836-8844

2020

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Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis

Neuropsychopharmacology (New York, N.Y.), 2012-03, Vol.37 (4), p.939-949

2012

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The kynurenine pathway and neurodegenerative disease

Seminars in cell & developmental biology, 2015-04, Vol.40, p.134-141

2015

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Central kynurenine pathway shift with age in women

Journal of neurochemistry, 2016-03, Vol.136 (5), p.995-1003

2016

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HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway

Brain, behavior, and immunity, 2018-08, Vol.72, p.51-60

2018

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Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Journal of bone and mineral research, 2017-11, Vol.32 (11), p.2182-2193

2017

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LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain

Bioanalysis, 2016-09, Vol.8 (18), p.1903-1917

2016

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Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study

Psychoneuroendocrinology, 2019-02, Vol.100, p.213-222

2019

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Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson’s Disease Patients

Molecular neurobiology, 2024-07, Vol.61 (7), p.3867-3881

2024

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Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder

Brain, behavior, and immunity, 2016-03, Vol.53, p.39-48

2016

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Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain

Toxicology and applied pharmacology, 2023-02, Vol.461, p.116382, Article 116382

2023

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The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases

Major Developments in the Design of Inhibitors along the Kynurenine Pathway

Kynurenine emerges from the shadows – Current knowledge on its fate and function

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

Kynurenine‐3‐monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation

Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain

Kynurenine 3-monooxygenase limits de novo NAD + synthesis through dietary tryptophan in renal proximal tubule epithelial cell models

The Kynurenine Pathway-New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics

Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis

The kynurenine pathway and neurodegenerative disease

Central kynurenine pathway shift with age in women

HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain

Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study

Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson’s Disease Patients

Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder

Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain

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