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Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

International Journal of Tryptophan Research, 2017, Vol.2017 (10), p.1178646917691938-1178646917691938

Badawy, Abdulla A-B

2017

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Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation

Journal of Atherosclerosis and Thrombosis, 2020, pp.58248

2020

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Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease

Medical hypotheses, 2018-09, Vol.118, p.129-138

Badawy, Abdulla A.-B.

2018

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The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases

Journal of allergy and clinical immunology, 2016-06, Vol.137 (6), p.1830-1840

2016

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KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer

Journal of Cancer, 2024-01, Vol.15 (9), p.2475-2485

2024

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Serum profiles of tryptophan-kynurenine pathway metabolites in psoriasis

Exploration of immunology, 2021-09, Vol.1 (4), p.258-268

2021

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Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism

Bone (New York, N.Y.), 2020-04, Vol.133, p.115219-115219, Article 115219

2020

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A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation

Biochimica et biophysica acta. Molecular basis of disease, 2024-02, Vol.1870 (2), p.166929-166929, Article 166929

2024

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Metabolic Modulation of Kynurenine Based on Kynureninase-Loaded Nanoparticle Depot Overcomes Tumor Immune Evasion in Cancer Immunotherapy

ACS applied materials & interfaces, 2024-04, Vol.16 (15), p.18490-18502

2024

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Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Advanced science, 2023-02, Vol.10 (6), p.e2204006-n/a

2023

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Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation

Journal of Atherosclerosis and Thrombosis, 2021/11/01, Vol.28(11), pp.1214-1240

2021

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Kynureninase Promotes Immunosuppression and Predicts Survival in Glioma Patients: In Silico Data Analyses of the Chinese Glioma Genome Atlas (CGGA) and of the Cancer Genome Atlas (TCGA)

Pharmaceuticals (Basel, Switzerland), 2023-02, Vol.16 (3), p.369

2023

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The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans

The Journal of biological chemistry, 2019-07, Vol.294 (28), p.11047-11053

2019

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Anthranilic Acid, a GPR109A Agonist, and Schizophrenia

International journal of tryptophan research, 2024-01, Vol.17, p.11786469241239125-11786469241239125

2024

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The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice

American journal of Alzheimer's disease and other dementias, 2023-01, Vol.38, p.15333175231214861

2023

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Kynureninase knockdown inhibits cisplatin resistance in vivo and in vitro and impacts the prognosis of cervical adenocarcinoma

Cell division, 2023-09, Vol.18 (1), p.1-15, Article 15

2023

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The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay

International journal of molecular sciences, 2022-01, Vol.23 (2), p.641

2022

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Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion

International journal of tryptophan research, 2016-01, Vol.2016 (9), p.31-49

2016

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Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine

Journal of psychiatric research, 2013-11, Vol.47 (11), p.1815-1823

2013

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Loss of Indoleamine-2,3-Dioxygenase-1 (IDO1) in Knockout Mice Does Not Affect the Development of Skin Lesions in the Imiquimod-Induced Mouse Model of Psoriasis

International journal of tryptophan research, 2022, Vol.15, p.11786469221078191-11786469221078191

2022

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Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors

International Journal of Tryptophan Research, 2016-01, Vol.2016 (2016), p.51-65

2016

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Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn's Disease

Journal of clinical medicine, 2020-05, Vol.9 (5), p.1360

2020

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Proteomic analysis of lipopolysaccharide activated human monocytes

Molecular immunology, 2018-11, Vol.103, p.257-269

2018

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Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease

Journal of neurochemistry, 2010-06, Vol.113 (6), p.1416-1425

2010

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Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation

Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease

The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases

KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer

Serum profiles of tryptophan-kynurenine pathway metabolites in psoriasis

Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism

A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation

Metabolic Modulation of Kynurenine Based on Kynureninase-Loaded Nanoparticle Depot Overcomes Tumor Immune Evasion in Cancer Immunotherapy

Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma

Upregulated Kynurenine Pathway Enzymes in Aortic Atherosclerotic Aneurysm: Macrophage Kynureninase Downregulates Inflammation

Kynureninase Promotes Immunosuppression and Predicts Survival in Glioma Patients: In Silico Data Analyses of the Chinese Glioma Genome Atlas (CGGA) and of the Cancer Genome Atlas (TCGA)

The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans

Anthranilic Acid, a GPR109A Agonist, and Schizophrenia

The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice

Kynureninase knockdown inhibits cisplatin resistance in vivo and in vitro and impacts the prognosis of cervical adenocarcinoma

The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay

Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion

Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine

Loss of Indoleamine-2,3-Dioxygenase-1 (IDO1) in Knockout Mice Does Not Affect the Development of Skin Lesions in the Imiquimod-Induced Mouse Model of Psoriasis

Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors

Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn's Disease

Proteomic analysis of lipopolysaccharide activated human monocytes

Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease

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