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A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation

The Journal of biological chemistry, 2020-11, Vol.295 (46), p.15650-15661

2020

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Structural basis of antifolate recognition and transport by PCFT

Nature (London), 2021-07, Vol.595 (7865), p.130-134

2021

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Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

Annual review of nutrition, 2011-08, Vol.31 (1), p.177-201

2011

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The intestinal absorption of folates

Annual review of physiology, 2014-01, Vol.76 (1), p.251-274

2014

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Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1

Current Topics in Membranes, 2014, Vol.73, p.175-204

2014

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The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

Cancer biology & therapy, 2012-12, Vol.13 (14), p.1355-1373

2012

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Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation

The Journal of biological chemistry, 2019-05, Vol.294 (18), p.7245-7258

2019

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Regulation of folate transport at the mouse arachnoid barrier

Fluids and barriers of the CNS, 2024-08, Vol.21 (1), p.67-12

2024

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Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function

American Journal of Physiology: Cell Physiology, 2016-07, Vol.311 (1), p.C150-C157

2016

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Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

Biochemical journal, 2015-07, Vol.469 (1), p.33-44

2015

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The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

Cancer chemotherapy and pharmacology, 2018-01, Vol.81 (1), p.1-15

2018

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The evolving biology of the proton‐coupled folate transporter: New insights into regulation, structure, and mechanism

The FASEB journal, 2022-02, Vol.36 (2), p.e22164-n/a

2022

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Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Scientific reports, 2021-03, Vol.11 (1), p.6389-14, Article 6389

2021

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Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter

The Journal of biological chemistry, 2012-02, Vol.287 (7), p.4982-4995

2012

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Two maize homologs of mammalian proton-coupled folate transporter, ZmMFS_1–62 and ZmMFS_1–73, are essential to salt and drought tolerance

Plant physiology and biochemistry, 2024-05, Vol.210, p.108623, Article 108623

2024

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Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method

American Journal of Physiology: Cell Physiology, 2013-06, Vol.304 (12), p.C1159-C1167

2013

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Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

Nature communications, 2021-01, Vol.12 (1), p.290-12, Article 290

2021

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The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.632-649

2014

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Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking

The Journal of biological chemistry, 2016-04, Vol.291 (15), p.8162-8172

2016

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Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

Biochimica et biophysica acta. Biomembranes, 2017-11, Vol.1859 (11), p.2193-2202

2017

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Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1)

American Journal of Physiology: Cell Physiology, 2018-03, Vol.314 (3), p.C289-C296

2018

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Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer

Oral diseases, 2024-05, Vol.30 (4), p.1989-2003

2024

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Folate Transporters in Placentas from Preterm Newborns and Their Relation to Cord Blood Folate and Vitamin B12 Levels

PloS one, 2017-01, Vol.12 (1), p.e0170389-e0170389

2017

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Folate‐appended cyclodextrin carrier targets ovarian cancer cells expressing the proton‐coupled folate transporter

Cancer science, 2020-05, Vol.111 (5), p.1794-1804

2020

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A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation

Structural basis of antifolate recognition and transport by PCFT

Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

The intestinal absorption of folates

Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation

Regulation of folate transport at the mouse arachnoid barrier

Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function

Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

The evolving biology of the proton‐coupled folate transporter: New insights into regulation, structure, and mechanism

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter

Two maize homologs of mammalian proton-coupled folate transporter, ZmMFS_1–62 and ZmMFS_1–73, are essential to salt and drought tolerance

Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method

Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1)

Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer

Folate Transporters in Placentas from Preterm Newborns and Their Relation to Cord Blood Folate and Vitamin B12 Levels

Folate‐appended cyclodextrin carrier targets ovarian cancer cells expressing the proton‐coupled folate transporter

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