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Deguelin inhibits the glioblastoma progression through suppressing CCL2/NFκB signaling pathway

Neuropharmacology, 2024-11, Vol.259, p.110109, Article 110109

2024

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The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway

Reproductive toxicology (Elmsford, N.Y.), 2023-09, Vol.120, p.108426-108426, Article 108426

2023

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Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death

Xenobiotica, 2023-05, Vol.53 (5), p.445-453

2023

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Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors

European journal of medicinal chemistry, 2019-04, Vol.167, p.485-498

2019

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Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway

Oncotarget, 2018-01, Vol.9 (1), p.152-166

2018

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Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway

Cellular signalling, 2018-10, Vol.50, p.131-141

2018

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Discovery of indazole inhibitors for heat shock protein 90 as anti-cancer agents

European journal of medicinal chemistry, 2024-10, Vol.276, p.116620, Article 116620

2024

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Deguelin inhibits HCV replication through suppressing cellular autophagy via down regulation of Beclin1 expression in human hepatoma cells

Antiviral research, 2020-02, Vol.174, p.104704-104704, Article 104704

2020

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Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90)

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127374-127374, Article 127374

2020

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Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway

Computational toxicology, 2020-05, Vol.14, p.100123, Article 100123

2020

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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Pharmacological research, 2021-04, Vol.166, p.105487-105487, Article 105487

2021

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Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Cancer, 2019-06, Vol.125 (11), p.1789-1798

2019

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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Cell reports (Cambridge), 2018-04, Vol.23 (1), p.58-67

2018

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Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis

Oncotarget, 2017-05, Vol.8 (20), p.32586-32599

2017

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A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Theranostics, 2022, Vol.12 (1), p.105-125

2022

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Pharmacological basis and new insights of deguelin concerning its anticancer effects

Pharmacological research, 2021-12, Vol.174, p.105935-105935, Article 105935

2021

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Novel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation

Molecular diversity, 2022-08, Vol.26 (4), p.2295-2309

2022

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Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin

International journal of molecular sciences, 2017-02, Vol.18 (2), p.370-370

2017

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Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

International journal of molecular medicine, 2018-06, Vol.41 (6), p.3157-3166

2018

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Recent advances in flavonoid compounds for the treatment of prostate cancer

Molecular biology reports, 2024-12, Vol.51 (1), p.653-653, Article 653

2024

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Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

Journal of cellular and molecular medicine, 2018-12, Vol.22 (12), p.6213-6227

2018

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Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer

Clinical cancer research, 2018-06, Vol.24 (12), p.2828-2843

2018

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Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway

Cancer management and research, 2024-01, Vol.16, p.507-525

2024

Volltextzugriff (PDF)

Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1370-1381

2019

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Discovery of deguelin derivatives in combination with fluconazole against drug-resistant Candida albicans

Medicinal chemistry research, 2023-10, Vol.32 (10), p.2196-2207

2023

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Deguelin inhibits the glioblastoma progression through suppressing CCL2/NFκB signaling pathway

The natural flavonoid compound deguelin suppresses sperm (Sus Scrofa) functions through abnormal activation of the PI3K/AKT pathway

Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors

Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway

Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway

Discovery of indazole inhibitors for heat shock protein 90 as anti-cancer agents

Deguelin inhibits HCV replication through suppressing cellular autophagy via down regulation of Beclin1 expression in human hepatoma cells

Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90)

Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Pharmacological basis and new insights of deguelin concerning its anticancer effects

Novel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation

Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin

Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

Recent advances in flavonoid compounds for the treatment of prostate cancer

Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer

Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway

Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents

Discovery of deguelin derivatives in combination with fluconazole against drug-resistant Candida albicans

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