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Metforminium 5-fluorouracilate: The first codrug molecular salt of 5-fluorouracil demonstrating perfected in vitro/vivo characteristics and synergic antitumor effects

Journal of molecular structure, 2024-07, Vol.1308, p.138084, Article 138084

2024

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Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition

European journal of pharmaceutical sciences, 2021-04, Vol.159, p.105731, Article 105731

2021

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Recent advances in combretastatin A-4 codrugs for cancer therapy

European journal of medicinal chemistry, 2022-11, Vol.241, p.114660-114660, Article 114660

2022

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Preparation and Evaluation of Colon-Targeted Prodrugs of the Microbial Metabolite 3‑Indolepropionic Acid as an Anticolitic Agent

Molecular pharmaceutics, 2021-04, Vol.18 (4), p.1730-1741

2021

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Colchicine prodrugs and codrugs: Chemistry and bioactivities

European journal of medicinal chemistry, 2018-01, Vol.144, p.229-242

2018

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5‑Aminosalicylic Acid Azo-Coupled with a GPR109A Agonist Is a Colon-Targeted Anticolitic Codrug with a Reduced Risk of Skin Toxicity

Molecular pharmaceutics, 2020-01, Vol.17 (1), p.167-179

2020

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H2S Donors with Cytoprotective Effects in Models of MI/R Injury and Chemotherapy-Induced Cardiotoxicity

Antioxidants, 2023-03, Vol.12 (3), p.650

2023

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The codrug approach for facilitating drug delivery and bioactivity

Expert opinion on drug delivery, 2016-09, Vol.13 (9), p.1311-1325

2016

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Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review

International Journal of Molecular Sciences, 2012-12, Vol.13 (12), p.17244-17274

Qandil, Amjad M

2012

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Solid lipid nanoparticles loaded with lipoyl–memantine codrug: Preparation and characterization

International journal of pharmaceutics, 2015-05, Vol.485 (1-2), p.183-191

2015

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Molecular Consortia-Various Structural and Synthetic Concepts for More Effective Therapeutics Synthesis

International journal of molecular sciences, 2018-04, Vol.19 (4), p.1104

2018

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Synthesis of 125I-lamivudine and 125I-lamivudine-ursodeoxycholic acid codrug

Journal of labelled compounds & radiopharmaceuticals, 2016-09, Vol.59 (11), p.451-453

2016

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Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities

ACS infectious diseases, 2019-07, Vol.5 (7), p.1239-1251

2019

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Interconvertible Hydrochlorothiazide–Caffeine Multicomponent Pharmaceutical Materials: A Solvent Issue

Crystals (Basel), 2020-12, Vol.10 (12), p.1088

2020

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α‑Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis

ACS medicinal chemistry letters, 2020-12, Vol.11 (12), p.2406-2413

2020

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Codrug: An efficient approach for drug optimization

European journal of pharmaceutical sciences, 2010-12, Vol.41 (5), p.571-588

2010

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Mutual Prodrugs - Codrugs

Current medicinal chemistry, 2023-01, Vol.30 (38), p.4283

Nudelman, Abraham

2023

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Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti‐inflammatory drugs: Synthesis, kinetic and pharmacological evaluation

Archiv der Pharmazie (Weinheim), 2019-07, Vol.352 (7), p.e1800339-n/a

2019

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Development of 5-fluorouracil-dichloroacetate mutual prodrugs as anticancer agents

Bioorganic chemistry, 2023-11, Vol.140, p.106784-106784, Article 106784

2023

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Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation

European journal of pharmaceutics and biopharmaceutics, 2017-05, Vol.114, p.154-163

2017

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Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid

Future medicinal chemistry, 2023-05, Vol.15 (9), p.735-743

2023

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The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors

Viruses, 2023-11, Vol.15 (11), p.2234

2023

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Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer

ACS medicinal chemistry letters, 2020-03, Vol.11 (3), p.316-321

2020

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From Combinations to Single-Molecule Polypharmacology-Cromolyn-Ibuprofen Conjugates for Alzheimer's Disease

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.1112

2021

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Synthesis and Evaluation of Amide Codrug of Ibuprofen and Amlodipine for Dual Inhibition of Inflammation and Hypertension

Research journal of pharmacy and technology, 2023-08, Vol.16 (8), p.3957-3963

2023

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Metforminium 5-fluorouracilate: The first codrug molecular salt of 5-fluorouracil demonstrating perfected in vitro/vivo characteristics and synergic antitumor effects

Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition

Recent advances in combretastatin A-4 codrugs for cancer therapy

Preparation and Evaluation of Colon-Targeted Prodrugs of the Microbial Metabolite 3‑Indolepropionic Acid as an Anticolitic Agent

Colchicine prodrugs and codrugs: Chemistry and bioactivities

5‑Aminosalicylic Acid Azo-Coupled with a GPR109A Agonist Is a Colon-Targeted Anticolitic Codrug with a Reduced Risk of Skin Toxicity

H2S Donors with Cytoprotective Effects in Models of MI/R Injury and Chemotherapy-Induced Cardiotoxicity

The codrug approach for facilitating drug delivery and bioactivity

Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review

Solid lipid nanoparticles loaded with lipoyl–memantine codrug: Preparation and characterization

Molecular Consortia-Various Structural and Synthetic Concepts for More Effective Therapeutics Synthesis

Synthesis of 125I-lamivudine and 125I-lamivudine-ursodeoxycholic acid codrug

Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities

Interconvertible Hydrochlorothiazide–Caffeine Multicomponent Pharmaceutical Materials: A Solvent Issue

α‑Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis

Codrug: An efficient approach for drug optimization

Mutual Prodrugs - Codrugs

Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti‐inflammatory drugs: Synthesis, kinetic and pharmacological evaluation

Development of 5-fluorouracil-dichloroacetate mutual prodrugs as anticancer agents

Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation

Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid

The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors

Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer

From Combinations to Single-Molecule Polypharmacology-Cromolyn-Ibuprofen Conjugates for Alzheimer's Disease

Synthesis and Evaluation of Amide Codrug of Ibuprofen and Amlodipine for Dual Inhibition of Inflammation and Hypertension

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