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Retinal pigment epithelium 65 kDa protein (RPE65): An update

Progress in retinal and eye research, 2022-05, Vol.88, p.101013-101013, Article 101013

Kiser, Philip D.

2022

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Rational Tuning of Visual Cycle Modulator Pharmacodynamics

The Journal of pharmacology and experimental therapeutics, 2017-07, Vol.362 (1), p.131-145

2017

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Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy

Molecular therapy, 2021-02, Vol.29 (2), p.442-463

2021

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Luxturna: FDA documents reveal the value of a costly gene therapy

Drug discovery today, 2019-04, Vol.24 (4), p.949-954

Darrow, Jonathan J.

2019

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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Nature chemical biology, 2024-06, Vol.20 (6), p.779-788

2024

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Functional Characterization of a CruP-Like Isomerase in Dunaliella

Journal of agricultural and food chemistry, 2024-05, Vol.72 (17), p.10005-10013

2024

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Chemistry of the Retinoid (Visual) Cycle

Chemical reviews, 2014-01, Vol.114 (1), p.194-232

2014

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Cost Utility of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease

Value in health, 2019-02, Vol.22 (2), p.161-167

2019

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Control of carotenoid biosynthesis through a heme-based cis-trans isomerase

Nature chemical biology, 2015-08, Vol.11 (8), p.598-605

2015

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AAV2 gene therapy readministration in three adults with congenital blindness

Science translational medicine, 2012-02, Vol.4 (120), p.120ra15

2012

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Biochemical characterization and selective inhibition of β‐carotene cis–trans isomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway

The FEBS journal, 2015-10, Vol.282 (20), p.3986-4000

2015

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Membrane engineering via trans unsaturated fatty acids production improves Escherichia coli robustness and production of biorenewables

Metabolic engineering, 2016-05, Vol.35, p.105-113

2016

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Gene Therapy for Retinal Degeneration

Cell, 2018-03, Vol.173 (1), p.5-5

Apte, Rajendra S.

2018

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Molecular pharmacodynamics of emixustat in protection against retinal degeneration

The Journal of clinical investigation, 2015-07, Vol.125 (7), p.2781-2794

2015

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Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide

Experimental eye research, 2019-02, Vol.179, p.18-24

2019

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Comparative efficacy of selenate and selenium nanoparticles for improving growth, productivity, fruit quality, and postharvest longevity through modifying nutrition, metabolism, and gene expression in tomato; potential benefits and risk assessment

PloS one, 2020-12, Vol.15 (12), p.e0244207

2020

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HIGH-TILLERING AND DWARF 12 modulates photosynthesis and plant architecture by affecting carotenoid biosynthesis in rice

Journal of experimental botany, 2021-02, Vol.72 (4), p.1212-1224

2021

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The Arabidopsis D27‐LIKE1 is a cis/cis/trans‐β‐carotene isomerase that contributes to Strigolactone biosynthesis and negatively impacts ABA level

The Plant journal : for cell and molecular biology, 2023-03, Vol.113 (5), p.986-1003

2023

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Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism

The Journal of biological chemistry, 2016-03, Vol.291 (10), p.4966-4973

2016

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Transcriptional regulation of fatty acid cis–trans isomerization in the solvent‐tolerant soil bacterium, Pseudomonas putida F1

Environmental microbiology, 2019-05, Vol.21 (5), p.1659-1676

2019

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Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity

PloS one, 2015-05, Vol.10 (5), p.e0124940-e0124940

2015

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Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials

Ophthalmology (Rochester, Minn.), 2019-09, Vol.126 (9), p.1273-1285

2019

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Pharmacotherapy of retinal disease with visual cycle modulators

Expert opinion on pharmacotherapy, 2018-03, Vol.19 (5), p.471-481

2018

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A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration

Biochimica et biophysica acta. Molecular basis of disease, 2018-07, Vol.1864 (7), p.2420-2429

2018

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An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of h RPE65

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2162047

2023

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Retinal pigment epithelium 65 kDa protein (RPE65): An update

Rational Tuning of Visual Cycle Modulator Pharmacodynamics

Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy

Luxturna: FDA documents reveal the value of a costly gene therapy

Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Functional Characterization of a CruP-Like Isomerase in Dunaliella

Chemistry of the Retinoid (Visual) Cycle

Cost Utility of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease

Control of carotenoid biosynthesis through a heme-based cis-trans isomerase

AAV2 gene therapy readministration in three adults with congenital blindness

Biochemical characterization and selective inhibition of β‐carotene cis–trans isomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway

Membrane engineering via trans unsaturated fatty acids production improves Escherichia coli robustness and production of biorenewables

Gene Therapy for Retinal Degeneration

Molecular pharmacodynamics of emixustat in protection against retinal degeneration

Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide

Comparative efficacy of selenate and selenium nanoparticles for improving growth, productivity, fruit quality, and postharvest longevity through modifying nutrition, metabolism, and gene expression in tomato; potential benefits and risk assessment

HIGH-TILLERING AND DWARF 12 modulates photosynthesis and plant architecture by affecting carotenoid biosynthesis in rice

The Arabidopsis D27‐LIKE1 is a cis/cis/trans‐β‐carotene isomerase that contributes to Strigolactone biosynthesis and negatively impacts ABA level

Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism

Transcriptional regulation of fatty acid cis–trans isomerization in the solvent‐tolerant soil bacterium, Pseudomonas putida F1

Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity

Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials

Pharmacotherapy of retinal disease with visual cycle modulators

A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration

An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of h RPE65

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