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Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

The Journal of biological chemistry, 2019-01, Vol.294 (2), p.697-707

2019

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Therapeutic targeting of cathepsin C: from pathophysiology to treatment

Pharmacology & therapeutics (Oxford), 2018-10, Vol.190, p.202-236

2018

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Cathepsin C inhibition as a potential treatment strategy in cancer

Biochemical pharmacology, 2021-12, Vol.194, p.114803, Article 114803

2021

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Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

Genes & development, 2013-10, Vol.27 (19), p.2086-2098

2013

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Cathepsin C in health and disease: from structural insights to therapeutic prospects

Journal of translational medicine, 2024-08, Vol.22 (1), p.777-25

2024

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Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion

Neurochemistry international, 2021-09, Vol.148, p.105107-105107, Article 105107

2021

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Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

Biochemical pharmacology, 2019-06, Vol.164, p.349-367

2019

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Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660)

British journal of clinical pharmacology, 2017-12, Vol.83 (12), p.2813-2820

2017

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Cystatin F Depletion in Mycobacterium tuberculosis -Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection

International journal of molecular sciences, 2024-08, Vol.25 (15), p.8141

2024

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Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I

Archives of biochemistry and biophysics, 2019-10, Vol.675, p.108121-108121, Article 108121

2019

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Cysteine Cathepsins and the Cutting Edge of Cancer Invasion

Cell cycle (Georgetown, Tex.), 2007-01, Vol.6 (1), p.60-64

2007

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A cathepsin C-like protease mediates the post-translation modification of Toxoplasma gondii secretory proteins for optimal invasion and egress

mBio, 2023-08, Vol.14 (4), p.e0017423-e0017423

2023

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Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

The Journal of clinical investigation, 2002-02, Vol.109 (3), p.363-371

2002

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CTSC compound heterozygous mutations in two Chinese patients with Papillon–Lefèvre syndrome

Oral diseases, 2019-07, Vol.25 (5), p.1394-1402

2019

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Evolutionary Analysis of Dipeptidyl Peptidase I

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1852

2022

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Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors

Journal of medicinal chemistry, 2019-06, Vol.62 (12), p.5901-5919

2019

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Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells

Cellular signalling, 2018-06, Vol.46, p.92-102

2018

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CTSC promoted the migration and invasion of glioma cells via activation of STAT3/SERPINA3 axis

Gene, 2024-01, Vol.893, p.147948-147948, Article 147948

2024

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Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation

Arteriosclerosis, thrombosis, and vascular biology, 2016-08, Vol.36 (8), p.1660-1669

2016

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Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis

Toxicology letters, 2024-04, Vol.394, p.102-113

2024

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Processing of human protryptase in mast cells involves cathepsins L, B, and C

The Journal of immunology (1950), 2011-08, Vol.187 (4), p.1912-1918

2011

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A rare CTSC mutation in Papillon-Lefèvre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function

PloS one, 2021-12, Vol.16 (12), p.e0261724-e0261724

2021

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Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury

Redox biology, 2024-08, Vol.74, p.103231, Article 103231

2024

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Effects of Five Substances with Different Modes of Action on Cathepsin H, C and L Activities in Zebrafish Embryos

International journal of environmental research and public health, 2019-10, Vol.16 (20), p.3956

2019

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Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9457-9472

2016

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Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

Cathepsin C inhibition as a potential treatment strategy in cancer

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

Cathepsin C in health and disease: from structural insights to therapeutic prospects

Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660)

Cystatin F Depletion in Mycobacterium tuberculosis -Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection

Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I

Cysteine Cathepsins and the Cutting Edge of Cancer Invasion

A cathepsin C-like protease mediates the post-translation modification of Toxoplasma gondii secretory proteins for optimal invasion and egress

Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

CTSC compound heterozygous mutations in two Chinese patients with Papillon–Lefèvre syndrome

Evolutionary Analysis of Dipeptidyl Peptidase I

Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors

Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells

CTSC promoted the migration and invasion of glioma cells via activation of STAT3/SERPINA3 axis

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation

Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis

Processing of human protryptase in mast cells involves cathepsins L, B, and C

A rare CTSC mutation in Papillon-Lefèvre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function

Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury

Effects of Five Substances with Different Modes of Action on Cathepsin H, C and L Activities in Zebrafish Embryos

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

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