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Development and validation of HPTLC and green HPLC methods for determination of furosemide, spironolactone and canrenone, in pure forms, tablets and spiked human plasma

Biomedical chromatography, 2018-10, Vol.32 (10), p.e4304-n/a

2018

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Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease

Cochrane database of systematic reviews, 2020-10, Vol.10 (10), p.CD007004

2020

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Stability‐indicating analytical method of quantifying spironolactone and canrenone in dermatological formulations and iontophoretic skin permeation experiments

Biomedical chromatography, 2019-11, Vol.33 (11), p.e4656-n/a

2019

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Successive ratio subtraction as a novel manipulation of ratio spectra for quantitative determination of a mixture of furosemide, spironolactone and canrenone

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2018-03, Vol.192, p.427-436

2018

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Simultaneous separation and rapid determination of spironolactone and its metabolite canrenone in different pharmaceutical formulations and urinary matrices by capillary zone electrophoresis

Journal of separation science, 2016-07, Vol.39 (14), p.2869-2875

2016

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Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives

Steroids, 2017-02, Vol.118, p.76-92

2017

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Mineralocorticoid Receptor Antagonist Effect on Aldosterone to Renin Ratio in Patients With Primary Aldosteronism

The journal of clinical endocrinology and metabolism, 2021-09, Vol.106 (9), p.e3655-e3664

2021

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Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay

Clinical biochemistry, 2024-04, Vol.126, p.110747-110747, Article 110747

2024

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Spironolactone Metabolites in TOPCAT — New Insights into Regional Variation

The New England journal of medicine, 2017-04, Vol.376 (17), p.1690-1692

2017

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Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus

Acta Pharmaceutica, 2021-03, Vol.71 (1), p.99-114

2021

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Aldosterone receptor blockers spironolactone and canrenone: two multivalent drugs

Expert opinion on pharmacotherapy, 2014-05, Vol.15 (7), p.909-912

2014

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Canrenone on cardiovascular mortality in congestive heart failure

Pharmacological research, 2019-03, Vol.141, p.46-52

2019

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Development of a high-yielding bioprocess for 11-α hydroxylation of canrenone under conditions of oxygen-enriched air supply

Steroids, 2016-12, Vol.116, p.1-4

2016

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Eplerenone Is Not Superior to Older and Less Expensive Aldosterone Antagonists

The American journal of medicine, 2012-08, Vol.125 (8), p.817-825

2012

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The human adrenal gland as a drug metabolizer: First in-vivo evidence for the conversion of steroidal drugs

The Journal of steroid biochemistry and molecular biology, 2019-11, Vol.194, p.105438, Article 105438

2019

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Effects of Impeller Geometry on the 11α-Hydroxylation of Canrenone in Rushton Turbine-Stirred Tanks

Journal of Microbiology and Biotechnology, 2021, 31(6), , pp.890-901

2021

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The influence of the configurations of multiple-impeller on canrenone bioconversion using resting cells of Aspergillus ochraceus

International journal of chemical reactor engineering, 2023-09, Vol.21 (9), p.1131-1140

2023

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Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment

Journal of endocrinological investigation, 2021-09, Vol.44 (9), p.2009-2010

2021

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Endogenous bufadienolides, mineralocorticoid receptor antagonists and fibrosis in chronic kidney disease

Frontiers in pharmacology, 2024-09, Vol.15, p.1431216

2024

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Reliable and easy-to-use LC–MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension

Journal of pharmaceutical and biomedical analysis, 2019-02, Vol.164, p.373-381

2019

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Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs

PloS one, 2024-02, Vol.19 (2), p.e0298030-e0298030

2024

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Effects of Mineralocorticoid and AT1 Receptor Antagonism on The Aldosterone-Renin Ratio In Primary Aldosteronism—the EMIRA Study

The journal of clinical endocrinology and metabolism, 2020-06, Vol.105 (6), p.2060-2067

2020

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Canrenone on cardiovascular mortality in congestive heart failure: CanrenOne eFFects on cardiovascular mortality in patiEnts with congEstIve hearT failure: The COFFEE-IT study

Pharmacological research, 2019-03, Vol.141, p.46-52

2019

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Underestimated reactions and regulation patterns of adrenal cytochromes P450

Molecular and cellular endocrinology, 2021-06, Vol.530, p.111237, Article 111237

2021

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Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions

Clinical pharmacokinetics, 2023-07, Vol.62 (7), p.1031-1041

2023

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Development and validation of HPTLC and green HPLC methods for determination of furosemide, spironolactone and canrenone, in pure forms, tablets and spiked human plasma

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease

Stability‐indicating analytical method of quantifying spironolactone and canrenone in dermatological formulations and iontophoretic skin permeation experiments

Successive ratio subtraction as a novel manipulation of ratio spectra for quantitative determination of a mixture of furosemide, spironolactone and canrenone

Simultaneous separation and rapid determination of spironolactone and its metabolite canrenone in different pharmaceutical formulations and urinary matrices by capillary zone electrophoresis

Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives

Mineralocorticoid Receptor Antagonist Effect on Aldosterone to Renin Ratio in Patients With Primary Aldosteronism

Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay

Spironolactone Metabolites in TOPCAT — New Insights into Regional Variation

Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus

Aldosterone receptor blockers spironolactone and canrenone: two multivalent drugs

Canrenone on cardiovascular mortality in congestive heart failure

Development of a high-yielding bioprocess for 11-α hydroxylation of canrenone under conditions of oxygen-enriched air supply

Eplerenone Is Not Superior to Older and Less Expensive Aldosterone Antagonists

The human adrenal gland as a drug metabolizer: First in-vivo evidence for the conversion of steroidal drugs

Effects of Impeller Geometry on the 11α-Hydroxylation of Canrenone in Rushton Turbine-Stirred Tanks

The influence of the configurations of multiple-impeller on canrenone bioconversion using resting cells of Aspergillus ochraceus

Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment

Endogenous bufadienolides, mineralocorticoid receptor antagonists and fibrosis in chronic kidney disease

Reliable and easy-to-use LC–MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension

Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs

Effects of Mineralocorticoid and AT1 Receptor Antagonism on The Aldosterone-Renin Ratio In Primary Aldosteronism—the EMIRA Study

Canrenone on cardiovascular mortality in congestive heart failure: CanrenOne eFFects on cardiovascular mortality in patiEnts with congEstIve hearT failure: The COFFEE-IT study

Underestimated reactions and regulation patterns of adrenal cytochromes P450

Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions

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