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Novel bexarotene derivatives: Synthesis and cytotoxicity evaluation for glioma cells in 2D and 3D in vitro models

European journal of pharmacology, 2020-09, Vol.883, p.173346, Article 173346

2020

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Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

Journal of controlled release, 2018-09, Vol.286, p.10-19

2018

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A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022-01, Vol.1189, p.123025-123025, Article 123025

2022

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Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Pharmacological research, 2020-09, Vol.159, p.104960-104960, Article 104960

2020

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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Nature communications, 2021-01, Vol.12 (1), p.688-9, Article 688

2021

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Bexarotene enhances astrocyte phagocytosis via ABCA1-mediated pathways in a mouse model of subarachnoid hemorrhage

Experimental neurology, 2022-12, Vol.358, p.114228, Article 114228

2022

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Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

Neurobiology of disease, 2018-09, Vol.117, p.114-124

2018

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Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage

Stroke (1970), 2020-02, Vol.51 (2), p.612-618

2020

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Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

The New England journal of medicine, 2017-07, Vol.377 (1), p.62-70

2017

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Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Experimental neurology, 2019-04, Vol.314, p.111-125

2019

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Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer

Pharmacology & therapeutics (Oxford), 2023-12, Vol.252, p.108561-108561, Article 108561

2023

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Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

Molecular neurobiology, 2018-12, Vol.55 (12), p.9043-9056

2018

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Effects of Body Mass Index on Hypertriglyceridemia Associated with Oral Bexarotene Therapy: A Post Hoc Analysis of an Open-Label Comparative Clinical Study of Combined Bexarotene and Phototherapy Versus Bexarotene Monotherapy for Japanese Patients with Cutaneous T-Cell Lymphoma

Drugs in R&D, 2024-06, Vol.24 (2), p.227-238

2024

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Synthesis of some steroidal mitocans of nanomolar cytotoxicity acting by apoptosis

European journal of medicinal chemistry, 2020-08, Vol.199, p.112425, Article 112425

2020

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GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells

Oncotarget, 2024-02, Vol.15 (1), p.124-133

2024

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Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

BMC cancer, 2018-04, Vol.18 (1), p.407-407, Article 407

2018

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Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

Neurochemical research, 2020-07, Vol.45 (7), p.1500-1509

2020

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Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

Journal of pharmaceutical sciences, 2019-02, Vol.108 (2), p.1047-1052

2019

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Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice

Nano letters, 2019-04, Vol.19 (4), p.2231-2242

2019

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Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

Journal of neuroinflammation, 2019-02, Vol.16 (1), p.47-47, Article 47

2019

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Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells

Molecular neurobiology, 2019-12, Vol.56 (12), p.8220-8236

2019

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The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2023-07, Vol.1868 (7), p.159329-159329, Article 159329

2023

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Novel bexarotene derivatives: Synthesis and cytotoxicity evaluation for glioma cells in 2D and 3D in vitro models

Bexarotene-induced hypothyroidism and dyslipidemia; a nation-wide study

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Bexarotene enhances astrocyte phagocytosis via ABCA1-mediated pathways in a mouse model of subarachnoid hemorrhage

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer

Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

Effects of Body Mass Index on Hypertriglyceridemia Associated with Oral Bexarotene Therapy: A Post Hoc Analysis of an Open-Label Comparative Clinical Study of Combined Bexarotene and Phototherapy Versus Bexarotene Monotherapy for Japanese Patients with Cutaneous T-Cell Lymphoma

Synthesis of some steroidal mitocans of nanomolar cytotoxicity acting by apoptosis

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells

Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes

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