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Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity

International journal of molecular sciences, 2018-02, Vol.19 (2), p.476

2018

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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Nature genetics, 2019-11, Vol.51 (11), p.1596-1606

2019

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Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

eLife, 2020-07, Vol.9

2020

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SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity

The Journal of biological chemistry, 2019-02, Vol.294 (6), p.1860-1876

2019

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Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years

The journal of clinical endocrinology and metabolism, 2020-12, Vol.105 (12), p.1-e4651

2020

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Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (32), p.E7642-E7649

2018

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Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer

Cancer science, 2018-09, Vol.109 (9), p.2946-2956

2018

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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells

Journal of Immunology Research, 2018-01, Vol.2018 (2018), p.1-9

2018

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The C‐terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant

The FEBS journal, 2018-04, Vol.285 (7), p.1237-1250

2018

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Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions

International journal of molecular sciences, 2021-03, Vol.22 (6), p.2940

2021

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Development of a Plasma Zinc Concentration Cutoff to Identify Individuals with Severe Zinc Deficiency Based on Results from Adults Undergoing Experimental Severe Dietary Zinc Restriction and Individuals with Acrodermatitis Enteropathica

The Journal of nutrition, 2014-08, Vol.144 (8), p.1204-1210

2014

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Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (38), p.10196-10201

2017

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Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

Diabetes (New York, N.Y.), 2021-04, Vol.70 (4), p.932-943

2021

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The Protective Role of Glutathione on Zinc-Induced Neuron Death after Brain Injuries

International journal of molecular sciences, 2023-02, Vol.24 (3), p.2950

2023

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Insights into the structure-function relationship of both wild and mutant zinc transporter ZnT8 in human: a computational structural biology approach

Journal of biomolecular structure & dynamics, 2020-01, Vol.38 (1), p.137-151

2020

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Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel

Scientific reports, 2017-03, Vol.7 (1), p.473-10, Article 473

2017

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Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus

Stem cells (Dayton, Ohio), 2020-08, Vol.38 (8), p.994-1006

2020

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Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10, a Manganese Transporter in Man

American journal of human genetics, 2012-03, Vol.90 (3), p.457-466

2012

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Distribution of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8 in type 1 diabetes and latent autoimmune diabetes: A nationwide, multicentre, cross‐sectional study

Diabetes/metabolism research and reviews, 2023-02, Vol.39 (2), p.e3592-n/a

2023

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Relationship Between the Single Nucleotide Polymorphism rs11558471 in the SLC30A8/ZnT8 Gene and Cardiometabolic Markers in Postmenopausal Women

Biological trace element research, 2023-05, Vol.201 (5), p.2183-2190

2023

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Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study

Diabetes care, 2020-09, Vol.43 (9), p.2066-2073

2020

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TIGER: The gene expression regulatory variation landscape of human pancreatic islets

Cell reports (Cambridge), 2021-10, Vol.37 (2), p.109807-109807, Article 109807

2021

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Multiple genetic variants at the SLC30A8 locus affect local super‐enhancer activity and influence pancreatic β‐cell survival and function

The FASEB journal, 2024-04, Vol.38 (8), p.e23610-n/a

2024

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A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells

The Journal of biological chemistry, 2018-01, Vol.293 (2), p.579-587

2018

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The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells

Scientific reports, 2019-06, Vol.9 (1), p.8589-15, Article 8589

2019

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Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity

Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells

The C‐terminal cytosolic domain of the human zinc transporter ZnT8 and its diabetes risk variant

Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions

Development of a Plasma Zinc Concentration Cutoff to Identify Individuals with Severe Zinc Deficiency Based on Results from Adults Undergoing Experimental Severe Dietary Zinc Restriction and Individuals with Acrodermatitis Enteropathica

Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform

Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis

The Protective Role of Glutathione on Zinc-Induced Neuron Death after Brain Injuries

Insights into the structure-function relationship of both wild and mutant zinc transporter ZnT8 in human: a computational structural biology approach

Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel

Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10, a Manganese Transporter in Man

Distribution of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8 in type 1 diabetes and latent autoimmune diabetes: A nationwide, multicentre, cross‐sectional study

Relationship Between the Single Nucleotide Polymorphism rs11558471 in the SLC30A8/ZnT8 Gene and Cardiometabolic Markers in Postmenopausal Women

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

Multiple genetic variants at the SLC30A8 locus affect local super‐enhancer activity and influence pancreatic β‐cell survival and function

A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells

The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells

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