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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Scientific reports, 2024-09, Vol.14 (1), p.20824-16, Article 20824

2024

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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Nature (London), 2024-05, Vol.629 (8011), p.435-442

2024

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Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024)

ChemMedChem, 2024-04, Vol.19 (8), p.n/a

2024

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Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors

ChemMedChem, 2024-04, Vol.19 (8), p.e202300613-n/a

2024

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The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome

Endocrine, 2024-04, Vol.84 (1), p.92-96

2024

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WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases

Genes & development, 2024-03, Vol.38 (5-6), p.213-232

2024

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WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

Cell & bioscience, 2024-01, Vol.14 (1), p.7-7, Article 7

2024

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Early‐onset diabetes mellitus as a presenting feature of Werner's syndrome in an Indian family

Molecular genetics & genomic medicine, 2024-01, Vol.12 (1), p.e2299-n/a

2024

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Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR

Genes & development, 2023-10, Vol.37 (19-20), p.913-928

2023

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Structural characterization of human RPA70N association with DNA damage response proteins

eLife, 2023-09, Vol.12

2023

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Lynch-like syndrome with germline WRN mutation in Bulgarian patient with synchronous endometrial and ovarian cancer

Hereditary cancer in clinical practice, 2023-07, Vol.21 (1), p.13-13, Article 13

2023

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Combination of untargeted and targeted proteomics for secretome analysis of L-WRN cells

Analytical and bioanalytical chemistry, 2023-03, Vol.415 (8), p.1465-1476

2023

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A homozygous missense variant in the WRN gene segregating in a family with progressive pulmonary failure with recurrent spontaneous pneumothorax and interstitial lung disease

American journal of medical genetics. Part A, 2023-01, Vol.191 (1), p.220-227

2023

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Resistance to DNA repair inhibitors in cancer

Molecular oncology, 2022-11, Vol.16 (21), p.3811-3827

2022

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WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer

BioEssays, 2022-08, Vol.44 (8), p.e2200057-n/a

2022

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SHP2's gain‐of‐function in Werner syndrome causes childhood disease onset likely resulting from negative genetic interaction

Clinical genetics, 2022-07, Vol.102 (1), p.12-21

2022

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Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer

Aging cell, 2022-06, Vol.21 (6), p.e13625-n/a

2022

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Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Journal of clinical laboratory analysis, 2022-04, Vol.36 (4), p.e24321-n/a

2022

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Targeting of RecQ Helicases as a Novel Therapeutic Strategy for Ovarian Cancer

Cancers, 2022-02, Vol.14 (5), p.1219

2022

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Prognostic Implications of Six Altered Genes in Asian Non-Surgical Esophageal Carcinoma Patients Treated with Chemoradiotherapy

OncoTargets and therapy, 2022-01, Vol.15, p.41-51

2022

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Exacerbated Renal and Hematologic Toxicities to Ifosfamide and Doxorubicin-Based Chemotherapy in a Patient with Retroperitoneal Liposarcoma Harboring a Germline Mutation in the WRN Gene

Case reports in oncology, 2022-01, Vol.15 (1), p.170-175

2022

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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice

Aging cell, 2021-11, Vol.20 (11), p.e13484-n/a

2021

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Checkpoint functions of RecQ helicases at perturbed DNA replication fork

Current genetics, 2021-06, Vol.67 (3), p.369-382

2021

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Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Scientific reports, 2021-04, Vol.11 (1), p.9122-9122, Article 9122

2021

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The Impact of Vitamin C on Different System Models of Werner Syndrome

Antioxidants & redox signaling, 2021-04, Vol.34 (11), p.856-874

2021

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024)

Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors

The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome

WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases

WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

Early‐onset diabetes mellitus as a presenting feature of Werner's syndrome in an Indian family

Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR

Structural characterization of human RPA70N association with DNA damage response proteins

Lynch-like syndrome with germline WRN mutation in Bulgarian patient with synchronous endometrial and ovarian cancer

Combination of untargeted and targeted proteomics for secretome analysis of L-WRN cells

A homozygous missense variant in the WRN gene segregating in a family with progressive pulmonary failure with recurrent spontaneous pneumothorax and interstitial lung disease

Resistance to DNA repair inhibitors in cancer

WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer

SHP2's gain‐of‐function in Werner syndrome causes childhood disease onset likely resulting from negative genetic interaction

Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer

Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Targeting of RecQ Helicases as a Novel Therapeutic Strategy for Ovarian Cancer

Prognostic Implications of Six Altered Genes in Asian Non-Surgical Esophageal Carcinoma Patients Treated with Chemoradiotherapy

Exacerbated Renal and Hematologic Toxicities to Ifosfamide and Doxorubicin-Based Chemotherapy in a Patient with Retroperitoneal Liposarcoma Harboring a Germline Mutation in the WRN Gene

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice

Checkpoint functions of RecQ helicases at perturbed DNA replication fork

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

The Impact of Vitamin C on Different System Models of Werner Syndrome

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