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Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024)

ChemMedChem, 2024-04, Vol.19 (8), p.n/a

2024

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WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases

Genes & development, 2024-04, Vol.38 (5-6), p.213

2024

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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Nature (London), 2024-05, Vol.629 (8011), p.435-442

2024

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The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome

Endocrine, 2024-04, Vol.84 (1), p.92-96

2024

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MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner

Oncogene, 2019-04, Vol.38 (14), p.2501-2515

2019

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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice

Aging cell, 2021-11, Vol.20 (11), p.e13484-n/a

2021

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A homozygous missense variant in the WRN gene segregating in a family with progressive pulmonary failure with recurrent spontaneous pneumothorax and interstitial lung disease

American journal of medical genetics. Part A, 2023-01, Vol.191 (1), p.220-227

2023

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Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes

Aging cell, 2019-10, Vol.18 (5), p.e12995-n/a

2019

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Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

The Journal of biological chemistry, 1999-12, Vol.274 (53), p.37538-37543

1999

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Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Scientific reports, 2021-04, Vol.11 (1), p.9122-9122, Article 9122

2021

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Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

Biogerontology (Dordrecht), 2019-06, Vol.20 (3), p.255-269

2019

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Early‐onset diabetes mellitus as a presenting feature of Werner's syndrome in an Indian family

Molecular genetics & genomic medicine, 2024-01, Vol.12 (1), p.e2299-n/a

2024

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The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

Nucleic acids research, 2001-07, Vol.29 (13), p.2843

2001

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The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

Oncogene, 2013-01, Vol.32 (5), p.610-620

2013

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Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

PloS one, 2015-10, Vol.10 (10), p.e0140292-e0140292

2015

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Werner Syndrome Protein (WRN) Regulates Cell Proliferation and the Human Papillomavirus 16 Life Cycle during Epithelial Differentiation

mSphere, 2020-09, Vol.5 (5)

2020

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Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype

Scientific reports, 2017-03, Vol.7 (1), p.44081, Article 44081

2017

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RECQL5 plays co-operative and complementary roles with WRN syndrome helicase

Nucleic acids research, 2013-01, Vol.41 (2), p.881

2013

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The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling

Oncogene, 2012-06, Vol.31 (23), p.2809-2823

2012

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Acetylation of WRN protein regulates its stability by inhibiting ubiquitination

PloS one, 2010-04, Vol.5 (4), p.e10341-e10341

2010

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Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

The EMBO journal, 2001-10, Vol.20 (20), p.5791-5801

2001

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The ophthalmic diagnosis and management of four siblings with Werner syndrome

International ophthalmology, 2019-06, Vol.39 (6), p.1371-1378

2019

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Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks

Molecular & cellular oncology, 2017-01, Vol.4 (1), p.e1268243

2017

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Werner Syndrome Protein Contains Three Structure-specific DNA Binding Domains

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52997-53006

2003

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Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing

The Journal of biological chemistry, 2000-09, Vol.275 (37), p.28349-28352

2000

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Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024)

WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

The identification of a novel mutation (p.I223fs) in WRN associated with Werner syndrome

MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice

A homozygous missense variant in the WRN gene segregating in a family with progressive pulmonary failure with recurrent spontaneous pneumothorax and interstitial lung disease

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

Early‐onset diabetes mellitus as a presenting feature of Werner's syndrome in an Indian family

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Werner Syndrome Protein (WRN) Regulates Cell Proliferation and the Human Papillomavirus 16 Life Cycle during Epithelial Differentiation

Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase

The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling

Acetylation of WRN protein regulates its stability by inhibiting ubiquitination

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

The ophthalmic diagnosis and management of four siblings with Werner syndrome

Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks

Werner Syndrome Protein Contains Three Structure-specific DNA Binding Domains

Functional Interaction between Ku and the Werner Syndrome Protein in DNA End Processing

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