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Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages

The Journal of biological chemistry, 2023-08, Vol.299 (8), p.104984-104984, Article 104984

2023

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SAMHD1 … and Viral Ways around It

Viruses, 2021-03, Vol.13 (3), p.395

2021

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Interference with SAMHD1 Restores Late Gene Expression of Modified Vaccinia Virus Ankara in Human Dendritic Cells and Abrogates Type I Interferon Expression

Journal of virology, 2019-11, Vol.93 (22)

2019

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Enhanced infection efficiency and cytotoxicity mediated by vpx-containing lentivirus in chimeric antigen receptor macrophage (CAR-M)

Heliyon, 2023-12, Vol.9 (12), p.e21886-e21886, Article e21886

2023

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Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage

Frontiers in microbiology, 2016-08, Vol.7, p.1211-1211

2016

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Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

Cell reports (Cambridge), 2019-04, Vol.27 (5), p.1579-1596.e7

2019

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Interaction Between Vpx and SAMHD1 , Vital for SAMHD1 Inhibition

AIDS research and human retroviruses, 2024-06, Vol.40 (6), p.384

2024

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Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection

Molecular therapy, 2020-08, Vol.28 (8), p.1795-1805

2020

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Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells

Cell reports (Cambridge), 2024-03, Vol.43 (3), p.113941-113941, Article 113941

2024

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HUSH, a Link Between Intrinsic Immunity and HIV Latency

Frontiers in microbiology, 2019-02, Vol.10, p.224-224

2019

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Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy

Human gene therapy, 2017-02, Vol.28 (2), p.200-215

2017

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Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation

Virology (New York, N.Y.), 2019-11, Vol.537, p.36-44

2019

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SAMHD1 protects cancer cells from various nucleoside-based antimetabolites

Cell cycle (Georgetown, Tex.), 2017-06, Vol.16 (11), p.1029-1038

2017

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Purified recombinant lentiviral Vpx proteins maintain their SAMHD1 degradation efficiency in resting CD4+ T cells

Analytical biochemistry, 2023-06, Vol.670, p.115153-115153, Article 115153

2023

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Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.2729-2734

2017

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Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

The Journal of biological chemistry, 2015-12, Vol.290 (50), p.30078-30086

2015

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Intracellular nucleotide levels and the control of retroviral infections

Virology (New York, N.Y.), 2013-02, Vol.436 (2), p.247-254

2013

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Restriction of diverse retroviruses by SAMHD1

Retrovirology, 2013-03, Vol.10 (1), p.26-26, Article 26

2013

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HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis

Scientific reports, 2021-10, Vol.11 (1), p.20984-20984, Article 20984

2021

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The Strength Analysis and Structural Modification of VPX Chassis in Flight Environment

Journal of physics. Conference series, 2020-10, Vol.1624 (4), p.42047

2020

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Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1

Biochemical and biophysical research communications, 2019-06, Vol.513 (4), p.933-939

2019

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The C-terminal domain of feline and bovine SAMHD1 proteins has a crucial role in lentiviral restriction

The Journal of biological chemistry, 2020-03, Vol.295 (13), p.4252-4264

2020

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Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X

The Journal of biological chemistry, 2020-12, Vol.295 (50), p.16975-16986

2020

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Recent Advances in Lentiviral Vaccines for HIV-1 Infection

Frontiers in immunology, 2016-06, Vol.7, p.243-243

2016

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Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr

Frontiers in microbiology, 2016-10, Vol.7, p.1655-1655

2016

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Science & Technology
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Vpx
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Humans
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Virology
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Samhd1
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Viral Regulatory And Accessory Proteins - Genetics
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Hiv
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Cell Line
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Microbiology
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Vpr
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Human Immunodeficiency Virus
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Human Immunodeficiency Virus 2
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Hiv-2
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Hiv-2 - Genetics
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Sam Domain And Hd Domain-Containing Protein 1
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Virus Replication
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Hiv-1
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Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages

SAMHD1 … and Viral Ways around It

Interference with SAMHD1 Restores Late Gene Expression of Modified Vaccinia Virus Ankara in Human Dendritic Cells and Abrogates Type I Interferon Expression

Enhanced infection efficiency and cytotoxicity mediated by vpx-containing lentivirus in chimeric antigen receptor macrophage (CAR-M)

Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

Interaction Between Vpx and SAMHD1 , Vital for SAMHD1 Inhibition

Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection

Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells

HUSH, a Link Between Intrinsic Immunity and HIV Latency

Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy

Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites

Purified recombinant lentiviral Vpx proteins maintain their SAMHD1 degradation efficiency in resting CD4+ T cells

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

Intracellular nucleotide levels and the control of retroviral infections

Restriction of diverse retroviruses by SAMHD1

HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis

The Strength Analysis and Structural Modification of VPX Chassis in Flight Environment

Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1

The C-terminal domain of feline and bovine SAMHD1 proteins has a crucial role in lentiviral restriction

Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X

Recent Advances in Lentiviral Vaccines for HIV-1 Infection

Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr

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