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Allele-Specific p53 Mutant Reactivation

Cancer cell, 2012-05, Vol.21 (5), p.614-625

2012

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p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation

World journal of gastroenterology : WJG, 2015-01, Vol.21 (1), p.84-93

2015

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Small molecule induced reactivation of mutant p53 in cancer cells

Nucleic acids research, 2013-07, Vol.41 (12), p.6034-6044

2013

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The genetics of the p53 pathway, apoptosis and cancer therapy

Nature reviews. Drug discovery, 2008-12, Vol.7 (12), p.979-987

2008

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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Blood, 2019-04, Vol.133 (14), p.1572-1584

2019

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Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway

Toxicology and applied pharmacology, 2016-08, Vol.304, p.59-69

2016

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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Journal of the American Chemical Society, 2012-04, Vol.134 (15), p.6810-6818

2012

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Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network

Cell death and differentiation, 2013-08, Vol.20 (8), p.987-997

2013

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A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

Chemical Society reviews, 2020-10, Vol.49 (19), p.6995-714

2020

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Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

Nature communications, 2019-10, Vol.10 (1), p.4869-14, Article 4869

2019

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In vitro study of ochratoxin A in the expression of genes associated with neuron survival and viability

Toxicology (Amsterdam), 2023-01, Vol.483, p.153376, Article 153376

2023

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Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

British journal of cancer, 2019-03, Vol.120 (5), p.537-546

2019

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Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish

Toxicology letters, 2019-05, Vol.306, p.66-79

2019

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Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Annals of the rheumatic diseases, 2014-07, Vol.73 (7), p.1405-1413

2014

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BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways

International journal of molecular sciences, 2022-11, Vol.23 (22), p.14083

2022

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Alkylating DNA damage stimulates a regulated form of necrotic cell death

Genes & development, 2004-06, Vol.18 (11), p.1272-1282

2004

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Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function

Cancer research (Chicago, Ill.), 2017-02, Vol.77 (3), p.742-752

2017

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Storax Attenuates Cardiac Fibrosis following Acute Myocardial Infarction in Rats via Suppression of AT1R-Ankrd1-P53 Signaling Pathway

International journal of molecular sciences, 2022-10, Vol.23 (21), p.13161

2022

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FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma

Journal of hepatology, 2021-08, Vol.75 (2), p.351-362

2021

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Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells

Cell stress & chaperones, 2021-05, Vol.26 (3), p.473-493

2021

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Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1

Oncogene, 2007-05, Vol.26 (24), p.3473-3481

2007

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Current strategies to target p53 in cancer

Biochemical pharmacology, 2010-09, Vol.80 (5), p.724-730

2010

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Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium

Toxicology and applied pharmacology, 2010-10, Vol.248 (1), p.52-62

2010

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The p53 pathway in vasculature revisited: A therapeutic target for pathological vascular remodeling?

Pharmacological research, 2021-07, Vol.169, p.105683-105683, Article 105683

2021

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Aurora B Couples Chromosome Alignment with Anaphase by Targeting BubR1, Mad2, and Cenp-E to Kinetochores

The Journal of cell biology, 2003-04, Vol.161 (2), p.267-280

2003

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Allele-Specific p53 Mutant Reactivation

p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation

Small molecule induced reactivation of mutant p53 in cancer cells

The genetics of the p53 pathway, apoptosis and cancer therapy

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

In vitro study of ochratoxin A in the expression of genes associated with neuron survival and viability

Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways

Alkylating DNA damage stimulates a regulated form of necrotic cell death

Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function

Storax Attenuates Cardiac Fibrosis following Acute Myocardial Infarction in Rats via Suppression of AT1R-Ankrd1-P53 Signaling Pathway

FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1

Current strategies to target p53 in cancer

Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium

The p53 pathway in vasculature revisited: A therapeutic target for pathological vascular remodeling?

Aurora B Couples Chromosome Alignment with Anaphase by Targeting BubR1, Mad2, and Cenp-E to Kinetochores

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