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Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

Molecules (Basel, Switzerland), 2019-02, Vol.24 (4), p.796

2019

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Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity

Journal of medicinal chemistry, 2024-07, Vol.67 (14), p.12410-12427

2024

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Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling

Angewandte Chemie International Edition, 2013-12, Vol.52 (49), p.12892-12896

International ed. in English, 2013

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Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13327-13355

2021

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Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice

Science translational medicine, 2016-09, Vol.8 (357), p.357ra122

2016

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Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of Hyoscyamus muticus L. and their antimicrobial activity

Scientific reports, 2023-06, Vol.13 (1), p.10397-10397, Article 10397

2023

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Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice

Hepatology (Baltimore, Md.), 2016-02, Vol.63 (2), p.512-523

2016

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Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV‑1 Activities and Improved Oral Bioavailability

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16526-16540

2022

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Tropane alkaloids GC/MS analysis and low dose elicitors’ effects on hyoscyamine biosynthetic pathway in hairy roots of Algerian Datura species

Scientific reports, 2018-12, Vol.8 (1), p.17951-8, Article 17951

2018

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Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus

Journal of natural products (Washington, D.C.), 2021-08, Vol.84 (8), p.2272-2281

2021

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The patent review of the biological activity of tropane containing compounds

Expert opinion on therapeutic patents, 2023-12, Vol.33 (12), p.875-899

2023

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Alteration in the callogenesis, tropane alkaloid formation, and gene expression in Hyoscyamus niger under clinorotation

Protoplasma, 2024-03, Vol.261 (2), p.293-302

2024

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Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.740-751

2009

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Deuterated [18F]fluoroethyl tropane analogs as dopamine transporter probes: Synthesis and biological evaluation

Nuclear medicine and biology, 2023-03, Vol.118-119, p.108334-108334, Article 108334

2023

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Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

International journal of molecular sciences, 2020-11, Vol.21 (23), p.9050

2020

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European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

European journal of nuclear medicine and molecular imaging, 2013-01, Vol.40 (2), p.213-227

2013

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Cytotoxic Activity of Tropane Alkaloides of Species of Erythroxylum

Mini reviews in medicinal chemistry, 2021-01, Vol.21 (17), p.2458-2480

2021

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Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families

Biological chemistry, 2017-02, Vol.398 (2), p.237-249

2017

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Searching for the synergistic effect between aclidinium and formoterol: From bench to bedside

Respiratory medicine, 2015-10, Vol.109 (10), p.1305-1311

2015

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The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults

Experimental eye research, 2014-11, Vol.128, p.181-189

2014

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Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: In vitro plasma inactivation and pharmacological activity of its main metabolites

European journal of pharmaceutical sciences, 2010-03, Vol.39 (5), p.283-290

2010

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High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice

Biochemical pharmacology, 2015-10, Vol.97 (4), p.531-541

2015

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A functional selective effect of oxytocin secreted under restraint stress in rats

European journal of pharmacology, 2021-08, Vol.904, p.174182-174182, Article 174182

2021

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The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide

Pulmonary pharmacology & therapeutics, 2014-08, Vol.28 (2), p.114-121

2014

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Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity

Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice

Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of Hyoscyamus muticus L. and their antimicrobial activity

Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice

Tropane Alkaloid Isolated from Erythroxylum bezerrae Exhibits Neuropharmacological Potential in an Adult Zebrafish (Danio rerio) Model

Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV‑1 Activities and Improved Oral Bioavailability

Tropane alkaloids GC/MS analysis and low dose elicitors’ effects on hyoscyamine biosynthetic pathway in hairy roots of Algerian Datura species

Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus

The patent review of the biological activity of tropane containing compounds

Alteration in the callogenesis, tropane alkaloid formation, and gene expression in Hyoscyamus niger under clinorotation

Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile

Deuterated [18F]fluoroethyl tropane analogs as dopamine transporter probes: Synthesis and biological evaluation

Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

Cytotoxic Activity of Tropane Alkaloides of Species of Erythroxylum

Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families

Searching for the synergistic effect between aclidinium and formoterol: From bench to bedside

The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults

Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: In vitro plasma inactivation and pharmacological activity of its main metabolites

High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice

A functional selective effect of oxytocin secreted under restraint stress in rats

The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide

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